Loss of DNA mismatch repair facilitates reactivation of a reporter plasmid damaged by cisplatin

Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines.

1989 • 614 citations

The role of DNA mismatch repair in platinum drug resistance.

1996 • 607 citations

Cellular accumulation of the anticancer agent cisplatin: A review

1993 • 557 citations

Cisplatin and DNA repair in cancer chemotherapy

1995 • 506 citations

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

1994 • 506 citations

Loss of DNA mismatch repair in acquired resistance to cisplatin.

1996 • 505 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

1996 • 422 citations

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

1995 • 362 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.

1994 • 343 citations

Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II)

1988 • 314 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

Mismatch repair: mechanisms and relationship to cancer susceptibility

1995 • 307 citations

Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines.

1995 • 301 citations

Cisplatin and Adriamycin Resistance Are Associated with MutLα and Mismatch Repair Deficiency in an Ovarian Tumor Cell Line

1996 • 297 citations

Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.

1991 • 288 citations

In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair.

1997 • 275 citations

The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin

1996 • 198 citations

Recognition and Repair of Compound DNA Lesions (Base Damage and Mismatch) by Human Mismatch Repair and Excision Repair Systems

1997 • 198 citations

Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6.

1997 • 193 citations

Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells.

1997 • 179 citations

Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand cross-links in Chinese hamster ovary cells.

1991 • 157 citations

Formation and repair of cisplatin-induced adducts to DNA in cultured normal and repair-deficient human fibroblasts.

1988 • 152 citations

Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.

1996 • 148 citations

Rapid Emergence of Acquired cis-Diamminedichloroplatinum(II) Resistance in an In Vivo Model of Human Ovarian Carcinoma

1990 • 134 citations

DNA repair in cells sensitive and resistant to cis-diamminedichloroplatinum(II): host-cell reactivation of damaged plasmid DNA

1989 • 106 citations

DNA Adducts of cis-Diamminedichloroplatinum(II) and Its Trans Isomer Inhibit RNA Polymerase II Differentially in Vivo

1995 • 101 citations

Repair of individual DNA strands in the hamster dihydrofolate reductase gene after treatment with ultraviolet light, alkylating agents, and cisplatin.

1993 • 66 citations

Enhanced repair of a cisplatin‐damaged reporter chloramphenicol‐O‐acetyltransferase gene and altered activities of DNA polymerases α and β, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy

1994 • 55 citations

The role of DNA repair in resistance of L1210 cells to isomeric 1,2-diaminocyclohexaneplatinum complexes and ultraviolet irradiation

1991 • 27 citations