The Airway Epithelium

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis

1977 • 1,317 citations

Damage of the Airway Epithelium and Bronchial Reactivity in Patients with Asthma

1985 • 1,315 citations

The Lung: Scientific Foundations

1991 • 1,181 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSA

1960 • 1,014 citations

Bronchial Biopsies in Asthma: An Ultrastructural, Quantitative Study and Correlation with Hyperreactivity

1989 • 973 citations

Molecular architecture of basement membranes

1990 • 937 citations

Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization

1993 • 825 citations

Normal alveolar epithelial lining fluid contains high levels of glutathione

1987 • 795 citations

The Structure of Large and Small Airways in Nonfatal and Fatal Asthma

1993 • 737 citations

Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.

1987 • 699 citations

Albumin—An important extracellular antioxidant?

1988 • 643 citations

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

1986 • 634 citations

Transformation of alveolar Type 2 cells to Type 1 cells following exposure to NO2

1975 • 577 citations

HEALTH EFFECTS OF OZONE A Critical Review

1989 • 574 citations

Pulmonary Strategies of Antioxidant Defense

1989 • 551 citations

Primary structures of three human neutrophil defensins.

1985 • 529 citations

IDENTIFICATION BY IMMUNOFLUORESCENCE OF EOSINOPHIL GRANULE MAJOR BASIC PROTEIN IN LUNG TISSUES OF PATIENTS WITH BRONCHIAL ASTHMA

1982 • 522 citations

Membrane ultrastructure at mammalian intercellular junctions

1973 • 516 citations

Monocyte-chemotactic activity of defensins from human neutrophils.

1989 • 486 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases.

1988 • 469 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

The Cells of the Pulmonary Airways^1,2

1977 • 460 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

Animal Models of Emphysema^1–3

1986 • 439 citations

Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium.

1980 • 434 citations

A Text-book of Practical Organic Chemistry Including Qualitative Organic Analysis.

1956 • 424 citations

Toxicity of Eosinophil Cationic Proteins for Guinea Pig Tracheal EpitheliumIn Vitro

1989 • 421 citations

Bleomycin-induced strand-scission of DNA. Mechanism of deoxyribose cleavage.

1981 • 415 citations

Autoxidation kinetics of aqueous nitric oxide

1993 • 412 citations

Chlorination of endogenous amines by isolated neutrophils. Ammonia-dependent bactericidal, cytotoxic, and cytolytic activities of the chloramines.

1984 • 397 citations

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

1984 • 392 citations

Modulation of Airway Epithelial Cell Ciliary Beat Frequency by Nitric Oxide

1993 • 373 citations

Damage to Schistosomula of Schistosoma Mansoni Induced Directly by Eosinophil Major Basic Protein

1979 • 368 citations

Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2

1993 • 338 citations

Ozone-induced Airway Inflammation in Human Subjects as Determined by Airway Lavage and Biopsy

1993 • 333 citations

Respiratory Defense Mechanisms.

1978 • 330 citations

Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma.

1981 • 314 citations

Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates.

1991 • 310 citations

Effects of Human Neutrophil Elastase and Pseudomonas aeruginosa Proteinases on Human Respiratory Epithelium

1991 • 301 citations

Inhalation of Nitric Oxide Modulates Adult Human Bronchial Tone

1993 • 296 citations

Evidence for energy-dependent accumulation of paraquat into rat lung

1974 • 294 citations

Renewal of the terminal bronchiolar epithelium in the rat following exposure to NO2 or O3.

1976 • 289 citations

PULMONARY DISEASE DUE TO INHALATION OF DERIVATIVES OF BACILLUS SUBTILIS CONTAINING PROTEOLYTIC ENZYME

1969 • 278 citations

Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury.

1985 • 268 citations

Interleukin-8 gene expression in human bronchial epithelial cells.

1991 • 260 citations

Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation

1987 • 257 citations

In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes

1986 • 257 citations

DNA Strand Breakage in Human Leukocytes Exposed to a Tumor Promoter, Phorbol Myristate Acetate

1982 • 255 citations

Nitric Oxide Synthesis Inhibitors Induce Airway Hyperresponsiveness in the Guinea PigIn VivoandIn Vitro: Role of the Epithelium

1993 • 254 citations

The Shedding of the Mucosa of the Bronchial Tree in Asthma

1962 • 252 citations

Identification of an isozymic form of acetyl-CoA carboxylase.

1990 • 250 citations

Drug Metabolism and Drug Toxicity

1985 • 249 citations

Biochemical and metabolic changes in the lung with oxygen, ozone, and nitrogen dioxide toxicity.

1978 • 247 citations

Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors.

1977 • 246 citations

MICROBIOLOGY OF LUNG INFECTIONS IN CYSTIC FIBROSIS PATIENTS

1982 • 234 citations

Stimulation of basophil and rat mast cell histamine release by eosinophil granule-derived cationic proteins.

1984 • 227 citations

Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2

1991 • 227 citations

Structure, function, and control of neutrophil proteinases

1988 • 226 citations

Regeneration of hamster tracheal epithelium after mechanical injury

1982 • 225 citations

Early Response of Lungs to Low Levels of Nitrogen Dioxide

1972 • 216 citations

Airway Hyperresponsiveness, Increased Intracellular Spaces of Bronchial Epithelium, and Increased Infiltration of Eosinophils and Lymphocytes in Bronchial Mucosa in Asthma

1992 • 211 citations

Defensin-rich dense granules of human neutrophils

1987 • 209 citations

Effect of Nitrogen Dioxide on Synthesis of Inflammatory Cytokines Expressed by Human Bronchial Epithelial Cells In Vitro

1993 • 205 citations

Human Eosinophil Major Basic Protein Causes Hyperreactivity of Respiratory Smooth Muscle: Role of the Epithelium

1988 • 199 citations

Granulocyte Neutral Proteases and Pseudomonas Elastase as Possible Causes of Airway Damage in Patients with Cystic Fibrosis

1984 • 196 citations

IDENTIFICATION OF A MAJOR BASIC PROTEIN IN GUINEA PIG EOSINOPHIL GRANULES

1973 • 196 citations

Ultrastructure of the Nonciliated Bronchiolar Epithelial (Clara) Cell of Mammalian Lung. III. A Study of Man with Comparison of 15 Mammalian Species

1980 • 196 citations

Poly(ADP-ribose) polymerase inhibitors preserve oxidized nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis

1983 • 195 citations

Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.

1990 • 195 citations

Constitutive expression of a 92-kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines.

1991 • 194 citations

Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family.

1989 • 190 citations

Matrix metalloproteinases. A review.

1990 • 187 citations

Reduction of ciliary beat frequency in vitro by sputum from patients with bronchiectasis: a serine proteinase effect.

1984 • 185 citations

Air Pollution, the Automobile, and Public Health

1989 • 185 citations

Experimental paraquat poisoning: A histo‐logical and electron‐optical study of the changes in the lung

1971 • 177 citations

Cytokines and pulmonary fibrosis.

1993 • 172 citations

Distribution of Integrin Cell Adhesion Receptors in Normal and Malignant Lung Tissue

1992 • 163 citations

Direct Cytotoxicity of Polymorphonuclear Leukocyte Granule Proteins to Human Lung-derived Cells and Endothelial Cells

1990 • 162 citations

Defensin-rich dense granules of human neutrophils

1987 • 162 citations

The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects.

1992 • 157 citations

Acute respiratory bronchiolitis: an ultrastructural and autoradiographic study of epithelial cell injury and renewal in rhesus monkeys exposed to ozone.

1980 • 156 citations

Airway hyperresponsiveness and changes in cell counts in bronchoalveolar lavage after ozone exposure in dogs.

1984 • 155 citations

Promotion of Eosinophil Survival by Human Bronchial Epithelial Cells and its Modulation by Steroids

1991 • 152 citations

Eosinophils Preferentially Use Bromide to Generate Halogenating Agents

1989 • 148 citations

Morphologic features of airway surface epithelial cells and glands.

1983 • 147 citations

Immune modulation of metalloproteinase production in human macrophages. Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon-gamma.

1990 • 146 citations

Interactions of granulocytes with the lungs.

1984 • 146 citations

Comparison of Nonciliated Tracheal Epithelial Cells in Six Mammalian Species: Ultrastructure and Population Densities

1983 • 145 citations

A Contiguous Network of Dendritic Antigen-Presenting Cells within the Respiratory Epithelium

1990 • 144 citations

Oxidative damage to fibronectin

1991 • 139 citations

The group III allergen from the house dust mite Dermatophagoides pteronyssinus is a trypsin-like enzyme.

1992 • 136 citations

Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases.

1989 • 135 citations

Eosinophil-mediated mammalian tumor cell cytotoxicity: role of the peroxidase system.

1980 • 135 citations

Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity

1986 • 133 citations

Acidic precursor revealed in human eosinophil granule major basic protein cDNA.

1988 • 133 citations

Epithelial cell volume modulation and regulation

1982 • 132 citations

Myeloperoxidase-catalyzed incorporation of amines into proteins: role of hypochlorous acid and dichloramines

1982 • 132 citations

Thiocyanate is the major substrate for eosinophil peroxidase in physiologic fluids. Implications for cytotoxicity.

1991 • 129 citations

Alteration of superoxide dismutase activity in tracheal epithelial cells by asbestos and inhibition of cytotoxicity by antioxidants.

1986 • 128 citations

Control of the beat cycle of respiratory tract cilia by Ca2+ and cAMP

1992 • 127 citations

Effect of Pseudomonas aeruginosa rhamnolipids on mucociliary transport and ciliary beating

1992 • 127 citations

Purification and some properties of myeloperoxidase and eosinophil peroxidase from human blood

1983 • 126 citations

Plasma exudation and asthma

1988 • 125 citations

Regulation of antigen-presenting cell function(s) in lung and airway tissues

1993 • 124 citations

[44] Leukocyte Elastase

1981 • 124 citations

The effect of cigarette smoke on the permeability of guinea pig airways.

1980 • 124 citations

Some properties of human eosinophil peroxidase, a comparison with other peroxidases

1984 • 124 citations

Animal models of emphysema

2019 • 122 citations

Regeneration of hamster tracheal epithelium after mechanical injury

1983 • 122 citations

The role of calcium in cell injury. A review.

1980 • 121 citations

Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D₁ cells

1986 • 120 citations

Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells.

1992 • 116 citations

Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein.

1988 • 115 citations

Cells of the lung: biology and clinical implications.

1983 • 112 citations

Morphological integrity of the bronchial epithelium in mild asthma.

1990 • 112 citations

The bronchial epithelium as a target for inflammatory attack in asthma

1992 • 110 citations

Epithelium-derived Relaxing Factor(s) and Bronchial Reactivity

1988 • 105 citations

Mechanisms of action of Pseudomonas aeruginosa pyocyanin on human ciliary beat in vitro

1993 • 105 citations

Effects of chemical mediators of anaphylaxis on ciliary function

1983 • 104 citations

Ambient nitrogen dioxide concentrations increase bronchial responsiveness in subjects with mild asthma

1988 • 104 citations

Monocyte-Macrophage Differentiation Induced by Human Upper Airway Epithelial Cells

1991 • 102 citations

Effect of human leukocyte enzymes on tracheal mucosa and its mucociliary activity.

1979 • 102 citations

Injurious Effect of the Eosinophil Peroxide-Hydrogen Peroxide-Halide System and Major Basic Protein on Human Nasal EpitheliumIn Vitro

1989 • 102 citations

[42] Cathepsin G

1981 • 101 citations

Pathology of occupational lung disease

1988 • 99 citations

House dust mite-derived amylase: Allergenicity and physicochemical characterization

1991 • 95 citations

Pathogenesis of the Pseudomonas Lung Lesion in Cystic Fibrosis

1989 • 90 citations

Proteolytic Enzymes, their Inhibitors and Lung Diseases

1983 • 90 citations

Gelatinase (type iv collagenase) immunolocalization in cells and tissues: Use of an antiserum to rabbit bone gelatinase that identifies high and low M r forms

1989 • 87 citations

Pathology of Occupational Lung Disease

1989 • 82 citations

The Role of Basal Cells in Adhesion of Columnar Epithelium to Airway Basement Membrane

1988 • 82 citations

Human eosinophil peroxidase: a novel isolation procedure, spectral properties and chlorinating activity

1981 • 82 citations

The Role of Basal Cells in Attachment of Columnar Cells to the Basal Lamina of the Trachea

1989 • 81 citations

Putative Role of Neutrophil Elastase in the Pathogenesis of Emphysema^a

1991 • 80 citations

Regeneration of hamster tracheal epithelium after mechanical injury

1982 • 80 citations

Regeneration of hamster tracheal epithelium after mechanical injury

1982 • 80 citations

Cell Adhesion Molecules and the Bronchial Epithelium

1993 • 78 citations

Faecally Derived Hydrolytic Enzymes from <i>Dermatophagoides pteronyssinus</i>: Physicochemical Characterisation of Potential Allergens

1991 • 78 citations

Lesions in respiratory bronchioles and conducting airways of monkeys exposed to ambient levels of ozone

1977 • 74 citations

Desmosomes, Cell Adhesion Molecules and the Adhesive Properties of Cells in Tissues

1986 • 69 citations

Pulmonary Antioxidant Defense Mechanisms

1985 • 68 citations

Effect of cyclic AMP on ciliary activity of human respiratory epithelium

1991 • 66 citations

SRS‐A leukotrienes decrease the activity of human respiratory cilia

1987 • 65 citations

Alveolar type 1 cell response to exposure to 0.5 PPM O3 for short periods

1974 • 63 citations

Effects of NO2 on the lungs of aging rats

1977 • 62 citations

Ciliary responsiveness in allergic and nonallergic airways

1986 • 59 citations

Modulation by the epithelium of the extent of bronchial narrowing produced by substances perfused through the lumen

1991 • 59 citations

Effect of salmeterol on human nasal epithelial cell ciliary beating: inhibition of the ciliotoxin, pyocyanin

1994 • 57 citations

Bovine bronchial epithelial cells metabolize L-arginine to L-citrulline: Possible role of nitric oxide synthase

1993 • 55 citations

Neutral Proteinases from Human Inflammatory Cells: A Critical Review of Their Role in Extracellular Matrix Degradation

1983 • 55 citations

The Response of the Lung to Foreign Compounds that Produce Free Radicals

1986 • 53 citations

Effects of Continuous Exposure of 0.8 PPM NO₂on Respiration of Rats

1966 • 53 citations

Occupational asthma after inhalation of dust of the proteolytic enzyme, papain.

1975 • 52 citations

Environmental pollution and human health

1994 • 51 citations

Effects of NO2 on the lungs of aging rats

1977 • 49 citations

Epidemiology of asthma

1993 • 48 citations

The experimental pathology of oxidant and air pollutant inhalation.

1980 • 47 citations

Enhancement of urokinase-induced plasminogen activation by the cationic protein of human eosinophil granulocytes

1979 • 47 citations

Inhibitory effects of BAY u3405 on prostanoid‐induced contractions in human isolated bronchial and pulmonary arterial muscle preparations

1991 • 46 citations

Junctional Adhesion Mechanisms in Airway Basal Cells

1990 • 46 citations

Deleterious effects of purulent sputum sol on human ciliary function in vitro: at least two factors identified.

1987 • 46 citations

Effect of nondialyzable solids concentration and viscoelasticity on ciliary transport of tracheal mucus.

1977 • 46 citations

Lung Fibroblasts Produce Growth Stimulatory Activity for Bronchial Epithelial Cells

1990 • 45 citations

Elastases and Emphysema

2015 • 44 citations

Morphologic and Ultrastructural Changes in the Lungs of Animals During Acute Exposure to Ozone

1974 • 43 citations

A freeze-fracture study of human bronchial epithelium in normal, bronchitic and asthmatic subjects.

1988 • 43 citations

Effects of Nitrogen Dioxide on Cell Renewal in the Rat Lung

1971 • 43 citations

Global Warming

1989 • 41 citations

A textbook of practical organic chemistry including qualitative organic analysis

1956 • 41 citations

Different Susceptibility of Elastase Inhibitors to Inactivation by Proteinases fromStaphylococcus aureusandPseudomonas aeruginosa

1991 • 40 citations

PULMONARY BIOCHEMICAL ALTERATIONS RESULTING FROM OZONE EXPOSURE<xref ref-type="fn" rid="fn1"><sup>*</sup></xref>

1976 • 39 citations

Acute effects of ozone on cat lungs. II. Structural.

1974 • 37 citations

Acute IMO₂ Effects on Penetration and Transport of Horseradish Peroxidase in Hamster Respiratory Epithelium

1983 • 37 citations

Health Effects of Air Pollution

1958 • 37 citations

Sodium and calcium regulation and the role of the cytoskeleton in the pathogenesis of disease: a review and hypothesis.

1981 • 35 citations

In vitro modulation of the eosinophil‐dependent enhancement of the permeability of the bronchial mucosa

1991 • 34 citations

Responsiveness of human isolated bronchial segments and its relationship to epithelial loss.

1993 • 31 citations

Defensins Reduce the Barrier Integrity of a Cultured Epithelial Monolayer without Cytotoxicity

1993 • 31 citations

SO2-induced bronchopathy in the rat: abnormal permeability of the bronchial epithelium in vivo and in vitro after anatomic recovery.

1980 • 27 citations

Is neutrophil elastase associated with elastic tissue in emphysema?

1988 • 25 citations

Beryllium disease

1988 • 22 citations

Cytologic changes in dogs lungs induced by chronic exposure to ozone.

1973 • 22 citations

Evidence that Pseudomonas aeruginosa elastase does not inactivate the bronchial inhibitor in the presence of leukocyte elastase. Studies with cystic fibrosis sputum and with pure proteins.

1985 • 21 citations

Ambient NOx concentrations in the U.K. 1976–1984—a summary

1988 • 20 citations

In vitro effect of beclomethasone dipropionate and flunisolide on the mobility of human nasal cilia

1987 • 20 citations

Effects of sulfur dioxide on pore populations of canine tracheal epithelium

1986 • 19 citations

Effects of nitrogen dioxide and ozone on monkey lung ultrastructure

1974 • 18 citations

Identification and Characterization of Novel Airway Epithelial Integrins

1993 • 17 citations

Resistance of Human Tracheal Epithelial Cells to Killing by Neutrophils, Neutrophil Elastase, and Pseudomonas Elastase

1993 • 17 citations

Ciliated cell differentiation in regenerating rat tracheal epithelium

1984 • 17 citations

Factors Affecting Ciliary Beat Frequency in the Intrapulmonary Airways of Rats

1975 • 16 citations

Leukotriene C₄ decreases the activity of respiratory cilia in vitro

1990 • 16 citations

Aspartic Proteinases in Normal Lung and Interstitial Pulmonary Diseases

1993 • 16 citations

Stimulated eosinophils and proteinases augment the transepithelial flux of albumin in bovine bronchial mucosa

1993 • 14 citations

Regeneration of Rat Tracheal Epithelium after Mechanical Injury

2015 • 13 citations

Biochemical and Cellular Interrelationships in the Development of Ozone-Induced Pulmonary Fibrosis

1988 • 12 citations

Regional Difference in Airway Epithelial Response to Neutrophil Elastase: Tracheal Secretory Cells Discharge and Recover in Hamsters That Develop Bronchial Secretory-Cell Metaplasia

1989 • 12 citations

Comparative Morphologic Features of Bronchiolar Epithelial Cells

2015 • 11 citations

A comparison of the effects of polyarginine and stimulated eosinophils on the responsiveness of the bovine isovolumic bronchial segment preparation

1993 • 9 citations

Cathepsin D from Human Leukocytes. Purification by Affinity Chromatography and Properties of the Enzyme

1988 • 9 citations

Effects of Instillation of Fly Ash in the Lung: Physicochemical Properties and Immune Responses

1989 • 7 citations

653 Expression of α 1-6 integrin cell-surface receptors in normal human bronchial biopsies (HBB) and cultured bronchial epithelial cells (HBE)

1991 • 6 citations

660 Eosinophil major basic protein (MBP) upregulates intercellular adhesion molecule-1 (ICAM-1) expression on human nasal epithelial cells (HNE)

1991 • 5 citations

Airway Epithelial Cells in the Pathophysiology of Asthma

1991 • 4 citations

Channels and vehicles of communication: The asbestos awareness campaign

1993 • 4 citations

659 Expression of intercellular adhesion molecule-1 (ICAM-1) on human nasal epithelial cells (HNE)

1991 • 3 citations