Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

1992 • 4,765 citations

NAD(P)H Oxidase

2000 • 2,902 citations

Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease

2000 • 2,616 citations

Endothelial Function and Dysfunction

2007 • 2,487 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction

2000 • 2,076 citations

Close relation of endothelial function in the human coronary and peripheral circulations

1995 • 2,061 citations

Circulating Endothelial Progenitor Cells and Cardiovascular Outcomes

2005 • 2,023 citations

Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease

2001 • 1,944 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Endothelial Nitric Oxide Synthase in Vascular Disease

2006 • 1,777 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,435 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,341 citations

Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

2001 • 1,192 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

2001 • 1,108 citations

Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events

2005 • 1,073 citations

Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients

2001 • 1,061 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

2001 • 994 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia

2004 • 937 citations

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

2003 • 930 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

2002 • 838 citations

Risk Stratification for Postoperative Cardiovascular Events via Noninvasive Assessment of Endothelial Function

2002 • 786 citations

Predictive value of noninvasivelydetermined endothelial dysfunction for long-term cardiovascular events inpatients with peripheral vascular disease

2003 • 764 citations

Does superoxide underlie the pathogenesis of hypertension?

1991 • 760 citations

Endothelial Regulation of Vasomotion in ApoE-Deficient Mice

2001 • 719 citations

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

1999 • 689 citations

Superoxide and peroxynitrite inatherosclerosis.

1994 • 674 citations

Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

2003 • 665 citations

Expression of Angiotensin II and Interleukin 6 in Human Coronary Atherosclerotic Plaques

2000 • 649 citations

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

2002 • 606 citations

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1996 • 593 citations

Does ADMA Cause Endothelial Dysfunction?

2000 • 590 citations

Vascular Superoxide Production by NAD(P)H Oxidase

2000 • 565 citations

Antioxidant Vitamin C Improves Endothelial Dysfunction in Chronic Smokers

1996 • 563 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

Determination of age-related increases in large artery stiffness by digital pulse contour analysis

2002 • 554 citations

Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis.

1991 • 531 citations

Circulating Microparticles From Patients With Myocardial Infarction Cause Endothelial Dysfunction

2001 • 491 citations

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

2002 • 480 citations

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion

1995 • 479 citations

Allopurinol Normalizes Endothelial Dysfunction in Type 2 Diabetics With Mild Hypertension

2000 • 475 citations

Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

1999 • 474 citations

Perspectives on systolic hypertension. The Framingham study.

1980 • 467 citations

Effect of Antioxidant Vitamins on the Transient Impairment of Endothelium—Dependent Brachial Artery Vasoactivity Following a Single High-Fat Meal

1997 • 465 citations

Increased Accumulation of Tissue ACE in Human Atherosclerotic Coronary Artery Disease

1996 • 431 citations

ADMA and oxidative stress

2003 • 420 citations

Statin-Sensitive Dysregulated AT1 Receptor Function and Density in Hypercholesterolemic Men

1999 • 401 citations

Circulating endothelial cells

2005 • 381 citations

Prostacyclin is a circulating hormone

1978 • 380 citations

Asymmetric Dimethylarginine and the Risk of Cardiovascular Events and Death in Patients With Coronary Artery Disease

2005 • 379 citations

Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.

1996 • 375 citations

Circulating Microparticles

2006 • 360 citations

Endothelin in Coronary Endothelial Dysfunction and Early Atherosclerosis in Humans

1995 • 358 citations

Integrins and Angiogenesis

2004 • 290 citations

Early Morning Attenuation of Endothelial Function in Healthy Humans

2004 • 268 citations

Vasodilator-Stimulated Phosphoprotein Serine 239 Phosphorylation as a Sensitive Monitor of Defective Nitric Oxide/cGMP Signaling and Endothelial Dysfunction

2000 • 255 citations

Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity

2004 • 250 citations

Xanthine Oxidase Inhibition With Oxypurinol Improves Endothelial Vasodilator Function in Hypercholesterolemic but Not in Hypertensive Patients

1997 • 247 citations

Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase

1996 • 234 citations

Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells

1997 • 226 citations

Effect of Native and Oxidized Low-Density Lipoprotein on Endothelial Nitric Oxide and Superoxide Production

2000 • 222 citations

Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells

1986 • 197 citations

Assessment of endothelial function using peripheral waveform analysis

2002 • 172 citations

Endothelial dysfunction in peripheral arterial disease is related to increase in plasma markers of inflammation and severity of peripheral circulatory impairment but not to classic risk factors and atherosclerotic burden

2003 • 165 citations

Oxidative Stress Increases Endothelin-1 Synthesis in Human Coronary Artery Smooth Muscle Cells

2001 • 158 citations

Use of the ICF in identifying factors that impact participation in physical activity/rehabilitation among people with disabilities

2006 • 156 citations

Systemic Endothelial Dysfunction as an Early Predictor of Adverse Outcome in Heart Failure

2005 • 155 citations

Oxidative Stress Increases Synthesis of Big Endothelin-1 by Activation of the Endothelin-1 Promoter

2000 • 154 citations

Brachial Artery Flow-Mediated Dilation and Asymmetrical Dimethylarginine in the Cardiovascular Risk in Young Finns Study

2007 • 137 citations

Statin decreases endothelial microparticle release from human coronary artery endothelial cells: implication for the Rho-kinase pathway

2004 • 126 citations

Assembly and regulation of NADPH oxidase and nitric oxide synthase

1994 • 123 citations

Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension

2001 • 123 citations

Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans

1997 • 106 citations

Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function

2006 • 85 citations

Drug-induced vascular injury—a quest for biomarkers

2004 • 81 citations

Cross-sectional evaluation of brachial artery flow-mediated vasodilation and C-reactive protein in healthy individuals

2004 • 71 citations

Upregulation of Vascular NAD(P)H Oxidase Subunit gp91phox and Impairment of the Nitric Oxide Signal Transduction Pathway in Hypertension

2001 • 69 citations

Determinants of short-term variation in arterial flow-mediated dilatation in healthy young men

2006 • 45 citations

NITRIC OXIDE‐DEPENDENT ENDOTHELIAL FUNCTION IS UNAFFECTED BY ALLOPURINOL IN HYPERCHOLESTEROLAEMIC SUBJECTS

1999 • 39 citations

Clinical trials update from the Heart Failure Society of America meeting: FIX‐CHF‐4, selective cardiac myosin activator and OPT‐CHF

2006 • 37 citations

AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery disease

2006 • 29 citations

Regulation of NO Synthesis in Endothelial Cells

1998 • 18 citations

Regarding “Endothelium-dependent vasodilation is impaired in both microcirculation and macrocirculation during acute hyperglycemia”

1999 • 4 citations