Furin and Prohormone Convertase 1/3 Are Major Convertases in the Processing of Mouse Pro-Growth Hormone-Releasing Hormone

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Furin at the cutting edge: From protein traffic to embryogenesis and disease

2002 • 1,162 citations

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1997 • 1,125 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

The new enzymology of precursor processing endoproteases.

1992 • 608 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2

1991 • 475 citations

Proteolytic Processing in the Secretory Pathway

1999 • 455 citations

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

1991 • 449 citations

Enzymes Required for Yeast Prohormone Processing

1988 • 446 citations

Growth Hormone-Releasing Hormone*

1986 • 427 citations

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2

1997 • 423 citations

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

1994 • 401 citations

Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease

1989 • 395 citations

Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

1995 • 348 citations

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

2003 • 341 citations

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

2002 • 338 citations

Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3.

1992 • 300 citations

Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor.

1984 • 288 citations

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

1991 • 268 citations

The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing.

1993 • 259 citations

Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.

1992 • 249 citations

Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis

1993 • 236 citations

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases.

1996 • 236 citations

The distribution of growth‐hormone‐releasing factor (GRF) immunoreactivity in the central nervous system of the rat: An immunohistochemical study using antisera directed against rat hypothalamic GRF

1985 • 234 citations

Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide

1995 • 228 citations

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

1993 • 223 citations

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

1990 • 219 citations

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.

1986 • 207 citations

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.

1992 • 203 citations

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3

2002 • 185 citations

Identification and Functional Expression of a New Member of the Mammalian Kex2-Like Processing Endoprotease Family: Its Striking Structural Similarity to PACE41

1993 • 185 citations

Incomplete Processing of Proinsulin to Insulin Accompanied by Elevation of Des-31,32 Proinsulin Intermediates in Islets of Mice Lacking Active PC2

1998 • 180 citations

Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation

1997 • 173 citations

Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor

1983 • 172 citations

Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin.

1983 • 169 citations

Growth Hormone-Releasing Hormone: Synthesis and Signaling

1995 • 159 citations

Severe Defect in Proglucagon Processing in Islet A-cells of Prohormone Convertase 2 Null Mice

2001 • 158 citations

7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity.

1995 • 155 citations

Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.

1993 • 151 citations

The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments.

1996 • 150 citations

Prodynorphin Processing by Proprotein Convertase 2

1998 • 148 citations

fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas.

1987 • 144 citations

Characterization of cDNA and genomic clones encoding the precursor to rat hypothalamic growth hormone-releasing factor

1985 • 136 citations

Consensus sequence for precursor processing at mono-arginyl sites. Evidence for the involvement of a Kex2-like endoprotease in precursor cleavages at both dibasic and mono-arginyl sites.

1992 • 116 citations

Specificity of Prohormone Convertase 2 on Proenkephalin and Proenkephalin-related Substrates

1998 • 104 citations

A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.

1996 • 102 citations

A Second Mutant Allele of Furin in the Processing-incompetent Cell Line, LoVo

1995 • 101 citations

Cloning and Characterization of Mouse Growth Hormone-Releasing Hormone (GRH) Complementary DNA: Increased GRH Messenger RNA Levels in the Growth Hormone-Deficient lit/lit Mouse

1989 • 98 citations

Cloning and Functional Expression of a Novel Endoprotease Involved in Prohormone Processing at Dibasic Sites1

1991 • 96 citations

Mouse Growth Hormone-Releasing Hormone: Precursor Structure and Expression in Brain and Placenta

1989 • 95 citations

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

1996 • 92 citations

Differences in pH Optima and Calcium Requirements for Maturation of the Prohormone Convertases PC2 and PC3 Indicates Different Intracellular Locations for These Events

1995 • 88 citations

Defective Prodynorphin Processing in Mice Lacking Prohormone Convertase PC2

2000 • 86 citations

The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase.

1994 • 86 citations

Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary

1995 • 83 citations

PC8 [corrected], a new member of the convertase family

1996 • 82 citations

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase

1992 • 82 citations

Biological Processing of the Cocaine and Amphetamine-regulated Transcript Precursors by Prohormone Convertases, PC2 and PC1/3

2003 • 82 citations

Processing of Prothyrotropin-releasing Hormone by the Family of Prohormone Convertases

1997 • 80 citations

Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells.

1995 • 80 citations

Proparathyroid Hormone Is Preferentially Cleaved to Parathyroid Hormone by the Prohormone Convertase Furin

1995 • 78 citations

Cellular Localization and Role of Prohormone Convertases in the Processing of Pro-melanin Concentrating Hormone in Mammals

1999 • 68 citations

Mortality in 7B2 null mice can be rescued by adrenalectomy: Involvement of dopamine in ACTH hypersecretion

2002 • 64 citations

The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates

1995 • 57 citations

Differential distribution of mannose-6-phosphate receptors and furin in immature secretory granules

1999 • 56 citations

Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study

2002 • 51 citations

PC5-A-mediated Processing of Pro-neurotensin in Early Compartments of the Regulated Secretory Pathway of PC5-transfected PC12 Cells

1998 • 50 citations

The testicular germ-cell protease PC4 is also expressed in macrophage-like cells of the ovary

2001 • 47 citations

Processing of proSAAS in neuroendocrine cell lines

2002 • 45 citations

Tissue distribution and processing of proSAAS by proprotein convertases

2001 • 43 citations

Structure of the Gene for the Testis-Specific Proprotein Convertase 4 and of Its Alternate Messenger RNA Isoforms

1994 • 40 citations

PACE4: a subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status.

1994 • 38 citations

Sequence Requirements for Endoproteolytic Processing of Precursor Proteins by Fur in: Transfection and In Vitro Experiments1

1994 • 34 citations

The Enzymology of PC1 and PC2

2002 • 34 citations

Processing of proSAAS in neuroendocrine cell lines

2001 • 27 citations

Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain

2000 • 27 citations

Neuronal cell lines expressing PC5, but not PC1 or PC2, process Pro-CCK into glycine-extended CCK 12 and 22

2001 • 26 citations

Processing of chromogranin A by bovine parathyroid secretory granules: production and secretion of N-terminal fragments.

1994 • 26 citations

Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: requirement for secretory cell but not the secretion granule

1995 • 24 citations

Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1)

2003 • 21 citations

Developmental expression of a novel Kexin family protease, PACE4E, in the rat olfactory system

1997 • 19 citations

CLEAVAGE AT SINGLE BASIC RESIDUES AND ENHANCED PROCESSING IN THE PRESENCE OF CARBOXYPEPTIDASE ACTIVITY

1998 • 18 citations

Characterization and Localization of Mouse Hypothalamic Growth Hormone‐Releasing Factor and Effect of Gold Thioglucose‐Induced Hypothalamic Lesions

1994 • 15 citations

Production, Purification, and Characterization of Recombinant Prohormone Convertase 5 from Baculovirus-Infected Insect Cells

2002 • 15 citations

The Prohormone Convertases and Precursor Processing in Protein Biosynthesis

2002 • 9 citations

Structural and Functional Analysis of the Protein Products Derived From Mutant fur Alleles in an Endoprotease-Deficient Chinese Hamster Ovary Cell Strain

1998 • 5 citations