Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

2006 • 2,860 citations

Intracellular amyloid-β in Alzheimer's disease

2007 • 1,796 citations

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

2007 • 1,795 citations

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

2001 • 1,543 citations

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

2001 • 1,469 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

2005 • 1,206 citations

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease

2005 • 1,147 citations

Intraneuronal Aβ42 Accumulation in Human Brain

2000 • 955 citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1999 • 918 citations

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

2004 • 760 citations

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1995 • 686 citations

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

2002 • 679 citations

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

1999 • 664 citations

Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

2001 • 581 citations

Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

2004 • 434 citations

Alzheimer disease models and human neuropathology: similarities and differences

2007 • 418 citations

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

2001 • 385 citations

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

2002 • 377 citations

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

2003 • 367 citations

Aβ localization in abnormal endosomes: association with earliest Aβ elevations in AD and Down syndrome

2004 • 346 citations

Synaptic slaughter in Alzheimer's disease

2003 • 340 citations

Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

2001 • 337 citations

Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease

2005 • 312 citations

β-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System

2006 • 300 citations

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

2001 • 271 citations

Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

2004 • 265 citations

Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice

2006 • 261 citations

Intraneuronal Aβ42 accumulation in Down syndrome brain

2002 • 251 citations

A Conformation‐ and Phosphorylation‐Dependent Antibody Recognizing the Paired Helical Filaments of Alzheimer's Disease

1997 • 247 citations

The Arctic Alzheimer mutation facilitates early intraneuronal Aβ aggregation and senile plaque formation in transgenic mice

2005 • 239 citations

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

2001 • 230 citations

Intracellular Mechanisms of Amyloid Accumulation and Pathogenesis in Alzheimer's Disease

2001 • 221 citations

p25/Cyclin-Dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid βIn Vivo

2006 • 202 citations

Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356

1996 • 144 citations

Apolipoprotein E and Low Density Lipoprotein Receptor-related Protein Facilitate Intraneuronal Aβ42 Accumulation in Amyloid Model Mice

2006 • 128 citations

AβPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576

2002 • 116 citations

Hippocampal alpha2a-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytes.

1998 • 104 citations

Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the β-amyloid peptide intracellularly in hippocampal and cortical neurons

2004 • 100 citations

Inter-laboratory comparison of neuropathological assessments of β-amyloid protein: a study of the BrainNet Europe consortium

2008 • 95 citations

Hippocampal ?2A-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytes

1998 • 91 citations

Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice

2003 • 82 citations

Intraneuronal amyloid β and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease

2006 • 60 citations

Review on the APP/PS1KI mouse model: intraneuronal Aβ accumulation triggers axonopathy, neuron loss and working memory impairment

2008 • 55 citations

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