Novel Protective Effects of Stem Cell Factor in a Murine Model of Acute Septic Peritonitis

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice

1998 • 1,022 citations

Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin

1990 • 975 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.

1993 • 504 citations

Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis.

1990 • 447 citations

Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture

1992 • 436 citations

Balance of inflammatory cytokines related to severity and mortality of murine sepsis

1996 • 366 citations

Role of Resident Peritoneal Macrophages and Mast Cells in Chemokine Production and Neutrophil Migration in Acute Inflammation: Evidence for an Inhibitory Loop Involving Endogenous IL-10

1999 • 300 citations

STAT3 Participates in Transcriptional Activation of the C-reactive Protein Gene by Interleukin-6

1996 • 289 citations

Endogenous IL-10 protects mice from death during septic peritonitis.

1995 • 287 citations

Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.

1994 • 285 citations

Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor.

1995 • 284 citations

Stem cell factor is a chemotactic factor for human mast cells.

1994 • 282 citations

The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis.

1994 • 279 citations

The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others.

1993 • 279 citations

Endogenous Monocyte Chemoattractant Protein-1 (MCP-1) Protects Mice in a Model of Acute Septic Peritonitis: Cross-Talk Between MCP-1 and Leukotriene B4

1999 • 236 citations

The Chemokine Monocyte Chemotactic Protein 1 Triggers Janus Kinase 2 Activation and Tyrosine Phosphorylation of the CCR2B Receptor

1998 • 224 citations

The Lipopolysaccharide-Binding Protein Is a Secretory Class 1 Acute-Phase Protein Whose Gene Is Transcriptionally Activated by APRF/STAT-3 and Other Cytokine-Inducible Nuclear Proteins

1996 • 213 citations

IL‐10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes

1996 • 170 citations

Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock

1993 • 166 citations

Regulation of mouse peritoneal mast cell secretory function by stem cell factor, IL-3 or IL-4.

1993 • 154 citations

The c-kit Ligand, Stem Cell Factor, Can Enhance Innate Immunity Through Effects on Mast Cells

1998 • 152 citations

The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function.

1992 • 145 citations

Reversible expansion of primate mast cell populations in vivo by stem cell factor.

1993 • 127 citations

Kupffer cell depletion abolishes induction of interleukin-10 and permits sustained overexpression of tumor necrosis factor alpha messenger RNA in the regenerating rat liver

1997 • 118 citations

Protection against lethal bacterial infection in mice by monocyte-chemotactic and -activating factor

1994 • 111 citations

Interleukin-10 expression is autoregulated at the transcriptional level in human and murine kupffer cells

1998 • 93 citations

Coexpression of Stem Cell Factor andc-kitin Embryonic and Adult Liver

1996 • 75 citations

Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat

1998 • 57 citations

Stem cell factor has histamine releasing activity in rat connective tissue-type mast cells

1992 • 49 citations

Therapeutic Effects of Nitric Oxide Inhibition during Experimental Fecal Peritonitis: Role of Interleukin-10 and Monocyte Chemoattractant Protein 1

1998 • 45 citations

Increase in National Hospital Discharge Survey rates for septicemia--United States, 1979-1987.

1990 • 28 citations

Deleted Work

1955 • 0 citations