Recombinant Coagulation Factor VIIa: From the Concept to Clinical Application in Hemophilia Treatment in 2000

Twenty‐five years' experience of prophylactic treatment in severe haemophilia A and B

1992 • 958 citations

Platelet activity of high‐dose factor VIIa is independent of tissue factor

1997 • 544 citations

Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation

1993 • 505 citations

Prospective, Randomised Trial of Two Doses of rFVIIa (NovoSeven) in Haemophilia Patients with Inhibitors Undergoing Surgery

1998 • 379 citations

Home Treatment of Mild to Moderate Bleeding Episodes Using Recombinant Factor VIIa (Novoseven) in Haemophiliacs with Inhibitors

1998 • 362 citations

Fibrin in human plasma: Gel architectures governed by rate and nature of fibrinogen activation

1994 • 266 citations

Recombinant factor VIIa corrects prothrombin time in cirrhotic patients: A preliminary study

1997 • 263 citations

A randomized, double‐blind comparison of two dosage levels of recombinant factor VIIa in the treatment of joint, muscle and mucocutaneous haemorrhages in persons with haemophilia A and B, with and without inhibitors

1998 • 219 citations

Clinical Experience with Recombinant Factor VIla in Patients with Thrombocytopenia

1996 • 195 citations

Measurement of basal levels of factor VIIa in hemophilia A and B patients [see comments]

1992 • 166 citations

Thrombogenicity associated with factor IX complex concentrates.

1991 • 154 citations

Factor VIIa in the treatment of haemophilia

1990 • 130 citations

Autoplex versus proplex: a controlled, double-blind study of effectiveness in acute hemarthroses in hemophiliacs with inhibitors to factor VIII

1983 • 125 citations

Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease.

1989 • 100 citations

The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleedings in patients with haemophilia A with an inhibitor to Factor VIII

1982 • 90 citations

Structural Studies of Fibrinolysis by Electron and Light Microscopy

1999 • 79 citations

Human monocytes support factor X activation by factor VIIa, independent of tissue factor: implications for the therapeutic mechanism of high- dose factor VIIa in hemophilia [see comments]

1994 • 72 citations

The incidence of factor VIII inhibitors in patients with severe hemophilia A

1995 • 71 citations

Clinical Experience with Human Plasma-Derived Factor VIla in Patients with Hemophilia A and High Titer Inhibitors

1989 • 45 citations

Various Prothrombin Complex Concentrates and their Effect on Coagulation and Fibrinolysis In Vivo

1976 • 41 citations

Clinical update on the use of recombinant factor VII

1995 • 38 citations

Studies on the Thrombogenic Activities in Two Prothrombin Complex Concentrates

1979 • 38 citations

Inhibitors to Coagulation Factors

1995 • 34 citations

On the Coagulation of Platelet-Rich Plasma

1999 • 12 citations

Measurement of the procoagulant activity of factor VII in patients with liver cirrhosis and normal prothrombin activity: evaluation of the bleeding risk

2000 • 11 citations

Factor VIIa used in critically wounded

1999 • 7 citations