The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression

Psychopharmacology: The Fourth Generation of Progress

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Interleukin-6 and the acute phase response

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Evidence for an immune response in major depression: A review and hypothesis

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Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

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The macrophage theory of depression

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THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY

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Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression

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NEUTRAL AMINO ACIDS IN THE BRAIN: CHANGES IN RESPONSE TO FOOD INGESTION

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THE EFFECTS OF PRECURSOR LOADING IN THE CEREBRAL METABOLISM OF 5‐HYDROXYINDOLES

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Indicators of immune activation in major depression

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Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation.

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Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: Further evidence for an immune response

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Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep

1987 • 284 citations

Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages

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Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

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Cytokine Production and Serum Proteins in Depression

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Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat

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Effects of sleep deprivation on human immune functions

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Depression, immunocompetence, and prostaglandins of the E series

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Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls

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Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression

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The biology of interleukin 1 and comparison to tumor necrosis factor

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Increased serum interleukin-1-receptor-antagonist concentrations in major depression

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Sleep Disturbances in Men with Asymptomatic Human Immunodeficiency (HIV) Infection

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Modulation of Quinolinic and Kynurenic Acid Content in the Rat Brain: Effects of Endotoxins and Nicotinylalanine

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Impaired Lymphocyte Stimulation by Mitogens in Severely Depressed Patients

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Production of Proinflammatory Cytokines and Cytokines Involved in the TH1/TH2 Balance Is Modulated by Pentoxifylline

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Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin 2.

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The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to l-tryptophan

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Serotonin-immune interactions in major depression: lower serum tryptophan as a marker of an immune-inflammatory response

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Neutrophil and monocyte phagocytosis in depressed patients

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Lower Serum L-Tryptophan Availability in Depression as a Marker of a More Generalized Disorder in Protein Metabolism

1996 • 70 citations

Interleukin-1 Receptors

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Induction of cytokine synthesis and fever suppresses REM sleep and improves mood in patients with major depression

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Concentration and microheterogeneity glycophorms of alpha-1-acid glycoprotein in major depressive disorder

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Abnormal zymosan-induced neutrophil chemiluminescence as a marker of depression

1990 • 50 citations

The effect of olfactory bulbectomy in the rat, alone or in combination with antidepressants and endogenous factors, on immune function

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Effect of interleukin-1 beta on EEG power density during sleep depends on circadian phase

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Influenza virus-induced changes in rabbit sleep and acute phase responses

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Interleukin 1 alpha and an interleukin 1 beta fragment are somnogenic

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Effects of dexamethasone on the availability of l-tryptophan and on the insulin and FFA concentrations in unipolar depressed patients

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Psychoneuroimmunology

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Changes in hypothalamic prostaglandin E2 may predict the occurrence of sleep or wakefulness as assessed by parallel EEG and microdialysis in the rat

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Effects of l-tryptophan and other amino acids on electroencephalographic sleep in the rat

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Age-related changes of the antigen-specific antibody formation in vitro and PHA-induced T-cell proliferation in individuals who met the health criteria of the senieur protocol

1992 • 21 citations

The relationships between the availability ofL-tryptophan to the brain, the spontaneous HPA-axis activity, and the HPA-axis responses to dexamethasone in depressed patients

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Treatment of Severe Chronic Insomnia with L-Tryptophan and Varying Sleeping Times

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Tryptophan Transport to the Brain: Newer Findings and Older Ones Reconsidered

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Signal transduction mechanism of interleukin 6 in cultured rat mesangial cells

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Tryptophan Availability and Serotonin Synthesis in Rat Brain: Effects of Experimental Diabetes

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Effect of chronic REM sleep deprivation on pituitary, hypothalamus and hippocampus PGE2 and PGD2 biosynthesis in the mouse

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Effect of REM sleep deprivation on immune function in rats

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