Radioprotection by antioxidants.

Oxygen Poisoning and X-irradiation: A Mechanism in Common

1954 • 917 citations

Cysteine Protection against X Irradiation

1949 • 598 citations

In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate.

1976 • 457 citations

Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells

1999 • 436 citations

Antioxidant enzyme levels in cancer.

1997 • 396 citations

Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study

1995 • 380 citations

Rationale and strategies for chemoprevention of cancer in humans.

1987 • 366 citations

Role of Antioxidant Enzymes on Ionizing Radiation Resistance

1998 • 279 citations

Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor.

1988 • 265 citations

Induction of mitochondrial manganese superoxide dismutase by interleukin 1

1988 • 232 citations

Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms.

1986 • 183 citations

Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy

1998 • 179 citations

Modifying effect of vitamins C, E and beta-carotene against gamma-ray-induced DNA damage in mouse cells

1998 • 176 citations

Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD

1995 • 172 citations

In Vivo Radioprotection by Ocimum Flavonoids: Survival of Mice

1999 • 168 citations

Comparative antioxidant activities of propranolol, nifedipine, verapamil, and diltiazem against sarcolemmal membrane lipid peroxidation.

1990 • 164 citations

Risk biomarkers and current strategies for cancer chemoprevention

1996 • 162 citations

Radiation-induced long-lived radicals which cause mutation and transformation

1998 • 151 citations

Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase

1992 • 145 citations

New agents for cancer chemoprevention

1996 • 136 citations

Bacq and Alexander Award Lecture Chemical radioprotection: past, present and future prospects

1998 • 136 citations

Pharmacologic approaches to protection against radiation-induced lethality and other damage.

1997 • 122 citations

Advances in Radioprotection through the Use of Combined Agent Regimens

1990 • 121 citations

Protection of Liposomal Lipids against Radiation Induced Oxidative Damage

1979 • 118 citations

Protective Effects of Vitamins C and E Against γ-ray-induced Chromosomal Damage in Mouse

1993 • 118 citations

Superoxide dismutase amplifies organismal sensitivity to ionizing radiation

1989 • 116 citations

The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice

1989 • 116 citations

Clastogenic Factors in the Plasma of Chernobyl Accident Recovery Workers: Anticlastogenic Effect of Ginkgo biloba Extract

1995 • 111 citations

Copper- and zinc-containing superoxide dismutase and manganese-containing superoxide dismutase in human tissues and human malignant tumors.

1981 • 108 citations

A comparative study of radioprotection by Ocimum flavonoids and synthetic aminothiol protectors in the mouse.

1998 • 105 citations

Reduction of cancer risk with an oral supplement of selenium.

1997 • 104 citations

Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action

1995 • 99 citations

Role of superoxide dismutase in modification of radiation injury.

1987 • 99 citations

Thymus-like activities of sulphur derivatives on T-cell differentiation.

1977 • 93 citations

Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug Ethyol (WR-2721), protect DNA against fast neutroninduced strand breakage

1997 • 92 citations

Modifying effect of Vitamine C, E, and betacarotene against γ-ray-induced DNA damage in mouse cells

1998 • 85 citations

Inhibition of radiation carcinogenesis in mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.

1984 • 84 citations

Clastogenic factors in the plasma of children exposed at Chernobyl

1997 • 82 citations

Melatonin: possible mechanisms involved in its ‘radioprotective’ effect

1998 • 76 citations

Progress in clinical chemoprevention.

1997 • 76 citations

Modulation with cytokines of radiation injury: suggested mechanisms of action.

1997 • 75 citations

Radioprotection of Hematopoietic Tissues in Mice by Lipoic Acid

1992 • 73 citations

Radiation, Radicals, and Images

2000 • 72 citations

Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and oligoelements

1997 • 71 citations

Can WR-2721 be improved upon?

1988 • 63 citations

Change of glutathione peroxidase synthesis along with that of superoxide dismutase synthesis in mice spleens after low-dose X-ray irradiation

1998 • 61 citations

Effect of natural b -carotene supplementation in children exposed to radiation from the Chernobyl accident

1998 • 60 citations

Motor Activity and Screening for Neurotoxicity

1989 • 57 citations

Caffeine protects mice against whole-body lethal dose of gamma-irradiation

1999 • 53 citations

Radioprotection by antioxidant enzymes and enzyme mimetics

1988 • 50 citations

Behavioral toxicity of selected radioprotectors

1992 • 48 citations

Elevation of Extracellular Adenosine Induces Radioprotective Effects in Mice

1993 • 48 citations

The inhibition of radiation-induced mutagenesis by the combined effects of selenium and the aminothiol WR-1065

1996 • 46 citations

Protection of Normal Tissue from the Cytotoxic Effects of Chemotherapy and Radiation by Amifostine: Clinical Experiences

1995 • 46 citations

Dose and time relationships of the radioprotector WR-2721 on locomotor activity in mice

1987 • 44 citations

Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine

1988 • 43 citations

Morbidity and mortality reduction by supplemental vitamin A or beta-carotene in CBA mice given total-body gamma-radiation.

1984 • 38 citations

Hypotensive Mechanisms of Amifostine

1996 • 37 citations

Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278

1990 • 33 citations

Caffeine consumption is associated with decreased severe late toxicity after radiation to the pelvis

1994 • 33 citations

Radioprotection by caffeine pre- and post-treatment in the bone marrow chromosomes of mice given whole-body γ-irradiation

1992 • 32 citations

A novel interaction of diethyldithiocarbamate with the glutathione/glutathione peroxidase system

1986 • 31 citations

Essential Metalloelement Metabolism and Radiation Protection and Recovery

1992 • 28 citations

Protective effect of dipyridamole against lethality and lipid peroxidation in liver and spleen of the ddY mouse after whole-body irradiation

1996 • 28 citations

Long-term effects of radioprotector WR-2721 on locomotor activity and body weight of mice following exposure to ionizing radiation

1988 • 27 citations

Calcium antagonists protect mice against lethal doses of ionizing radiation

1992 • 26 citations

Selenite-Induced Variation in Glutathione Peroxidase Activity of Three Mammalian Cell Lines: No Effect on Radiation-Induced Cell Killing or DNA Strand Breakage

1989 • 25 citations

Radioprotection of mouse intestine by inhibitors of cyclic AMP phosphodiesterase

1979 • 25 citations

Radioprotective and hemodynamic effects of WR-2721 and cystamine in rats: time course studies.

1983 • 22 citations

Protection by WR-151327 against Late-Effect Damage from Fission-Spectrum Neutrons

1991 • 19 citations

Effects of administering tocopherol after irradiation on survival and proliferation of murine lymphocytes

1988 • 19 citations

Mammalian cell polyamine homeostasis is altered by the radioprotector WR1065

1998 • 17 citations

Tumor radiosensitization with concomitant vone marrow radioprotection: A study in mice using diethyldithiocarbamate (DDC) under oxygenated and hypoxic conditions

1985 • 17 citations

Membrane antiperoxidative activities of -propranolol, -propranolol and dimethyl quaternary propranolol (UM-272)

1992 • 16 citations

Repair mechanisms in mammalian cells

1974 • 11 citations

Bone marrow cell protection and modification of drug toxicity by combination of protectors

1988 • 10 citations

AMINOTHIOLS PROTECT ENDOTHELIAL CELL PROLIFERATION AGAINST INHIBITION BY LIPOPOLYSACCHARIDE

1998 • 9 citations

Modification of radiation-induced gastrointestinal and hematopoietic injury in mice by combinations of agents: effects of indomethacin and caffeine.

1997 • 9 citations

Calcium antagonist radioprotectors do not reduce radiotherapeutic efficacy in three human tumor xenografts.

1995 • 7 citations

Suppression of delayed-type hypersensitivity to oxazolone in whole-body-irradiated mice and protection by WR-2721.

1984 • 4 citations