The pathogenesis of accelerated fibrinolysis in liver cirrhosis: a critical role for tissue plasminogen activator inhibitor

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

1985 • 1,364 citations

Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.

1981 • 792 citations

A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma

1982 • 486 citations

Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

1983 • 400 citations

Demonstration of a fast-acting inhibitor of plasminogen activators in human plasma

1984 • 382 citations

Detection and partial characterization of an inhibitor of plasminogen activator in human platelets.

1984 • 365 citations

Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma

1984 • 345 citations

Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells.

1986 • 310 citations

Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium

1985 • 305 citations

Significance of Cross-Linking of α2-Plasmin Inhibitor to Fibrin in Inhibition of Fibrinolysis and in Hemostasis

1982 • 287 citations

Plasma levels of a specific inhibitor of tissue-type plasminogen activator (and urokinase) in normal and pathological conditions

1984 • 240 citations

Abnormal Plasminogen-Plasmin System Activity (Fibrinolysis) in Patients with Hepatic Cirrhosis: Its Cause and Consequences*

1964 • 238 citations

An Enzyme Linked Immunosorbent Assay for Determination of Tissue Plasminogen Activator Applied to Patients with Thromboembolic Disease

1983 • 211 citations

The role of the fibrinolytic system in deep vein thrombosis.

1985 • 201 citations

Inactivation of tissue plasminogen activator in plasma. Demonstration of a complex with a new rapid inhibitor.

1984 • 193 citations

Turnover of Human Extrinsic (Tissue-Type) Plasminogen Activator in Rabbits

1981 • 184 citations

Purification of a Specific Placental Plasminogen Activator Inhibitor by Monoclonal Antibody and Its Complex Formation with Plasminogen Activator

1985 • 161 citations

Kinetic and functional studies of platelets, fibrinogen, and plasminogen in patients with hepatic cirrhosis.

1982 • 132 citations

Metabolism of Fibrinogen in Cirrhosis of the Liver

1971 • 117 citations

The α2-plasmin inhibitor levels in liver diseases

1978 • 102 citations

Plasminogen activators in alcoholic cirrhosis: demonstration of increased tissue type and urokinase type activator.

1984 • 92 citations

Clinical Significance of Accelerated Fibrinolysis in Liver Disease

1984 • 74 citations

Masking of Fibrinolytic Response to Stimulation by an Inhibitor of Tissue-Type Plasminogen Activator in Plasma

1984 • 63 citations

Bioimmunoassay (BIA) of Tissue Plasminogen Activator (t-PA) and Its Specific Inhibitor (t-PA/INH)

1985 • 62 citations

Release of vascular plasminogen activator (v‐PA) after venous stasis: electrophoretic—zymographic analysis of free and complexed v‐PA

1985 • 56 citations

Studies on a proteolytic enzyme in human plasma; the rate of lysis of plasma clots in normal and diseased individuals, with particular reference to hepatic diseases.

1949 • 42 citations

Synthesis and secretion of alpha 2-plasmin inhibitor by established human liver cell lines.

1982 • 37 citations

Selective determination of α2-plasmin inhibitor activity in plasma using chromogenic substrate

1984 • 31 citations

A lysine-absorbable plasminogen activator is elevated in conditions associated with increased fibrinolytic activity.

1981 • 30 citations

Urokinase Antigen in Plasma of Patients with Liver Cirrhosis and Hepatoma

1985 • 24 citations

A Sensitive Assay, Specific for Endothelial Cell Type Plasminogen Activator Inhibitor in Blood Plasma

1986 • 20 citations