The Mitochondrial Uncoupling Protein UCP1: A Gated Pore

Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria

1994 • 2,954 citations

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

1997 • 1,647 citations

Thermogenic mechanisms in brown fat.

1984 • 1,593 citations

A Functional-Phylogenetic Classification System for Transmembrane Solute Transporters

2000 • 811 citations

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

2000 • 770 citations

Brown fat and thermogenesis.

1969 • 696 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Brown‐Adipose‐Tissue Mitochondria: Photoaffinity Labelling of the Regulatory Site of Energy Dissipation

1978 • 400 citations

Structure and function of the uncoupling protein from brown adipose tissue

1999 • 360 citations

Coenzyme Q is an obligatory cofactor for uncoupling protein function

2000 • 327 citations

The uncoupling proteins, a review

1998 • 269 citations

The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins

1996 • 246 citations

Solute carriers involved in energy transfer of mitochondria form a homologous protein family

1987 • 222 citations

The mitochondrial transport protein superfamily

1993 • 213 citations

The mitochondrial ADP/ATP carrier: Structural, physiological and pathological aspects

1998 • 207 citations

Kinetic properties of ion carriers and channels

1980 • 205 citations

Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2

1999 • 192 citations

Brown‐adipose‐tissue mitochondria: the regulation of the 32 000‐M_r uncoupling protein by fatty acids and purine nucleotides

1983 • 183 citations

The ADP-ATP Carrier in Mitochondrial Membranes

1976 • 181 citations

Uncoupling proteins: the issues from a biochemist point of view

2001 • 168 citations

The mechanism of proton transport mediated by mitochondrial uncoupling proteins

1998 • 164 citations

Carboxyatractylate inhibits the uncoupling effect of free fatty acids

1988 • 143 citations

Fatty Acids as Acute Regulators of the Proton Conductance of Hamster Brown‐Fat Mitochondria

1982 • 140 citations

Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance

2000 • 133 citations

Brown-Adipose-Tissue Mitochondria. The Influence of Albumin and Nucleotides on Passive Ion Permeabilities

1973 • 130 citations

Anion carriers in fatty acid-mediated physiological uncoupling.

1999 • 128 citations

Characterization of cysteine residues of mitochondrial ADP/ATP carrier with the SH-reagents eosin 5-maleimide and N-ethylmaleimide.

1993 • 124 citations

A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein.

1994 • 114 citations

Translocation of Loops Regulates Transport Activity of Mitochondrial ADP/ATP Carrier Deduced from Formation of a Specific Intermolecular Disulfide Bridge Catalyzed by Copper-o-Phenanthroline

1995 • 106 citations

New substrates and competitive inhibitors of the Cl- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria.

1990 • 104 citations

H⁺ Transport by Uncoupling Protein (UCP-1) Is Dependent on a Histidine Pair, Absent in UCP-2 and UCP-3

1998 • 100 citations

Pore-like and carrier-like properties of the mitochondrial aspartate/glutamate carrier after modification by SH-reagents: evidence for a preformed channel as a structural requirement of carrier-mediated transport

1990 • 100 citations

Dialectics in carrier research: The ADP/ATP carrier and the uncoupling protein

1993 • 95 citations

Identification by Site-directed Mutagenesis of Three Arginines in Uncoupling Protein That Are Essential for Nucleotide Binding and Inhibition

1997 • 94 citations

Nucleotide binding to uncoupling protein. Mechanism of control by protonation

1988 • 94 citations

Mapping of the nucleotide-binding sites in the ADP/ATP carrier of beef heart mitochondria by photolabeling with 2-azido[.alpha.-32P]adenosine diphosphate

1988 • 85 citations

Vectorial Metabolism and the Evolution of Transport Systems

2000 • 84 citations

Functional properties of purified and reconstituted mitochondrial metabolite carriers

1993 • 81 citations

Site-Directed Mutagenesis Identifies Residues in Uncoupling Protein (UCP1) Involved in Three Different Functions

2000 • 76 citations

The Reversible Antiport-Uniport Conversion of the Phosphate Carrier from Yeast Mitochondria Depends on the Presence of a Single Cysteine

1997 • 75 citations

Dynamics of ion transport systems in membranes

1987 • 72 citations

A structure–activity study of fatty acid interaction with mitochondrial uncoupling protein

1997 • 70 citations

Functional principles of solute transport systems: concepts and perspectives

1994 • 69 citations

Importance of Loops of Mitochondrial ADP/ATP Carrier for Its Transport Activity Deduced from Reactivities of its Cysteine Residues with the Sulfhydryl Reagent Eosin-5-maleimide

1994 • 68 citations

Physiological regulation of the transport activity in the uncoupling proteins UCP1 and UCP2

2001 • 67 citations

Neutralization of a Conserved Amino Acid Residue in the Human Na+/Glucose Transporter (hSGLT1) Generates a Glucose-gated H+ Channel

2001 • 64 citations

Inactive fatty acids are unable to flip-flop across the lipid bilayer

1997 • 64 citations

Photoaffinity labeling of the nucleotide‐binding site of the uncoupling protein from hamster brown adipose tissue

1992 • 57 citations

Ion channel properties of the reconstituted chloroplast triose phosphate/phosphate translocator.

1994 • 55 citations

Functional properties of the reconstituted phosphate carrier from bovine heart mitochondria: Evidence for asymmetric orientation and characterization of three different transport modes

1993 • 55 citations

Chloride Channel Properties of the Uncoupling Protein from Brown Adipose Tissue Mitochondria: A Patch-Clamp Study

1996 • 53 citations

Regulation of the uncoupling protein in brown adipose tissue.

1986 • 52 citations

Fluctuation of the First Loop Facing the Matrix of the Mitochondrial ADP/ATP Carrier Deduced from Intermolecular Cross-Linking of Cys⁵⁶ Residues by Bifunctional Dimaleimides

1998 • 51 citations

Labeling of two different regions of the nucleotide binding site of the uncoupling protein from brown adipose tissue mitochondria with two ATP-analogs

1992 • 50 citations

The Yeast Mitochondrial Citrate Transport Protein

2000 • 50 citations

Identification of the pH Sensor for Nucleotide Binding in the Uncoupling Protein from Brown Adipose Tissue

1997 • 46 citations

The mitochondrial carnitine carrier: characterization of SH-groups relevant for its transport function

1992 • 44 citations

Mechanism of action of norepinephrine in hamster brown adipocytes.

1982 • 44 citations

Patch clamp investigation into the phosphate carrier from Saccharomyces cerevisiae mitochondria

1997 • 43 citations

Binding of the Fluorescein Derivative Eosin Y to the Mitochondrial ADP/ATP Carrier: Characterization of the Adenine Nucleotide Binding Site

1998 • 42 citations

A covalent tandem dimer of the mitochondrial ADP/ATP carrier is functional in vivo

2000 • 37 citations

Deletion of Amino Acids 261−269 in the Brown Fat Uncoupling Protein Converts the Carrier into a Pore

1997 • 36 citations

Functional Expression of the Tandem-Repeated Homodimer of the Mitochondrial ADP/ATP Carrier in Saccharomyces cerevisiae

1999 • 36 citations

Structural and functional study of a conserved region in the uncoupling protein UCP1: the three matrix loops are involved in the control of transport

1999 • 36 citations

In the Uncoupling Protein (UCP-1) His-214 Is Involved in the Regulation of Purine Nucleoside Triphosphate but Not Diphosphate Binding

1998 • 34 citations

Does Cytoplasmic Alkalinization Trigger Mitochondrial Energy Dissipation in the Brown Adipocyte?

1978 • 32 citations

The Structural Specificity of the Nucleotide-Binding Site and the Reversible Nature of the Inhibition of Proton Conductance Induced by Bound Nucleotides in Brown-Adipose-Tissue Mitochondria

1977 • 30 citations

Chemical modification of the brown‐fat‐mitochondrial uncoupling protein with tetranitromethane and N‐ethylmaleimide

1986 • 26 citations

Effect of pH and MgCl₂ on the binding of purine nucleotides to the uncoupling protein in membrane particles from brown fat mitochondria

1994 • 22 citations

Effect of hydrophobic sulphydryl reagents on the uncoupling protein and inner‐membrane anion channel of brown‐adipose‐tissue mitochondria

1989 • 18 citations

Kinetic and energetic characterization of solute flux through the reconstituted aspartate/glutamate carrier from beef heart mitochondria after modification with mercurials

1995 • 9 citations

Channel Properties of Mitochondrial Carriers

1994 • 8 citations

Interpreting the effects of specific protein modification on antiport coupling mechanisms: the case of the aspartate/glutamate exchanger

1995 • 5 citations