Age-related changes of the antigen-specific antibody formation in vitro and PHA-induced T-cell proliferation in individuals who met the health criteria of the senieur protocol

Admission criteria for immunogerontological studies in man: The senieur protocol

1984 • 754 citations

Impaired Lymphocyte Function in Aged Humans

1974 • 350 citations

Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans

1973 • 286 citations

The synergy between naive and memory T cells during activation

1991 • 247 citations

Decline in mitogen induced proliferation of lymphocytes with increasing age.

1987 • 192 citations

Age-related decline in the in vitro and in vivo syntheses of anti-tetanus toxoid antibody in humans.

1980 • 156 citations

Failure to respond to influenza vaccine in the aged: correlation with B-cell number and function.

1978 • 130 citations

Immunological studies of aging

1989 • 129 citations

Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified tac-positive T cells

1986 • 114 citations

Influenza and aging: Age-related changes and the effects of thymosin on the antibody response to influenza vaccine

1984 • 81 citations

Immune function in aged mice IV. Loss of T cell and B cell function in thymus‐dependent antibody responses

1978 • 80 citations

Measurement of antibody-producing capacity in man. I. The normal response to flagellin from Salmonella adelaide.

1969 • 75 citations

Interleukin-2 production and activity in aged humans

1985 • 73 citations

Lymphocyte proliferative response to PHA and anti-CD3/Ti monoclonal antibodies, T cell surface marker expression, and serum IL-2 receptor levels as biomarkers of age and health

1988 • 64 citations

Subpopulations of mononuclear cells in ageing: expansion of the null cell compartment and decrease in the number of T and B cells in human blood.

1985 • 63 citations

The role of T cell phenotypes in decreased lymphoproliferation of the elderly

1989 • 52 citations

Age-associated changes in proliferative and differentiative response of human B cells and production of T cell-derived factors regulating B cell functions

1987 • 41 citations

Defect of autologous mixed lymphocyte reaction and interleukin-2 in aged individuals

1985 • 38 citations

Age-related changes of the function of T cell subsets: Predominant defect of the proliferative response in CD8 positive T cell subset in aged persons

1987 • 36 citations

Influence of age on the immunological activity and capacity of the CBA mouse

1978 • 32 citations

Cytokine regulation of B-cell growth and differentiation

1989 • 28 citations

Enumeration of (auto)antibody producing cells in human using the “spot-ELISA”

1985 • 25 citations

Immunoglobulin class and subclass levels in the serum of CBA mice throughout life.

1977 • 20 citations

Enhancement of mitogen response and surface marker analysis of lymphocytes from yuong and old donors after preliminary incubation in vitro

1985 • 17 citations

Influence of ageing on antibody formation in vivo after immunisation with the primary T-cell dependent antigen Helix pomatia haemocyanin

1992 • 14 citations

Influence of age on cellular differentiation: A T cell model

1986 • 12 citations

The age-related decline in antibody response is transferred by old to young bone marrow transplantation

1986 • 2 citations