Altered Proglucagon Processing in an α-Cell Line Derived from Prohormone Convertase 2 Null Mouse Islets

Caspases: Enemies Within

1998 • 6,923 citations

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

1997 • 782 citations

Insulin Biosynthesis: Evidence for a Precursor

1967 • 699 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

The proprotein convertases

1998 • 648 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Signal sequences: more than just greasy peptides

1998 • 544 citations

Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2

1991 • 475 citations

Proteolytic Processing in the Secretory Pathway

1999 • 455 citations

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

1991 • 449 citations

Enzymes Required for Yeast Prohormone Processing

1988 • 446 citations

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2

1997 • 423 citations

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

1994 • 401 citations

Molecular Identification of the Sterol-Regulated Luminal Protease that Cleaves SREBPs and Controls Lipid Composition of Animal Cells

1998 • 400 citations

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

1989 • 386 citations

Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

1995 • 348 citations

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

2003 • 341 citations

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

2002 • 338 citations

Carboxypeptidase E

1988 • 308 citations

Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide

1995 • 228 citations

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.

1994 • 211 citations

Precursor Convertases: An Evolutionary Ancient, Cell‐Specific, Combinatorial Mechanism Yielding Diverse Bioactive Peptides and Proteins

1998 • 188 citations

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3

2002 • 185 citations

Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats

2000 • 161 citations

Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic a cells

1988 • 161 citations

Severe Defect in Proglucagon Processing in Islet A-cells of Prohormone Convertase 2 Null Mice

2001 • 158 citations

Roles of Ubiquitinylation in Proteolysis and Cellular Regulation

1995 • 150 citations

Proglucagon Processing Similar to Normal Islets in Pancreatic α-Like Cell Line Derived From Transgenic Mouse Tumor

1990 • 134 citations

Impaired Intestinal Proglucagon Processing in Mice Lacking Prohormone Convertase 1

2003 • 114 citations

Role of the Prohormone Convertase PC3 in the Processing of Proglucagon to Glucagon-like Peptide 1

1997 • 109 citations

Regulatory Roles of the P Domain of the Subtilisin-like Prohormone Convertases

1998 • 107 citations

Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas

2002 • 95 citations

Glucagon Replacement via Micro-Osmotic Pump Corrects Hypoglycemia and α-Cell Hyperplasia in Prohormone Convertase 2 Knockout Mice

2002 • 92 citations

Biological Processing of the Cocaine and Amphetamine-regulated Transcript Precursors by Prohormone Convertases, PC2 and PC1/3

2003 • 82 citations

Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: a potential mechanism for its inactivation.

1996 • 80 citations

Enzymic characterization of immunopurified prohormone convertase 2: Potent inhibition by a 7B2 peptide fragment

1995 • 77 citations

Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon

1997 • 71 citations

Cellular Localization and Role of Prohormone Convertases in the Processing of Pro-melanin Concentrating Hormone in Mammals

1999 • 68 citations

Molecular and cellular regulation of prohormone processing

1998 • 63 citations

Abrogation of Protein Convertase 2 Activity Results in Delayed Islet Cell Differentiation and Maturation, Increased α-Cell Proliferation, and Islet Neogenesis

2003 • 63 citations

Expression profiling of pancreatic beta-cells: glucose regulation of secretory and metabolic pathway genes.

2001 • 52 citations

PC5-A-mediated Processing of Pro-neurotensin in Early Compartments of the Regulated Secretory Pathway of PC5-transfected PC12 Cells

1998 • 50 citations

The Role of the 7B2 CT Peptide in the Inhibition of Prohormone Convertase 2 in Endocrine Cell Lines

1999 • 39 citations

Contrasting patterns of expression of transcription factors in pancreatic α and β cells

2003 • 34 citations

Furin and Prohormone Convertase 1/3 Are Major Convertases in the Processing of Mouse Pro-Growth Hormone-Releasing Hormone

2003 • 33 citations

Developmental expression of proprotein convertase 1/3 in the rat

1999 • 28 citations

Neuronal cell lines expressing PC5, but not PC1 or PC2, process Pro-CCK into glycine-extended CCK 12 and 22

2001 • 26 citations

A covalently trapped folding intermediate of subtilisin E: Spontaneous dimerization of a prosubtilisin E Ser49Cys mutant in vivo and its autoprocessing in vitro

1994 • 14 citations