On the potential significance of the enzymatic activity of mite allergens to immunogenicity. Clues to structure and function revealed by molecular characterization

Normal alveolar epithelial lining fluid contains high levels of glutathione

1987 • 795 citations

Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases.

1988 • 469 citations

Bronchial lymphoid tissue. I. Morphologic characteristics.

1973 • 344 citations

A major house dust mite allergen disrupts the immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases.

1995 • 279 citations

Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp)

1989 • 263 citations

ALLERGIC REACTIONS OF THE LUNGS TO ENZYMES OF BACILLUS SUBTILIS

1969 • 258 citations

Is the Bronchus-associated Lymphoid Tissue (BALT) an Integral Structure of the Lung in Normal Mammals, Including Humans?

1990 • 240 citations

Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1.

1995 • 233 citations

Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction

1990 • 215 citations

Sequence analysis of cDNA coding for a major house dust mite allergen, Der f I

1991 • 215 citations

Are bacterial proteinases pathogenic factors?

1995 • 205 citations

Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid

1992 • 180 citations

Conformational stability of B cell epitopes on group I and group II Dermatophagoides spp. allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies.

1990 • 179 citations

Bronchial lymphoid tissue. II. Functional characterisitics.

1973 • 172 citations

Der p I, a major allergen of the house dust mite, proteolytically cleaves the low‐affinity receptor for human IgE (CD23)

1995 • 164 citations

The fate of desmosomes in trypsinized tissue

1968 • 158 citations

Isolation of cDNA Coding for the Major Mite Allergen <i>Der </i><i>p</i> II by IgE Plaque Immunoassay

1990 • 151 citations

Changes in T-Lymphocyte Subpopulations after Antigenic Bronchial Provocation in Asthmatics

1984 • 139 citations

The group III allergen from the house dust mite Dermatophagoides pteronyssinus is a trypsin-like enzyme.

1992 • 136 citations

Gut‐ and bronchus‐associated lymphoid tissue

1984 • 128 citations

Purification and partial characterization of two major allergens from the house dust mite

1985 • 116 citations

EXPECTATIONS

1983 • 115 citations

Allergens from Dermatophagoides mites with chymotryptic activity

1993 • 110 citations

The isolation and characterization of a novel collagenolytic serine protease allergen (Der p 9) from the dust mite

1996 • 108 citations

House dust mite-derived amylase: Allergenicity and physicochemical characterization

1991 • 95 citations

Comparative modelling of major house dust mite allergen Der p I: structure validation using an extended environmental amino acid propensity table

1994 • 89 citations

Overlapping T-cell epitopes in the group I allergen of species restricted by HLA-DP and HLA-DR class II molecules

1994 • 89 citations

Cloning and sequencing of a cDNA expressing a recombinant house dust mite protein that binds human IgE and corresponds to an important low molecular weight allergen.

1989 • 88 citations

What Makes an Allergen an Allergen

1978 • 86 citations

Permeability of the Bronchial Mucosa to^99mTc-DTPA in Asthma

1989 • 85 citations

Cloning and characterization of a major allergen of the house dust mite, Dermatophagoides pteronyssinus, homologous with glutathione S-transferase

1994 • 77 citations

Study of Bronchus-associated Lymphoid Tissue in Patients with Diffuse Panbronchiolitis

1992 • 77 citations

Bronchus-associated lymphoid tissue (BALT) in the lungs of children who had died from sudden infant death syndrome and other causes.

1995 • 76 citations

cDNA encoding the major mite allergen Der f II

1991 • 68 citations

Pathogenic potentials of bacterial proteases

1989 • 66 citations

Cloning and sequencing of the Dermatophagoides pteronyssinus group III allergen, Der p III

1994 • 65 citations

Sequence Polymorphisms of cDNA Clones Encoding the Mite Allergen <i>Der </i><i>p</i> I

1993 • 65 citations

Size heterogeneity, phosphorylation and transmembrane organisation of desmosomal glycoproteins 2 and 3 (desmocollins) in MDCK cells

1990 • 64 citations

Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure

1979 • 60 citations

Molecular cloning of a house dust mite allergen with common antibody binding specificities with multiple components in mite extracts

1993 • 60 citations

Cloning and Expression of cDNA Coding for a New Allergen from the House Dust Mite, Dermatophagoides farinae: Homology with Human Heat Shock Cognate Proteins in the Heat Shock Protein 70 Family1

1994 • 55 citations

Molecular Characterisation of Group I Allergen <i>Eur </i><i>m</i> I from House Dust Mite <i>Euroglyphus maynei</i>

1992 • 53 citations

Activation of Kallikrein-Kinin System in Human Plasma with Purified Serine Protease from <i>Dermatophagoides farina</i><i>e</i>

1990 • 52 citations

The Airway Epithelium

1995 • 50 citations

Effect of microbial and mite proteases on low and high molecular weight kininogens. Generation of kinin and inactivation of thiol protease inhibitory activity.

1993 • 49 citations

A freeze-fracture study of human bronchial epithelium in normal, bronchitic and asthmatic subjects.

1988 • 43 citations

In vitro modulation of the eosinophil‐dependent enhancement of the permeability of the bronchial mucosa

1991 • 34 citations

Low incidence of bronchus-associated lymphoid tissue (BALT) in chronically inflamed human lungs

1992 • 33 citations

cDNA cloning and expression of a novel human desmocollin

1994 • 30 citations

Infectious asthma: a reemerging clinical entity?

1995 • 26 citations

Viral "bronchitis" in childhood: relationship to asthma and obstructive lung disease.

1988 • 18 citations

Stimulated eosinophils and proteinases augment the transepithelial flux of albumin in bovine bronchial mucosa

1993 • 14 citations

Expression cloning of a dust mite cysteine proteinase, Der p1, a major allergen associated with asthma and hypersensitivity reactions

1994 • 11 citations

Macrophage and Dendritic Cell Populations in the Respiratory Tract

1995 • 6 citations