Impaired Intestinal Proglucagon Processing in Mice Lacking Prohormone Convertase 1

Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans

1994 • 868 citations

The proprotein convertases

1998 • 648 citations

Methods in Neurosciences

1992 • 622 citations

The new enzymology of precursor processing endoproteases.

1992 • 608 citations

Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice

2003 • 533 citations

Proteolytic Processing in the Secretory Pathway

1999 • 455 citations

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2

1997 • 423 citations

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

1994 • 401 citations

Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine.

1991 • 371 citations

Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

1995 • 348 citations

GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine

2003 • 340 citations

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

2002 • 338 citations

Gut Peptides

1994 • 268 citations

Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide

1995 • 228 citations

Role of prohormone convertases in the tissue-specific processing of proglucagon.

1996 • 224 citations

Structure, measurement, and secretion of human glucagon-like peptide-2

2000 • 212 citations

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.

1994 • 211 citations

Pancreatic and intestinal processing of proglucagon in man

1987 • 203 citations

Identification and Functional Expression of a New Member of the Mammalian Kex2-Like Processing Endoprotease Family: Its Striking Structural Similarity to PACE41

1993 • 185 citations

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3

2002 • 185 citations

Severe Defect in Proglucagon Processing in Islet A-cells of Prohormone Convertase 2 Null Mice

2001 • 158 citations

Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas.

1990 • 154 citations

The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments.

1996 • 150 citations

Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation.

1995 • 133 citations

Evidence that glicentin contains the entire sequence of glucagon

1980 • 113 citations

Role of the Prohormone Convertase PC3 in the Processing of Proglucagon to Glucagon-like Peptide 1

1997 • 109 citations

Potential Therapeutic Levels of Glucagon-Like Peptide I Achieved in Humans by a Buccal Tablet

1996 • 95 citations

Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.

1994 • 87 citations

Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms

1994 • 80 citations

Processing of Mouse Proglucagon by Recombinant Prohormone Convertase 1 and Immunopurified Prohormone Convertase 2 in Vitro

1995 • 78 citations

Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon

1997 • 71 citations

Assays for Peptide Products of Somatostatin Gene Expression

1991 • 67 citations

Proglucagon Processing Profile in Canine L Cells Expressing Endogenous Prohormone Convertase 1/3 and Prohormone Convertase 2

1999 • 44 citations

Distribution of the Kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets.

1995 • 31 citations

Evidence for redundancy in propeptide/prohormone convertase activities in processing proglucagon: an antisense study.

1996 • 31 citations

Immunological detection of prohormone convertases in two different proglucagon processing cell lines

1994 • 19 citations

The Insulinotropic Gut Hormone Glucagon-Like Peptide-1

1997 • 19 citations

Posttranslational Processing of Proglucagon and Postsecretory Fate of Proglucagon Products

1997 • 10 citations