A Mitochondria-Targeted Nitroxide/Hemigramicidin S Conjugate Protects Mouse Embryonic Cells Against Gamma Irradiation

Mitochondrial control of cell death

2000 • 3,098 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Mechanisms of cytochrome c release from mitochondria

2006 • 1,208 citations

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

2005 • 1,169 citations

Cytochrome c release from mitochondria proceeds by a two-step process

2002 • 917 citations

Flow Cytometric Analysis of Respiratory Burst Activity in Phagocytes With Hydroethidine and 2′,7′-Dichlorofluorescin

1990 • 869 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology

2004 • 662 citations

Mitochondria as a Pharmacological Target

2002 • 542 citations

Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

1997 • 445 citations

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

1998 • 432 citations

Biologically active metal-independent superoxide dismutase mimics

1990 • 427 citations

Reactive Oxygen Species in Mitochondria-Mediated Cell Death

2007 • 421 citations

Factors underlying the cell growth-related bystander responses to alpha particles.

2000 • 346 citations

Cardiolipin: Setting the beat of apoptosis

2007 • 283 citations

Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca²⁺ is dependent on mitochondrial‐generated reactive oxygen species

1996 • 246 citations

Radioprotection by antioxidants.

2000 • 234 citations

Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, Tempol

1991 • 229 citations

Tempol, a stable free radical, is a novel murine radiation protector.

1992 • 212 citations

DNA double-strand break repair

1999 • 209 citations

Radiation-Induced Genomic Instability: Delayed Mutagenic and Cytogenetic Effects of X Rays and Alpha Particles

1997 • 199 citations

Radioprotection by Antioxidants^a

2000 • 189 citations

Early changes in intramitochondrial cardiolipin distribution during apoptosis.

2002 • 177 citations

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review

2006 • 173 citations

Persistent oxidative stress in chromosomally unstable cells.

2003 • 171 citations

Review: Proximity effects in the production of chromosome aberrations by ionizing radiation

1997 • 156 citations

Mitochondrial Targeting of Selective Electron Scavengers: Synthesis and Biological Analysis of Hemigramicidin−TEMPO Conjugates

2005 • 147 citations

Enzymatic Restriction of Mammalian Cell DNA: Evidence for Double-strand Breaks as Potentially Lethal Lesions

1985 • 146 citations

Ionizing Radiation and Chemotherapeutic Drugs Induce Apoptosis in Lymphocytes in the Absence of FAS or Fadd/Mort1 Signaling

2000 • 142 citations

Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state.

1997 • 126 citations

Interaction of peroxidized cardiolipin with rat‐heart mitochondrial membranes: Induction of permeability transition and cytochrome c release

2006 • 125 citations

Structural Requirements for Optimized Delivery, Inhibition of Oxidative Stress, and Antiapoptotic Activity of Targeted Nitroxides

2006 • 82 citations

Radiation, Radicals, and Images

2000 • 72 citations

CDC25B and p53 are independently implicated in radiation sensitivity for human esophageal cancers.

2000 • 66 citations

Reactive Species-Mediated Regulation of Cell Signaling and the Cell Cycle: The Role of MAPK

2005 • 61 citations

Nitroxides Tempol and Tempo Induce Divergent Signal Transduction Pathways in MDA-MB 231 Breast Cancer Cells

1998 • 55 citations

Overexpression of CDC25B overrides radiation-induced G2-M arrest and results in increased apoptosis in esophageal cancer cells.

2001 • 53 citations

Nitroxide tempo, a small molecule, induces apoptosis in prostate carcinoma cells and suppresses tumor growth in athymic mice

2005 • 52 citations

Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor

2005 • 52 citations

In vivo radioprotection and effects on blood pressure of the stable free radical nitroxides

1998 • 52 citations

Loss of G2/M arrest correlates with radiosensitization in two human sarcoma cell lines with mutant p53

2001 • 45 citations

Study of in vitro and in vivo effects of the piperidine nitroxide Tempol—a potential new therapeutic agent for gliomas

2003 • 43 citations

Two Reaction Sites of a Spin Label, TEMPOL (4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), with Hydroxyl Radical

2003 • 41 citations

Nitroxides as Radiation Protectors

2002 • 23 citations