Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats

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1997 • 38,984 citations

Tissue inhibitors of metalloproteinases: evolution, structure and function

2000 • 1,873 citations

Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C

2002 • 1,150 citations

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

1998 • 1,032 citations

Matrix Metalloproteinase-2 Is an Interstitial Collagenase

1995 • 917 citations

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides 1 1Edited by I. A. Wilson

2000 • 722 citations

Extracellular Matrix Degradation and the Role of Hepatic Stellate Cells

2001 • 486 citations

Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis

2000 • 463 citations

Activation of hepatic stellate cells - a key issue in liver fibrosis

2002 • 417 citations

Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition

2002 • 415 citations

Genetic polymorphisms and the progression of liver fibrosis: A critical appraisal

2003 • 350 citations

Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

1996 • 349 citations

Hepatic Stellate Cell Behavior during Resolution of Liver Injury

2001 • 334 citations

Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis

1996 • 321 citations

Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-α and TGF-β1

1999 • 317 citations

Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis

1996 • 289 citations

Monitoring of collagen and collagen fragments in chromatography of protein mixtures

1980 • 261 citations

The role of Smad3 in mediating mouse hepatic stellate cell activation

2001 • 253 citations

Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model

2000 • 248 citations

Inhibition of transforming growth factorβ prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats

2000 • 243 citations

Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat

2003 • 242 citations

Signal transduction in hepatic stellate cells

1998 • 241 citations

Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse

2002 • 215 citations

Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat

2000 • 208 citations

Mutation in collagen‐I that confers resistance to the action of collagenase results in failure of recovery from CCl₄‐induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration

2002 • 208 citations

Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.

1992 • 207 citations

Posttranscriptional Regulation of Collagen α1(I) mRNA in Hepatic Stellate Cells

1997 • 205 citations

New aspects of hepatic fibrosis

2000 • 199 citations

Tissue inhibitors of metalloproteinases and programmed cell death: conundrums, controversies and potential implications.

2001 • 187 citations

Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice

2003 • 186 citations

Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats

1995 • 167 citations

Attenuation of CCl₄-induced hepatic fibrosis by GdCl₃treatment or dietary glycine

2001 • 157 citations

Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient l-amino acid-defined diet

2004 • 153 citations

Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver

2003 • 138 citations

Angiotensin-I-Converting Enzyme Inhibitors May Be an Alternative Anti-Angiogenic Strategy in the Treatment of Liver Fibrosis and Hepatocellular Carcinoma

2002 • 121 citations

Human Combinatorial Fab Library Yielding Specific and Functional Antibodies against the Human Fibroblast Growth Factor Receptor 3

2003 • 118 citations

Cell cycle-associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts

1998 • 98 citations

Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells

2001 • 83 citations

Adenosine reverses a preestablished CCl4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats

2001 • 82 citations

Inhibition of rat liver fibrogenesis through noradrenergic antagonism

2002 • 80 citations

Adenosine Partially Prevents Cirrhosis Induced by Carbon Tetrachloride in Rats

1990 • 76 citations

Disruption of the Tissue Inhibitor of Metalloproteinase-1 Gene Results in Altered Reproductive Cyclicity and Uterine Morphology in Reproductive-Age Female Mice1

2000 • 72 citations

Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat

2001 • 59 citations

Secretion of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases into the intrauterine compartments during early pregnancy

1999 • 52 citations

Herbal medicine Sho-saiko-to (TJ-9) increases expression matrix metalloproteinases (MMPs) with reduced expression of tissue inhibitor of metalloproteinases (TIMPs) in rat stellate cell

2004 • 39 citations

Inhibition of apoptosis in rat mesangial cells by tissue inhibitor of metalloproteinase-1

2002 • 31 citations

Hepatocyte growth factor promotes liver regeneration and protein synthesis after hepatectomy in cirrhotic rats.

2001 • 26 citations

Inhibition on the production of collagen type I, III of activated hepatic stellate cells by antisense TIMP-1 recombinant plasmid

2003 • 22 citations

Fat-storing cells and myofibroblasts are involved in the initial phase of carbon tetrachloride-induced hepatic fibrosis in BN/BiRij rats.

1994 • 17 citations

Phenobarbital in Comparison with Carbon Tetrachloride and Phenobarbital-Induced Cirrhosis in Rat Liver Regeneration

1999 • 15 citations