Age, Hypertension and Hypercholesterolaemia Alter Endothelium‐Dependent Vascular Regulation

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.

1986 • 892 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

A specific inhibitor of nitric oxide formation from <scp>l</scp>‐arginine attenuates endothelium‐dependent relaxation

1989 • 862 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.

1990 • 803 citations

The Endothelium: Modulator of Cardiovascular Function

2020 • 543 citations

Role of endothelium in dilator responses of spontaneously hypertensive rat arteries.

1983 • 414 citations

Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats.

1987 • 404 citations

The loss of endothelium-dependent vascular relaxation in hypertension.

1986 • 372 citations

A clinical safety trial of stroma‐free hemoglobin

1978 • 361 citations

Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium.

1992 • 357 citations

Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.

1991 • 331 citations

Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta

1987 • 310 citations

Plasma endothelin levels in hypertension and chronic renal failure.

1990 • 302 citations

L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.

1990 • 278 citations

Activation of endothelial L-arginine pathway in resistance arteries. Effect of age and hypertension.

1990 • 254 citations

Prostaglandin H2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat.

1990 • 250 citations

Imbalance of Endothelium-derived Relaxing and Contracting Factors: A New Concept in Hypertension?

1990 • 243 citations

Effects of endothelin on the renal artery from spontaneously hypertensive and Wistar Kyoto rats

1988 • 241 citations

Age and hypertension promote endothelium-dependent contractions to acetylcholine in the aorta of the rat.

1989 • 219 citations

Endothelin-1-induced vasoconstriction in humans. Reversal by calcium channel blockade but not by nitrovasodilators or endothelium-derived relaxing factor.

1991 • 216 citations

A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: Comparison of levels in patients with essential hypertension and normotensive control subjects

1990 • 198 citations

Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension.

1987 • 196 citations

Endothelium-dependent and endothelium-independent vasodilation in resistance arteries from hypertensive rats.

1988 • 193 citations

Decreased Endothelium-dependent Relaxation in New Zealand Genetic Hypertensive Rats

1984 • 189 citations

Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells

1989 • 185 citations

Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery.

1988 • 185 citations

Endothelium-dependent responses in carotid and renal arteries of normotensive and hypertensive rats.

1988 • 157 citations

Endothelium-dependent and independent relaxation of aortic rings from hypertensive rats

1986 • 154 citations

Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle.

1990 • 152 citations

Atrial natriuretic factor prevents NaCl-sensitive hypertension in spontaneously hypertensive rats.

1990 • 123 citations

Endothelin in hypertensive resistance arteries. Intraluminal and extraluminal dysfunction.

1991 • 122 citations

Endothelium-Dependent Reactivity in Resistance Vessels

2015 • 112 citations

Indomethacin Improves the Impaired Endothelium-dependent Relaxations in Small Mesenteric Arteries of the Spontaneously Hypertensive Rat

1990 • 108 citations

Plasma concentrations of endothelin-1 in spontaneously hypertensive rats and DOCA-salt hypertensive rats

1990 • 107 citations

Characteristics of pressor response to endothelin in spontaneously hypertensive and Wistar-Kyoto rats.

1989 • 101 citations

Age-related decrease in endothelium-dependent dilator response to histamine in rat mesenteric artery

1986 • 97 citations

Impaired endothelium-dependent relaxations in rabbits subjected to aortic coarctation hypertension.

1987 • 82 citations

Effect of age on blood pressure and membrane-dependent vascular responses in the rat.

1987 • 81 citations

Aging differentially affects direct and indirect actions of endothelin‐1 in perfused mesenteric arteries of the rat

1990 • 79 citations

Endothelin-1

1989 • 79 citations

Reactivity of Aorta and Mesenteric Microvessels to Drugs in Spontaneously Hypertensive Rats: Role of the Endothelium

1987 • 76 citations

Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta.

1991 • 69 citations

Effect of increasing age on the endothelium-mediated relaxation of rat blood vessels in vitro.

1987 • 68 citations

Endothelium-derived relaxing and contracting factors: potential role in coronary artery disease

1989 • 59 citations

Blood platelets in human essential hypertension

1986 • 55 citations

Decreased responsiveness of the aortae of hypertensive rats to acetylcholine, histamine and noradrenaline

1987 • 46 citations

Hyperreactivity of platelets from spontaneously hypertensive rats. Role of external magnesium.

1986 • 45 citations

Responses to noradrenaline in human subcutaneous resistance arteries are mediated by both α₁‐ and α₂‐adrenoceptors

1990 • 44 citations

Detection and characterization of endothelin-1-like immunoreactivity in rat plasma

1989 • 41 citations

Increased vasodilator responses to acetylcholine in psychosocial hypertensive mice.

1987 • 38 citations

Platelets in Human Essential Hypertension: in vitro Hyperreactivity to Thrombin

1986 • 32 citations

Dietary effect on platelet aggregation in men with and without a family history of essential hypertension.

1984 • 26 citations

Endothelium-mediated spontaneous response in aortic rings of deoxycorticosterone acetate-hypertensive rats.

1989 • 26 citations

5-Hydroxytryptamine kinetics and activation of blood platelets in patients with essential hypertension.

1990 • 21 citations

Platelet serotonin content and uptake in spontaneously hypertensive rats

1985 • 17 citations

Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo

1988 • 15 citations

Mechanisms of Altered Endothelium-Dependent Responses in Hypertensive Blood Vessels

1988 • 14 citations

Endotheiium-dependent and independent relaxation effects on aorta preparations of renal hypertensive rats

1984 • 14 citations

Vascular Reactivity in Neonatal Spontaneously Hypertensive Rats1

2015 • 13 citations

Age and the Platelet Serotonin Vasoconstrictor Axis in Essential Hypertension

1988 • 10 citations

Age and the Platelet Serotonin Vasoconstrictor Axis in Essential Hypertension

1988 • 7 citations

Endothelium-dependent relaxation effects in aorta from hypertensive rats

1984 • 5 citations

Necessity of divalent cations for recovery from carbachol‐induced nicotinic acetylcholine receptor inactivation at snake twitch fibre endplates

1993 • 3 citations

Introduction

2015 • 3 citations