Lack of Improvement of Oral Absorption of ME3277 by Prodrug Formation Is Ascribed to the Intestinal Efflux Mediated by Breast Cancer Resistant Protein (BCRP/ABCG2)

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

2003 • 1,027 citations

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

2002 • 807 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

THE MAMMALIAN CARBOXYLESTERASES: From Molecules to Functions

1998 • 730 citations

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

2000 • 640 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

2001 • 438 citations

ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics

2003 • 336 citations

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

1999 • 292 citations

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

2000 • 288 citations

Functional Analysis of SNPs Variants of BCRP/ABCG2

2004 • 257 citations

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

2003 • 234 citations

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

2003 • 183 citations

Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.

2004 • 83 citations

Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro.

2003 • 82 citations

Influence of anesthetic regimens on intestinal absorption in rats.

1993 • 50 citations

A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug.

2000 • 40 citations

Polarized efflux of mono- and diacid metabolites of ME3229, an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist, in rat small intestine.

2000 • 17 citations

Measurement of intestinal absorption in mice by a double-label radioisotope perfusion technic.

1976 • 5 citations