Structural Requirements for Optimized Delivery, Inhibition of Oxidative Stress, and Antiapoptotic Activity of Targeted Nitroxides
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References (40)
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 • 3,867 citations
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
2005 • 2,499 citations
Production of large amounts of hydrogen peroxide by human tumor cells.
1991 • 2,465 citations
p-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure
1964 • 2,191 citations
Oxidative stress in neurodegeneration: cause or consequence?
2004 • 1,803 citations
Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane
2002 • 1,443 citations
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
2005 • 1,169 citations
Parkinson's Disease Brain Mitochondrial Complex I Has Oxidatively Damaged Subunits and Is Functionally Impaired and Misassembled
2006 • 703 citations
Targeting an antioxidant to mitochondria decreases cardiac ischemia‐reperfusion injury
2005 • 581 citations
Macroscopic models of aqueous solutions: biological and chemical applications
1993 • 520 citations
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
2001 • 507 citations
Targeting antioxidants to mitochondria: A new therapeutic direction
2005 • 397 citations
Reperfusion injury: Experimental evidence and clinical implications
1999 • 333 citations
Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide.
1992 • 322 citations
Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction.
1994 • 256 citations
Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation
1999 • 248 citations
A novel metal-free low molecular weight superoxide dismutase mimic.
1988 • 228 citations
Tempol, a stable free radical, is a novel murine radiation protector.
1992 • 212 citations
Oxidatively damaged proteins of heart mitochondrial electron transport complexes
2003 • 201 citations
Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: Role of mitochondrial superoxide
2005 • 196 citations
A Bax-Induced Pro-Oxidant State Is Critical for CytochromecRelease during Programmed Neuronal Death
2002 • 167 citations
Mitochondrial Targeting of Selective Electron Scavengers: Synthesis and Biological Analysis of Hemigramicidin−TEMPO Conjugates
2005 • 147 citations
Peroxynitrite and drug-dependent toxicity
2004 • 146 citations
Membrane-bound structure and alignment of the antimicrobial beta-sheet peptide gramicidin S derived from angular and distance constraints by solid state 19F-NMR.
2001 • 117 citations
Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3‐nitropropionic acid
2004 • 115 citations
Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion
1999 • 109 citations
Bax, Reactive Oxygen, and CytochromecRelease in Neuronal Apoptosis
2003 • 98 citations
Electrostatic versus Steric Effects in Peptidomimicry: Synthesis and Secondary Structure Analysis of Gramicidin S Analogues with (E)-Alkene Peptide Isosteres
2005 • 91 citations
Cerebroprotective effect of stable nitroxide radicals in closed head injury in the rat
1996 • 90 citations
Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases?
2002 • 81 citations
Prevention of Hyperoxia‐Induced Alterations in Synaptosomal Membrane‐Associated Proteins by N‐tert‐Butyl‐α‐Phenylnitrone and 4‐Hydroxy‐2,2,6,6‐Tetramethylpiperidin‐1‐oxyl (Tempol)
1996 • 74 citations
Radiation, Radicals, and Images
2000 • 72 citations
Kinetics of superoxide-induced exchange among nitroxide antioxidants and their oxidized and reduced forms
1999 • 67 citations
Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease
2005 • 63 citations
A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats.
1994 • 59 citations
Study of in vitro and in vivo effects of the piperidine nitroxide Tempol—a potential new therapeutic agent for gliomas
2003 • 43 citations
The Plasma Membrane Is the Site of Selective Phosphatidylserine Oxidation During Apoptosis: Role of Cytochromec
2004 • 41 citations
Trisubstituted (E)-Alkene Dipeptide Isosteres as β-Turn Promoters in the Gramicidin S Cyclodecapeptide Scaffold
2006 • 38 citations
Atomic Detail Peptide-Membrane Interactions: Molecular Dynamics Simulation of Gramicidin S in a DMPC Bilayer
2000 • 34 citations
Targeting Mitochondria Emerges as Therapeutic Strategy
2005 • 18 citations