Determinants of F2-isoprostane biosynthesis and inhibition in man

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 8,631 citations

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

2000 • 8,612 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

1998 • 5,229 citations

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

1999 • 3,818 citations

Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

2000 • 3,760 citations

Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults

1999 • 3,707 citations

Helicobacter pyloriInfection

2002 • 2,932 citations

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 2,615 citations

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

1993 • 2,363 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

1998 • 2,047 citations

Homocysteine and Atherothrombosis

1998 • 2,021 citations

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo¹

1997 • 1,993 citations

Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells

2000 • 1,945 citations

Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients

2000 • 1,945 citations

Atherosclerosis: Basic Mechanisms

1995 • 1,697 citations

Platelets in atherothrombosis

2002 • 1,533 citations

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial

2002 • 1,394 citations

Increase in Circulating Products of Lipid Peroxidation (F₂-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage

1995 • 1,343 citations

Obesity and Systemic Oxidative Stress

2003 • 1,301 citations

Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea

1993 • 1,142 citations

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: a randomised placebo-controlled trial

2002 • 1,028 citations

Overweight, Obesity, and Health Risk

2000 • 962 citations

Widespread Coronary Inflammation in Unstable Angina

2002 • 911 citations

Body Mass Index and Mortality in a Prospective Cohort of US Adults

2000 • 831 citations

In Vivo Formation of 8-Iso-Prostaglandin F _2α and Platelet Activation in Diabetes Mellitus

1999 • 753 citations

Statins do more than just lower cholesterol

1996 • 714 citations

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor- , in Vivo

1997 • 677 citations

Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis

2001 • 671 citations

Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers

1996 • 621 citations

Thromboxane Biosynthesis and Platelet Function in Type II Diabetes Mellitus

1990 • 600 citations

Cellular Antioxidant Effects of Atorvastatin In Vitro and In Vivo

2002 • 590 citations

Platelet Activation in Obese Women

2002 • 536 citations

Associations of C-Reactive Protein With Measures of Obesity, Insulin Resistance, and Subclinical Atherosclerosis in Healthy, Middle-Aged Women

1999 • 535 citations

Endothelial Function and Oxidative Stress in Renovascular Hypertension

2002 • 533 citations

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

1998 • 509 citations

Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease

1997 • 461 citations

Role of Oxidant Stress in Endothelial Dysfunction Produced by Experimental Hyperhomocyst(e)inemia in Humans

1999 • 430 citations

Plasma 8‐epi‐PGF_2α levels are elevated in individuals with non‐insulin dependent diabetes mellitus

1995 • 394 citations

Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression

2003 • 384 citations

Oxidized Lipoproteins Degrade the Endothelial Surface Layer

2000 • 378 citations

Role of Angiotensin and Oxidative Stress in Essential Hypertension

1999 • 357 citations

In Vivo Formation of 8-Epi-Prostaglandin F _2α Is Increased in Hypercholesterolemia

1997 • 356 citations

Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man.

1995 • 340 citations

Impact of Infectious Burden on Extent and Long-Term Prognosis of Atherosclerosis

2002 • 338 citations

Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis

2002 • 308 citations

Peroxisome Proliferators Enhance Cyclooxygenase-2 Expression in Epithelial Cells

1999 • 298 citations

Increased Formation of Distinct F ₂ Isoprostanes in Hypercholesterolemia

1998 • 276 citations

Reduced Plasma Peroxyl Radical Trapping Capacity and Increased Susceptibility of LDL to Oxidation In Poorly Controlled IDDM

1994 • 272 citations

Increased Oxidative Stress in Experimental Renovascular Hypertension

2001 • 271 citations

Inhibition of Thromboxane Biosynthesis and Platelet Function by Simvastatin in Type IIa Hypercholesterolemia

1995 • 264 citations

Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide1

2002 • 257 citations

Diabetes Mellitus, Hypercholesterolemia, and Hypertension but Not Vascular Disease Per Se Are Associated With Persistent Platelet Activation In Vivo

1997 • 218 citations

Association Between Enhanced Soluble CD40L and Prothrombotic State in Hypercholesterolemia

2002 • 215 citations

The F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist

1992 • 214 citations

Increased Oxidative Stress and Platelet Activation in Patients With Hypertension and Renovascular Disease

2002 • 207 citations

Local Amplification of Platelet Function by 8-Epi Prostaglandin F2α Is Not Mediated by Thromboxane Receptor Isoforms

1996 • 205 citations

The isoprostanes in biology and medicine

2001 • 190 citations

Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation

2002 • 183 citations

Reduced susceptibility of low density lipoprotein (LDL) to lipid peroxidation after fluvastatin therapy is associated with the hypocholesterolemic effect of the drug and its binding to the LDL

1997 • 176 citations

Increased thromboxane biosynthesis in type IIa hypercholesterolemia.

1992 • 168 citations

Platelet‐derived CXC chemokines: old players in new games

2000 • 165 citations

Cell-cell interactions: leukocyte-endothelial interactions

2003 • 157 citations

Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism.

1993 • 157 citations

Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in plasma of smokers.

2002 • 139 citations

Enhanced Lipid Peroxidation and Platelet Activation in the Early Phase of Type 1 Diabetes Mellitus

2003 • 137 citations

Leukocyte-Endothelium Interaction During the Early Stages of Hypercholesterolemia in the Rabbit

1998 • 132 citations

Oxidative Stress and Platelet Activation in Homozygous Homocystinuria

2001 • 130 citations

Incidence trends and mortality in end-stage renal disease attributed to renovascular disease in the United States

2001 • 123 citations

Low-Density Lipoprotein Level Reduction by the 3-Hydroxy-3-Methylglutaryl Coenzyme-A Inhibitor Simvastatin Is Accompanied by a Related Reduction of F ₂ -Isoprostane Formation in Hypercholesterolemic Subjects

2002 • 116 citations

Effects of Vitamin E Supplementation on F ₂ -Isoprostane and Thromboxane Biosynthesis in Healthy Cigarette Smokers

2000 • 110 citations

Oxidized lipids as mediators of coronary heart disease

2002 • 110 citations

F2-isoprostane evidence of oxidant stress in the insulin resistant, obese Zucker rat: effects of vitamin E

1999 • 102 citations

Lipoprotein Oxidation and Lipoprotein-lnduced Cell Injury in Diabetes

1992 • 91 citations

Lipid Peroxidation Is Not Increased in Patients With Untreated Mild-to-Moderate Hypertension

2003 • 86 citations

Reduced plasma peroxyl radical trapping capacity and increased susceptibility of LDL to oxidation in poorly controlled IDDM

1994 • 84 citations

Vitamin E Reduces Progression of Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice With Established Vascular Lesions

2003 • 74 citations

Lipid Peroxidation and Platelet Activation in Murine Atherosclerosis

2001 • 39 citations

Thromboxane Biosynthesis, Neutrophil and Coagulative Activation in Type IIa Hypercholesterolemia

1995 • 34 citations

Helicobacter Pylori Infection Causes Persistent Platelet Activation In Vivo Through Enhanced Lipid Peroxidation

2004 • 33 citations

The susceptibility of low-density lipoprotein to in vitro oxidation is increased in hypercholesterolemic patients.

1994 • 28 citations

β ₂ Integrin-Dependent Neutrophil Adhesion Induced by Minimally Modified Low-Density Lipoproteins Is Mainly Mediated by F ₂ -Isoprostanes

2002 • 25 citations

Oxidative stress and platelet activation in diabetes mellitus

1996 • 21 citations

Should intensive cholesterol lowering play a role in the management of acute coronary syndromes?

2000 • 7 citations