Cellular and molecular actions of binary toxins possessing ADP-ribosyltransferase activity

Atomic structure of the actin: DNase I complex

1990 • 1,897 citations

Atomic model of the actin filament

1990 • 1,657 citations

Electron microscope studies on the structure of natural and synthetic protein filaments from striated muscle

1963 • 1,452 citations

Actin polymerization and its regulation by proteins from nonmuscle cells.

1982 • 739 citations

At least six different actins are expressed in a higher mammal: An analysis based on the amino acid sequence of the amino-terminal tryptic peptide

1978 • 738 citations

Nonmuscle Actin-Binding Proteins

1985 • 589 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

Botulinum C2 toxin ADP-ribosylates actin

1986 • 503 citations

Actin Polymerization and ATP Hydrolysis

1987 • 439 citations

Botulinum Neurotoxin and Tetanus Toxin

1989 • 393 citations

Clostridium botulinum toxins

1982 • 361 citations

Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain

1988 • 324 citations

Actin: protein structure and filament dynamics.

1991 • 309 citations

Kinetic studies on the interaction between botulinum toxin type A and the cholinergic neuromuscular junction.

1980 • 302 citations

Botulism. The Organism, Its Toxins, The Disease.

1978 • 270 citations

Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis.

1986 • 247 citations

Clostridium botulinum type C produces a novel ADP‐ribosyltransferase distinct from botulinum C2 toxin

1987 • 238 citations

Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. I. Ultrastructural autoradiographic localization and quantitation of distinct membrane acceptors for types A and B on motor nerves.

1986 • 233 citations

Purification and characterization of two components of botulinum C2 toxin

1980 • 210 citations

Mechanism of action of phalloidin on the polymerization of muscle actin

1981 • 207 citations

Intracellularly injected tetanus toxin inhibits exocytosis in bovine adrenal chromaffin cells

1986 • 183 citations

Clostridium perfringens iota toxin ADP‐ribosylates skeletal muscle actin in Arg‐177

1987 • 180 citations

Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product.

1988 • 178 citations

ADP-ribosylated actin caps the barbed ends of actin filaments.

1988 • 174 citations

Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.

1988 • 161 citations

Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin

1988 • 153 citations

Binding of phosphate to F-ADP-actin and role of F-ADP-Pi-actin in ATP-actin polymerization.

1988 • 142 citations

Purification and characterization of Clostridium perfringens iota toxin: dependence on two nonlinked proteins for biological activity

1986 • 139 citations

Purification of the 22 kDa protein substrate of botulinum ADP‐ribosyltransferase C3 from porcine brain cytosol and its characterization as a GTP‐binding protein highly homologous to the rho gene product

1989 • 139 citations

Isolated Light Chains of Botulinum Neurotoxins Inhibit Exocytosis

1989 • 132 citations

ADP-ribosylation of the bovine brain rho protein by botulinum toxin type C1.

1988 • 126 citations

ADP‐ribosylation of skeletal muscle and non‐muscle actin by Clostridium perfringens iota toxin

1988 • 125 citations

Botulinum C2 toxin ADP-ribosylates actin and disorganizes the microfilament network in intact cells.

1987 • 109 citations

ADP-ribosylation of a Mr 21,000 membrane protein by type D botulinum toxin.

1987 • 104 citations

Role of the heavy and light chains of botulinum neurotoxin in neuromuscular paralysis.

1987 • 103 citations

Molecular basis for the pathological actions of Clostridium perfringens iota toxin

1987 • 101 citations

Ammonium chloride and methylamine hydrochloride antagonize clostridial neurotoxins.

1983 • 95 citations

Activation of botulinum C2 toxin by trypsin

1987 • 92 citations

Secretory Vesicle-Associated Proteins and Their Role in Exocytosis

1990 • 90 citations

Response of mouse intestinal loop to botulinum C2 toxin: enterotoxic activity induced by cooperation of nonlinked protein components

1983 • 90 citations

Interaction of fragments B and C of tetanus toxin with neural and thyroid membranes and with gangliosides.

1980 • 89 citations

Actin Involvement in Exocytosis from PC12 Cells: Studies on the Influence of Botulinum C2 Toxin on Stimulated Noradrenaline Release

1989 • 86 citations

Purification and properties of the cytosolic substrate for botulinum ADP-ribosyltransferase. Identification as an Mr 22,000 guanine nucleotide-binding protein.

1988 • 84 citations

Clostridium perfringens iota toxin: Synergism between two proteins

1986 • 79 citations

Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils.

1988 • 77 citations

The amino acid sequence of actin from chicken skeletal muscle actin and chicken gizzard smooth muscle actin

1979 • 74 citations

ADP‐ribosylation of platelet actin by botulinum C2 toxin

1986 • 73 citations

Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.

1988 • 72 citations

The interaction between aminoquinolines and presynaptically acting neurotoxins.

1982 • 71 citations

ADP-ribosylation of nonmuscle actin with component I of C2 toxin

1986 • 71 citations

Purification of the Clostridium spiroforme binary toxin and activity of the toxin on HEp-2 cells

1989 • 71 citations

Molecular basis for the pharmacological actions of Clostridium botulinum type C2 toxin.

1984 • 69 citations

Production by Clostridium spiroforme of an iotalike toxin that possesses mono(ADP-ribosyl)transferase activity: identification of a novel class of ADP-ribosyltransferases

1989 • 67 citations

The binary toxin produced by Clostridium botulinum enters cells by receptor-mediated endocytosis to exert its pharmacologic effects.

1989 • 63 citations

A comparison of the pharmacological properties of Clostridium botulinum type C1 and C2 toxins.

1982 • 62 citations

Activation of a Toxic Component of Clostridium botulinum Types C and D by Trypsin

1972 • 62 citations

Lethal and vascular permeability activities of botulinum C2 toxin induced by separate injections of the two toxin components

1983 • 61 citations

Isolated Light Chain of Tetanus Toxin Inhibits Exocytosis: Studies in Digitonin‐Permeabilized Cells

1989 • 61 citations

Botulinum ADP‐ribosyltransferase C3 but not botulinum neurotoxins C1 and D ADP‐ribosylates low molecular mass GTP‐binding proteins

1987 • 57 citations

ADP‐ribosylation of actin causes increase in the rate of ATP exchange and inhibition of ATP hydrolysis

1989 • 56 citations

Vascular permeability activity of botulinum C2 toxin elicited by cooperation of two dissimilar protein components

1981 • 55 citations

Characterization of fragment C and tetanus toxin binding to rat brain membranes.

1981 • 55 citations

Evidence that botulinum C2 toxin has two dissimilar components

1980 • 51 citations

DNA sequence of exoenzyme C3, an ADP-ribosyltransferase encoded byClostridium botulinumC and D phages

1990 • 48 citations

Speculation and C₂ Toxin Production by Clostridium botulinum Type C Strains Producing No C₁ Toxin

1978 • 47 citations

Cation binding sites on actin: A structural relationship between antigenic epitopes and cation exchange

1988 • 44 citations

Steady state length distribution of F-actin under controlled fragmentation and mechanism of length redistribution following fragmentation.

1984 • 43 citations

Binding of the two components of C2 toxin to epithelial cells and brush borders of mouse intestine

1985 • 41 citations

ADP-Ribosylating Microbial Toxins

1984 • 41 citations

Identification of rho as a substrate for botulinum toxin C₃‐catalyzed ADP‐ribosylation

1989 • 41 citations

The binding fragment from tetanus toxin antagonizes the neuromuscular blocking actions of botulinum toxin.

1984 • 41 citations

Purification and characterization from bovine brain membranes of a GTP-binding protein with a Mr of 21,000, ADP-ribosylated by an ADP-ribosyltransferase contaminated in botulinum toxin type C1 4- Identification as the rhoA gene product

1990 • 37 citations

Inhibition of the contraction of the isolated longitudinal muscle of the guinea-pig ileum by botulinum C2 toxin: Evidence for a role of G/F-actin transition in smooth muscle contraction

1989 • 36 citations

Bacteriophages and Plasmids in Clostridium botulinum and Clostridium tetani and Their Relationship to Production of Toxins

1989 • 35 citations

Activation of a Toxic Component of Clostridium botulinum Types C and D by Trypsin

1972 • 32 citations

Inhibition of Histamine Release from Rat Mast Cells by Botulinum C2 Toxin

1987 • 22 citations

cDNA cloning of Gb, the substrate for botulinum ADP-ribosyltransferase from bovine adrenal gland and its identification as a rho gene product

1989 • 21 citations

Actions of the Clostridium botulinum binary toxin on the structure and function of Y-1 adrenal cells.

1988 • 20 citations

Botulinum toxin D ADP-ribosylates A 22–24 KDa membrane protein in platelets and HL-60 cells that is distinct from p21N-RAS

1988 • 19 citations

Response of tissue-cultured cynomolgus monkey kidney cells to botulinum C2 toxin

1987 • 18 citations

Heterogeneities of Two Components of C2 Toxin Produced by Clostridium botulinum Types C and D

1986 • 17 citations

ADP-ribosylation of 24–26-kDa GTP-binding Proteins Localized in Neuronal and Non-neuronal Cells by Botulinum Neurotoxin D

1989 • 17 citations

Immunochemical Identification of the ADP-Ribosyltransferase in Botulinum C1 Neurotoxin as C3 Exoenzyme—Like Molecule1

1990 • 17 citations

THE SUSCEPTIBILITY OF THE MALLARD DUCK (ANAS PLATYRHYNCHOS) TO CLOSTRIDIUM BOTULINUM C2 TOXIN

1980 • 16 citations

Molecular Structure and Biological Activities of Clostridium Botulinum C2 Toxin

1990 • 15 citations

Separation of toxic activity and ADP-ribosylation activity of botulinum neurotoxin D.

1990 • 14 citations

C2 toxicity in extract of Clostridium botulinum type C spores

1983 • 10 citations

A 22 kDa ras‐related G‐protein is the substrate for an ADP‐ribosyltransferase from Clostridium botulinum

1988 • 10 citations

Axoplasmic Transport and Transynaptic Movement of Tetanus Toxin

1989 • 9 citations

Amino-acid composition of components I and II of botulinum C₂toxin

1987 • 1 citations