ATP-binding cassette, subfamily G (ABCG family)

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

2001 • 2,274 citations

A multidrug resistance transporter from human MCF-7 breast cancer cells

1998 • 2,273 citations

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

2000 • 1,626 citations

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

2001 • 1,116 citations

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

2004 • 1,036 citations

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

2003 • 1,027 citations

Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β

2002 • 822 citations

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation

2005 • 820 citations

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

2002 • 807 citations

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

1998 • 798 citations

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

2002 • 754 citations

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

2002 • 708 citations

Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

2001 • 683 citations

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

2002 • 682 citations

The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme

2004 • 648 citations

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

2001 • 643 citations

Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ

2004 • 557 citations

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

2000 • 540 citations

The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

2000 • 528 citations

Bcrp1gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cellsin vivo

2002 • 506 citations

Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.

2000 • 494 citations

Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.

1999 • 475 citations

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

2002 • 432 citations

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

2001 • 427 citations

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk

2005 • 412 citations

Conditional Disruption of the Peroxisome Proliferator-Activated Receptor γ Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholesterol Efflux

2002 • 370 citations

The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.

1999 • 353 citations

ROLE OF ABCG2/BCRP IN BIOLOGY AND MEDICINE

2005 • 351 citations

Two Genes That Map to the STSL Locus Cause Sitosterolemia: Genomic Structure and Spectrum of Mutations Involving Sterolin-1 and Sterolin-2, Encoded by ABCG5 and ABCG8, Respectively

2001 • 350 citations

The Effect of Bcrp1 (Abcg2) on the In vivo Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors to Enable the Brain Penetration of Imatinib in Patients

2005 • 348 citations

High-Affinity Interaction of Tyrosine Kinase Inhibitors with the ABCG2 Multidrug Transporter

2004 • 338 citations

Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.

2001 • 338 citations

ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics

2003 • 336 citations

Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2

2003 • 309 citations

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

2002 • 308 citations

Dominant‐negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S‐S dependent homodimerization

2001 • 292 citations

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine

2003 • 274 citations

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

2002 • 268 citations

Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2

2004 • 266 citations

FUNCTIONAL ASSESSMENT OFABCG2(BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA

2004 • 265 citations

ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins

2005 • 262 citations

Functional Analysis of SNPs Variants of BCRP/ABCG2

2004 • 257 citations

Characterization of the Human ABCG1 Gene

2001 • 256 citations

Role of ABCG1 and other ABCG family members in lipid metabolism

2001 • 256 citations

Involvement of BCRP (ABCG2) in the Biliary Excretion of Pitavastatin

2005 • 253 citations

Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males

2006 • 247 citations

Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.

2002 • 244 citations

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype*1

2004 • 241 citations

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

2003 • 234 citations

Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles

2004 • 229 citations

The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes.

1988 • 224 citations

Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene

2001 • 223 citations

The Breast Cancer Resistance Protein (BCRP/ABCG2) Affects Pharmacokinetics, Hepatobiliary Excretion, and Milk Secretion of the Antibiotic Nitrofurantoin

2005 • 220 citations

Identification of a Novel Estrogen Response Element in the Breast Cancer Resistance Protein ( ABCG2 ) Gene

2004 • 216 citations

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter.

2003 • 216 citations

Identification of BCRP as transporter of benzo[ a ]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists

2005 • 213 citations

The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins

2005 • 208 citations

ABCG2 Pharmacogenetics

2004 • 205 citations

Expression and functional characterization of ABCG2 in brain endothelial cells and vessels

2003 • 200 citations

BREAST CANCER RESISTANCE PROTEIN (BCRP/ABCG2) TRANSPORTS FLUOROQUINOLONE ANTIBIOTICS AND AFFECTS THEIR ORAL AVAILABILITY, PHARMACOKINETICS, AND MILK SECRETION

2006 • 196 citations

Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2).

2002 • 196 citations

Estrogen-Mediated Post transcriptional Down-regulation of Breast Cancer Resistance Protein/ABCG2

2005 • 164 citations

Expression and Regulation of Multiple Murine ATP-binding Cassette Transporter G1 mRNAs/Isoforms That Stimulate Cellular Cholesterol Efflux to High Density Lipoprotein

2004 • 164 citations

Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk

2005 • 154 citations

Breast Cancer Resistance Protein (Bcrp/abcg2) Is a Major Determinant of Sulfasalazine Absorption and Elimination in the Mouse

2006 • 153 citations

Sitosterolemia in ABC-Transporter G5-deficient mice is aggravated on activation of the liver-X receptor

2003 • 150 citations

A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol

2004 • 149 citations

Regulation of BCRP/ABCG2 expression by progesterone and 17β-estradiol in human placental BeWo cells

2005 • 144 citations

Identification of genes differentially expressed in breast cancer cells treated with tamoxifen, using microarray-based expression profiling

2001 • 129 citations

Complement-Mediated Mechanisms in Anti-GD2 Monoclonal Antibody Therapy of Murine Metastatic Cancer

2005 • 127 citations

Cloning and characterization of the scarlet gene of Drosophila melanogaster.

1989 • 126 citations

Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux.

2000 • 126 citations

Reversal of breast cancer resistance protein (BCRP/ABCG2)‐mediated drug resistance by novobiocin, a coumermycin antibiotic

2003 • 120 citations

Identification of Intra- and Intermolecular Disulfide Bridges in the Multidrug Resistance Transporter ABCG2

2005 • 119 citations

A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport

2003 • 119 citations

Investigation of Efflux Transport of Dehydroepiandrosterone Sulfate and Mitoxantrone at the Mouse Blood-Brain Barrier: A Minor Role of Breast Cancer Resistance Protein

2004 • 119 citations

Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3.

1996 • 106 citations

The Human ABCG4 Gene Is Regulated by Oxysterols and Retinoids in Monocyte-Derived Macrophages

2001 • 100 citations

Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols

2006 • 98 citations

Isolation and characterization of a mammalian homolog of the Drosophila white gene

1997 • 96 citations

Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.

2004 • 83 citations

Purine transport by Malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster

1979 • 81 citations

Role of Breast Cancer Resistance Protein (Bcrp1/Abcg2) in the Extrusion of Glucuronide and Sulfate Conjugates from Enterocytes to Intestinal Lumen

2004 • 81 citations

Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8

2002 • 78 citations

Genomic Sequence and Structure of the Human ABCG1 (ABC8) Gene

2001 • 70 citations

Induction of Hepatic Transporters Multidrug Resistance-Associated Proteins (Mrp) 3 and 4 by Clofibrate Is Regulated by Peroxisome Proliferator-Activated Receptor α

2006 • 70 citations

Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene

1996 • 69 citations

Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8

2002 • 69 citations

ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates

2005 • 61 citations

Comparative genome analysis of potential regulatory elements in the ABCG5–ABCG8 gene cluster

2002 • 57 citations

Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4

2001 • 50 citations

Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene

2000 • 50 citations

The Brown Protein of Drosophila melanogaster is Similar to the White Protein and to Components of Active Transport Complexes

1988 • 49 citations

Phenomenology and Scientific Progress

2002 • 47 citations

Determination of trace elements in serum by dynamic reaction cell inductively coupled plasma mass spectrometry

2006 • 39 citations

An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domain

2001 • 36 citations

Lack of Improvement of Oral Absorption of ME3277 by Prodrug Formation Is Ascribed to the Intestinal Efflux Mediated by Breast Cancer Resistant Protein (BCRP/ABCG2)

2005 • 29 citations

Genetic disorders associated with ATP binding cassette cholesterol transporters

2002 • 15 citations