Mutations in the Cytoplasmic Domain of the Integrin β1 Chain Indicate a Role for Endocytosis Factors in Bacterial Internalization

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY

1963 • 24,942 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

1993 • 2,182 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation.

1989 • 920 citations

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1986 • 854 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells

1990 • 802 citations

Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells

1987 • 599 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

1983 • 558 citations

A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12

1985 • 535 citations

Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information

1992 • 532 citations

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

1990 • 508 citations

Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.

1983 • 495 citations

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

1993 • 447 citations

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts

1983 • 445 citations

Inside-out integrin signalling

1992 • 439 citations

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

1987 • 355 citations

Acidification of the cytosol inhibits endocytosis from coated pits.

1987 • 345 citations

Modulation of the Affinity of Integrin α _IIb β ₃ (GPIIb-IIIa) by the Cytoplasmic Domain of α _IIb

1991 • 322 citations

Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin.

1985 • 309 citations

Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains

1992 • 307 citations

Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants.

1992 • 297 citations

Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association

1992 • 285 citations

Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication

1988 • 278 citations

Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain.

1993 • 267 citations

Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts.

1989 • 256 citations

The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation

1991 • 246 citations

Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells.

1990 • 238 citations

Endocytosis and recycling of the fibronectin receptor in CHO cells.

1989 • 231 citations

Initial events during phagocytosis by macrophages viewed from outside and inside the cell: membrane-particle interactions and clathrin.

1982 • 217 citations

Alterations in the protein composition of maturing phagosomes.

1992 • 205 citations

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages.

1993 • 201 citations

The removal of extracellular fibronectin from areas of cell-substrate contact

1981 • 191 citations

Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells

1992 • 188 citations

Expression of normal and mutant avian integrin subunits in rodent cells [published erratum appears in J Cell Biol 1989 Oct;109(4 Pt 1):1187]

1989 • 181 citations

Focal adhesion sites and the removal of substratum-bound fibronectin.

1986 • 176 citations

Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density.

1993 • 165 citations

The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a β turn

1991 • 165 citations

The invasin protein of Yersinia enterocolitica: internalization of invasin-bearing bacteria by eukaryotic cells is associated with reorganization of the cytoskeleton.

1992 • 154 citations

Protein tyrosine phosphorylation and the adhesive functions of platelets

1991 • 148 citations

Syringe loading introduces macromolecules into living mammalian cell cytosol

1992 • 121 citations

Two forms of the low-affinity Fc receptor for IgE differentially mediate endocytosis and phagocytosis: identification of the critical cytoplasmic domains.

1992 • 119 citations

Clathrin structure characterized with monoclonal antibodies. I. Analysis of multiple antigenic sites.

1985 • 117 citations

100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis.

1989 • 110 citations

The cytoplasmic tail of lysosomal acid phosphatase contains overlapping but distinct signals for basolateral sorting and rapid internalization in polarized MDCK cells.

1993 • 108 citations

Hyperosmolarity inhibits galactosyl receptor-mediated but not fluid phase endocytosis in isolated rat hepatocytes

1989 • 94 citations

Adaptins

1992 • 89 citations

Cytosol- and clathrin-dependent stimulation of endocytosis in vitro by purified adaptors.

1992 • 84 citations

Microelisa reader quantitation of fixed, stained, solubilized cells in microtitre dishes.

1988 • 76 citations

Activation of Phagocytic Cells' C3 Receptors for Phagocytosis

1985 • 73 citations

Kinetic and morphological evidence for endocytosis of mammalian cell integrin receptors by using an anti-fibronectin receptor β subunit monoclonal antibody

1989 • 54 citations

Signal transduction mechanisms through Fcγ receptors on the mouse macrophage surface

1991 • 34 citations

Internalization of the α5β1 Integrin Does Not Depend on "NPXY" Signals

1994 • 26 citations

Cellular Internalization of Staphylococcus aureus Coated with Protein A-Bound Anti-integrin Antibodies

1993 • 2 citations