V_λ and J_λ‐C_λ gene segments of the human immunoglobulin λ light chain locus are separated by 14 kb and rearrange by a deletion mechanism

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

Rapid transfer of DNA from agarose gels to nylon membranes

1985 • 1,810 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

V(D)J recombination: a functional definition of the joining signals.

1989 • 467 citations

Clustered arrangement of immunoglobulin λ constant region genes in man

1981 • 379 citations

[1] High-efficiency cloning of full-length cDNA; Construction and screening of cDNA expression libraries for mammalian cells

1987 • 329 citations

Molecular Cloning: A Laboratory Manual 2

1989 • 327 citations

λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

1986 • 302 citations

Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes

1982 • 292 citations

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1982 • 278 citations

A uniform deleting element mediates the loss of κ genes in human B cells

1985 • 259 citations

Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing

1982 • 235 citations

Organization and evolution of variable region genes of the human immunoglobulin heavy chain

1986 • 227 citations

Structure and expression of the human immunoglobulin lambda genes.

1990 • 163 citations

DNA Elements Are Asymmetrically Joined During the Site-Specific Recombination of Kappa Immunoglobulin Genes

1985 • 152 citations

Variable amplification of immunoglobulin λ light-chain genes in human populations

1983 • 142 citations

The isolation of a human Ig Vλ gene from a recombinant library of chromosome 22 and estimation of its copy number

1984 • 94 citations

A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation.

1989 • 92 citations

Lorist2, a cosmid with transcriptional terminators insulating vector genes from interference by promoters within the insert: effect on DNA yield and cloned insert frequency

1987 • 91 citations

Mutational hot spots in Ig V region genes of human follicular lymphomas.

1988 • 86 citations

Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes.

1987 • 85 citations

Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species.

1988 • 84 citations

Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups

1990 • 84 citations

Human ? light chain locus: Organization and DNA sequences of three genomicJ regions

1987 • 77 citations

Identification of three new Ig lambda-like genes in man.

1986 • 76 citations

Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement.

1985 • 73 citations

The V_ϰ gene repertoire in the human germ line

1990 • 70 citations

Contribution of human VκII germ-line genes to light-chain diversity

1984 • 65 citations

The human Vκ locus

1987 • 59 citations

Activation of an Excluded Immunoglobulin Allele in a Human B Lymphoma Cell Line

1989 • 58 citations

Molecular cloning of a human immunoglobulin λ chain variable sequence

1984 • 52 citations

Linking of the human immunoglobulin V_KJ_KC_Kregions by chromosomal walking

1987 • 49 citations

The human V pre B gene is located on chromosome 22 near a cluster of $${\text{V}}_{\lambda _1 } $$ gene segments

1988 • 46 citations

Immunoglobulin Light-Chain Genes of the κ Type in Man and Mouse

1989 • 44 citations

Megabase inversions in the human genome as physiological events

1990 • 42 citations

First nucleotide sequence of a human immunoglobulin variable λ gene belonging to subgroup II

1989 • 41 citations

First genomic sequence of a human Ig variable λ gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus

1989 • 36 citations

Constant-Region Genes of the Immunoglobulin Heavy Chain and the Molecular Mechanism of Class Switching

1989 • 35 citations

Organization and Expression of the Mammalian Heavy-Chain Variable-Region Locus

1989 • 33 citations

Serologically defined V region subgroups of human lambda light chains.

1987 • 32 citations

Cloning and sequence analysis of an Ig λ light chain mRNA expressed in the Burkitt's lymphoma cell line EB4

1985 • 32 citations

Complementary DNA for a human subgroup IV immunoglobulin λ-chain

1987 • 29 citations

Cloning and sequencing of a rearranged V_λgene from a Burkitt's tymphoma cell line expressing kappa light chains

1985 • 27 citations

First genomic sequence of a human lg variable lambda gene belonging to subgroup III

1990 • 27 citations

Genomic sequence of IGLV1S2, a human immunoglobulin variable lambda gene belonging to subgroup I

1990 • 26 citations

Nucleotide sequences of the cDNAs encoding the V-regions of H- and L-chains of a human monoclonal antibody with broad reactivity to malignant tumor cells

1989 • 15 citations

Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences

1988 • 14 citations

Immunoglobulin λ Genes

1989 • 5 citations