Identification of a Negative Regulatory Surface within Estrogen Receptor α Provides Evidence in Support of a Role for Corepressors in Regulating Cellular Responses to Agonists and Antagonists

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

2000 • 1,658 citations

Molecular Determinants for the Tissue Specificity of SERMs

2002 • 1,114 citations

The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1

1999 • 1,055 citations

Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

1998 • 667 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones

1997 • 649 citations

Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen

1997 • 640 citations

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

1999 • 637 citations

Mouse Estrogen Receptor β Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor α

1997 • 610 citations

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

2002 • 588 citations

Molecular determinants of nuclear receptor-corepressor interaction

1999 • 516 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development

2000 • 502 citations

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β

1999 • 405 citations

Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β

1999 • 362 citations

Structural Insights into the Mode of Action of a Pure Antiestrogen

2001 • 342 citations

A Dominant-negative Peroxisome Proliferator-activated Receptor γ (PPARγ) Mutant Is a Constitutive Repressor and Inhibits PPARγ-mediated Adipogenesis

2000 • 265 citations

The Nuclear Corepressors NCoR and SMRT Are Key Regulators of Both Ligand- and 8-Bromo-Cyclic AMP-Dependent Transcriptional Activity of the Human Progesterone Receptor

1998 • 264 citations

Comparative Analyses of Mechanistic Differences Among Antiestrogens1

1999 • 245 citations

Identification of a New Subclass of Alu DNA Repeats Which Can Function as Estrogen Receptor-dependent Transcriptional Enhancers

1995 • 226 citations

Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes

1990 • 189 citations

DAX-1 Functions as an LXXLL-containing Corepressor for Activated Estrogen Receptors

2000 • 183 citations

The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERα and ERβ

1999 • 179 citations

A Nuclear Receptor Corepressor Modulates Transcriptional Activity of Antagonist-Occupied Steroid Hormone Receptor

1998 • 168 citations

Analysis of Estrogen Receptor Interaction with a Repressor of Estrogen Receptor Activity (REA) and the Regulation of Estrogen Receptor Transcriptional Activity by REA

2000 • 140 citations

A Novel Role for Helix 12 of Retinoid X Receptor in Regulating Repression

1999 • 110 citations

TR Surfaces and Conformations Required to Bind Nuclear Receptor Corepressor

2002 • 101 citations

Enhancement of Estrogen Receptor Transcriptional Activity by the Coactivator GRIP-1 Highlights the Role of Activation Function 2 in Determining Estrogen Receptor Pharmacology

1998 • 99 citations

Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells.

1994 • 92 citations

Transcriptional Silencing Is Defined by Isoform- and Heterodimer-Specific Interactions between Nuclear Hormone Receptors and Corepressors

1998 • 74 citations

An issue of tissues: divining the split personalities of selective estrogen receptor modulators

2000 • 58 citations

The Tamoxifen-responsive Estrogen Receptor α Mutant D351Y Shows Reduced Tamoxifen-dependent Interaction with Corepressor Complexes

2001 • 55 citations

Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells

1994 • 39 citations

Hormone-dependent Transactivation by Estrogen Receptor Chimeras That Do Not Interact with hsp90

1996 • 27 citations

Agonist-dependent Repression Mediated by Mutant Estrogen Receptor α That Lacks the Activation Function 2 Core Domain

2001 • 22 citations