Role of alpha‐fetoprotein in the diagnosis and management of hepatocellular carcinoma

Illegitimate transcription: transcription of any gene in any cell type.

1989 • 647 citations

Demonstration of a New Protein Fraction in Serum from the Human Fetus

1956 • 468 citations

Early Recognition of Hepatocellular Carcinoma Based on Altered Profiles of Alpha-Fetoprotein

1994 • 354 citations

Selective internal radiation therapy for nonresectable hepatocellular carcinoma with intraarterial infusion of 90yttrium microspheres

1998 • 345 citations

Sites of Serum α-Fetoprotein Synthesis in the Human and in the Rat*

1967 • 291 citations

A collaborative study for the evaluation of lectin-reactive alpha-fetoproteins in early detection of hepatocellular carcinoma.

1993 • 285 citations

Serum alpha-fetoprotein in patients with neoplasms of the gastrointestinal tract.

1975 • 255 citations

A clinical study of lectin-reactive alpha-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patients

1995 • 176 citations

In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.

1997 • 170 citations

Detection of α-fetoprotein mRNA, an indicator of hematogenous spreading hepatocellular carcinoma, in the circulation: A possible predictor of metastatic hepatocellular carcinoma

1994 • 135 citations

Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood

1995 • 133 citations

Structure of the asparagine-linked sugar chains of alpha-fetoprotein purified from human ascites fluid.

1980 • 113 citations

Serum Alpha-Fetoprotein Estimations and Doubling Time in Hepatocellular Carcinoma: Influence of Therapy and Possible Value in Early Detection

1980 • 91 citations

Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase

1995 • 91 citations

Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene.

1995 • 75 citations

Sugar chains of human cord serum alpha-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas.

1993 • 65 citations

RADIOIMMUNOASSAY OF ALPHA-FETOPROTEIN IN HUMAN PLASMA

1973 • 65 citations

Semiquantification of circulating hepatocellular carcinoma cells by reverse transcriptase polymerase chain reaction

1997 • 64 citations

Establishment of assay kits for the determination of microheterogeneities of alpha-fetoprotein using lectin-affinity electrophoresis

1993 • 64 citations

Alpha-fetoprotein concentrations measured by radioimmunoassay in diagnosing and excluding hepatocellular carcinoma.

1978 • 62 citations

'Hepatoma-specific' alphafetoprotein may permit preclinical diagnosis of malignant change in patients with chronic liver disease

1997 • 53 citations

Sensitive Assay for Detection of Hepatocellular Carcinoma Associated Gene Transcription (α-Fetoprotein mRNA) in Blood

1995 • 48 citations

Human .alpha.-fetoprotein primary structure: a mass spectrometric study

1991 • 43 citations

Detection of hepatocellular carcinoma- specific alpha-fetoprotein by isoelectric focusing

1994 • 41 citations

EARLY DETECTION OF PRIMARY HEPATOCELLULAR CARCINOMA BY SCREENING FOR ALPHA-FETOPROTEIN IN HIGH-RISK FAMILIES

1983 • 34 citations

[Radioimmunoassay of alpha fetoprotein].

1973 • 25 citations

[Presence of serum alpha fetoprotein in 4 cases of primary digestive cancers other than hepatomas].

1971 • 21 citations

Germ cell tumors express a specific alpha-fetoprotein variant detectable by isoelectric focusing

1995 • 17 citations