Purification and characterization from bovine brain membranes of a GTP-binding protein with a Mr of 21,000, ADP-ribosylated by an ADP-ribosyltransferase contaminated in botulinum toxin type C1 4- Identification as the rhoA gene product

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

ras GENES

1987 • 3,818 citations

[1] Measurement of molecular weights by electrophoresis on SDS-acrylamide gel

1972 • 1,733 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.

1986 • 533 citations

A novel ras-related gene family

1985 • 487 citations

Molecular Pharmacology of Botulinum Toxin and Tetanus Toxin

1986 • 469 citations

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library.

1987 • 403 citations

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

1988 • 334 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

The ral gene: a new ras related gene isolated by the use of a synthetic probe.

1986 • 264 citations

Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.

1987 • 259 citations

Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins

1989 • 258 citations

Purification of ras GTPase activating protein from bovine brain.

1988 • 255 citations

Clostridium botulinum type C produces a novel ADP‐ribosyltransferase distinct from botulinum C2 toxin

1987 • 238 citations

Nucleotide and deduced amino acid sequences of a GTP-binding protein family with molecular weights of 25,000 from bovine brain.

1988 • 234 citations

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

1987 • 216 citations

Purification and characterization of a novel GTP-binding protein with a molecular weight of 24,000 from bovine brain membranes.

1988 • 207 citations

Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins.

1988 • 204 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization.

1988 • 185 citations

Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product.

1988 • 178 citations

Nucleotide sequence of human rho cDNA clone 12

1987 • 143 citations

The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene.

1987 • 142 citations

Purification of the 22 kDa protein substrate of botulinum ADP‐ribosyltransferase C3 from porcine brain cytosol and its characterization as a GTP‐binding protein highly homologous to the rho gene product

1989 • 139 citations

Coding sequence of humanrhocDNAs clone 6 and clone 9

1988 • 137 citations

ADP-ribosylation of the bovine brain rho protein by botulinum toxin type C1.

1988 • 126 citations

ADP-ribosylation of a Mr 21,000 membrane protein by type D botulinum toxin.

1987 • 104 citations

Guanine nucleotide-binding proteins that enhance choleragen ADP-ribosyltransferase activity: nucleotide and deduced amino acid sequence of an ADP-ribosylation factor cDNA.

1988 • 99 citations

Purification and characterization of a GTP-binding protein with a molecular weight of 20,000 in bovine brain membranes. Identification as the rho gene product.

1988 • 93 citations

ADP-ribosylation of a 21-24 kDa eukaryotic protein(s) by C3, a novel botulinum ADP-ribosyltransferase, is regulated by guanine nucleotide

1987 • 89 citations

Purification and properties of the cytosolic substrate for botulinum ADP-ribosyltransferase. Identification as an Mr 22,000 guanine nucleotide-binding protein.

1988 • 84 citations

Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go

1987 • 69 citations

Complete coding sequences of therasrelatedrab3 and 4 cDNAs

1988 • 65 citations

Botulinum ADP‐ribosyltransferase C3 but not botulinum neurotoxins C1 and D ADP‐ribosylates low molecular mass GTP‐binding proteins

1987 • 57 citations

Botulinum toxin‐induced ADP‐ribosylation and inhibition of exocytosis are unrelated events

1988 • 45 citations

Intrasynaptosomal distribution of the ras, rho and smg-25A GTP-binding proteins in bovine brain

1989 • 42 citations

Purification and characterization of c-Ki-ras p21 from bovine brain crude membranes.

1988 • 42 citations

ADP-ribosylation by type C1 and D botulinum neurotoxins: Stimulation by guanine nucleotides and inhibition by guanidino-containing compounds

1987 • 41 citations