Recombinant activated factor VII (rFVIIa) as a hemostatic agent in liver disease: A break from convention in need of controlled trials

Transection of the oesophagus for bleeding oesophageal varices

1973 • 7,698 citations

A model to predict survival in patients with end-stage liver disease

2001 • 4,580 citations

A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts

2000 • 2,746 citations

Early indicators of prognosis in fulminant hepatic failure

1989 • 2,064 citations

Management of adult patients with ascites caused by cirrhosis

1998 • 509 citations

Guidelines on the use of liver biopsy in clinical practice

1999 • 482 citations

THROMBELASTOGRAPHY

1992 • 438 citations

Hepatic and portal vein thrombosis in cirrhosis: Possible role in development of parenchymal extinction and portal hypertension

1995 • 422 citations

The Tissue Factor Pathway: How It Has Become a “Prima Ballerina”

1995 • 419 citations

Bleeding after liver biopsy does not correlate with indices of peripheral coagulation

1981 • 350 citations

Clinical and statistical validity of conventional prognostic factors in predicting short-term survival among cirrhotics

1987 • 323 citations

Recombinant factor VIIa corrects prothrombin time in cirrhotic patients: A preliminary study

1997 • 263 citations

Pharmacokinetics and pharmacodynamics of recombinant factor VIIa

1994 • 256 citations

REDUCED TRANSFUSION REQUIREMENTS BY RECOMBINANT FACTOR VIIa IN ORTHOTOPIC LIVER TRANSPLANTATION

2001 • 250 citations

Recombinant activated factor VII for coagulopathy in fulminant hepatic failure compared with conventional therapy

2003 • 239 citations

Hemostasis and Fibrinolysis in Severe Liver Failure and Their Relation to Hemorrhage

1986 • 191 citations

Splanchnic and systemic hemodynamics in portal hypertensive rats during hemorrhage and blood volume restitution

1986 • 178 citations

Hepatic and portal vein thrombosis in cirrhosis: Possible role in development of parenchymal extinction and portal hypertension*1, *2

1995 • 175 citations

Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver?

1997 • 165 citations

Safety and efficacy of recombinant factor VIIa in patients with liver disease undergoing laparoscopic liver biopsy

2002 • 162 citations

Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict

2001 • 149 citations

Prothrombin time in liver failure: Time, ratio, activity percentage, or international normalized ratio

1996 • 148 citations

Prothrombin time in liver failure: Time, ratio, activity percentage, or international normalized ratio

1996 • 145 citations

High‐dose factor VIIa increases initial thrombin generation and mediates faster platelet activation in thrombocytopenia‐like conditions in a cell‐based model system

2001 • 142 citations

Inhibition of factor VIIa/tissue factor-induced blood coagulation: with particular emphasis upon a factor Xa-dependent inhibitory mechanism

1989 • 141 citations

Effects of Blood Volume Restitution Following A Portal Hypertensive-Related Bleeding in Anesthetized Cirrhotic Rats

2001 • 138 citations

A prospective randomized comparison between small bowel enteroclysis and small bowel follow-through in Crohn's disease

1997 • 138 citations

Recombinant Activated Factor VII (rFVIIa) Acutely Normalizes Prothrombin Time in Patients with Cirrhosis During Bleeding from Oesophageal Varices

2001 • 136 citations

Percutaneous Cannulation of the Internal Jugular Vein in Patients with Coagulopathies

1982 • 133 citations

Coagulation defects in liver disease

1994 • 132 citations

Assessment of the Validity of the INR System for Patients with Liver Impairment

1994 • 121 citations

The pathogenesis of accelerated fibrinolysis in liver cirrhosis: a critical role for tissue plasminogen activator inhibitor

1987 • 119 citations

Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men

2003 • 96 citations

Quick correction of hemostasis in two patients with fulminant liver failure undergoing liver transplantation by recombinant activated factor VII

1999 • 89 citations

New Insights into the Coagulation System and Implications for New Therapeutic Options with Recombinant Factor VIIa

2003 • 84 citations

Coagulopathy of Fulminant Hepatic Failure

1986 • 81 citations

Abnormal Fibrin Polymerization in Liver Disease

1976 • 80 citations

Recombinant Coagulation Factor VIIa: From the Concept to Clinical Application in Hemophilia Treatment in 2000

2000 • 76 citations

Recombinant factor VIIa improves clot formation but not fibrolytic potential in patients with cirrhosis and during liver transplantation

2002 • 74 citations

Effects of recombinant activated factor VII on coagulation measured by thromboelastography in liver transplantation

2002 • 70 citations

Variation between centers in technique and guidelines for liver biopsy

1996 • 69 citations

Recombinant-activated factor VII as hemostatic therapy in eight cases of severe hemorrhage from esophageal varices

2004 • 68 citations

Platelet function in chronic liver disease

1979 • 67 citations

Invasive line placement in critically ill patients: do hemostatic defects matter?

1996 • 61 citations

Percutaneous liver biopsy: what is the current approach? Results of a questionnaire survey.

2001 • 58 citations

Hematologic aspects of end-stage renal failure

1994 • 54 citations

Disseminated intravascular coagulation in liver cirrhosis

1992 • 48 citations

Transfusion Therapy: Clinical Principles And Practice

2005 • 46 citations

rVIIa therapy to secure haemostasis during central line insertion in children with high‐responding FVIII inhibitors

1996 • 32 citations

Use and validation of selection criteria for liver transplantation in acute liver failure

2000 • 31 citations

Use of activated recombinant human factor VII (rhFVIIa) for colonic polypectomies in patients with cirrhosis and coagulopathy.

2003 • 31 citations

Differentiation of autoimmune thrombocytopenia from thrombocytopenia associated with immune complex disease: systemic lupus erythematosus, hepatitis‐cirrhosis, and HIV‐1 infection by platelet and serum immunological measurements

1999 • 26 citations

Use of recombinant factor VIIa to treat persistent bleeding following dental extractions in two cirrhotic patients

2002 • 24 citations

Controlling Pain in Liver Biopsy, or “We Will Probably Need to Repeat the Biopsy in a Year or Two to Assess the Response”

2001 • 21 citations

Efficacy of activated recombinant factor VII (rFVIIa; novoseven) in cirrhotic patients with upper gastrointestinal bleeding: A randomized placebo-controlled double-blind multicenter trial

2003 • 8 citations

806 The effect of recombinant factor VIIA and fresh frozen plasma on the INR in patients with acute and chronic liver failure

2003 • 7 citations

Deleted Work

1955 • 0 citations