Expression of Endogenous OncogenicV600EB-rafInduces Proliferation and Developmental Defects in Mice and Transformation of Primary Fibroblasts

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Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

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Inducible Gene Targeting in Mice

1995 • 1,897 citations

High frequency of BRAF mutations in nevi

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High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.

2003 • 1,490 citations

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

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RAF/RAS oncogenes and mismatch-repair status

2002 • 1,205 citations

The RAF proteins take centre stage

2004 • 1,158 citations

The p16INK4a/CDKN2A tumor suppressor and its relatives

1998 • 917 citations

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1998 • 912 citations

Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma

2003 • 829 citations

Guilty as charged

2004 • 783 citations

Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

2004 • 780 citations

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

2003 • 671 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Targeted disruption of the three Rb-related genes leads to loss of G₁ control and immortalization

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

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Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

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Genetic Interaction Between NRAS and BRAF Mutations and PTEN/MMAC1 Inactivation in Melanoma

2004 • 470 citations

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21^Cip1

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Raf proteins and cancer: B-Raf is identified as a mutational target

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Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

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B-RAF is a therapeutic target in melanoma

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High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines.

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Suppression of BRAF(V599E) in human melanoma abrogates transformation.

2003 • 412 citations

Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.

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V599EB-RAF is an Oncogene in Melanocytes

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MEK kinase activity is not necessary for Raf-1 function

2001 • 308 citations

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

2003 • 297 citations

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

2004 • 264 citations

Mutations of the BRAF Gene in Benign and Malignant Melanocytic Lesions

2003 • 227 citations

Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference

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Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

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Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611

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Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT

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B-Raf Acts via the ROCKII/LIMK/Cofilin Pathway To Maintain Actin Stress Fibers in Fibroblasts

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Avian carcinoma virus MH2 contains a transformation-specific sequence, mht, and shares the myc sequence with MC29, CMII, and OK10 viruses.

1983 • 76 citations

BRAF mutations in non-Hodgkin's lymphoma

2003 • 69 citations

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

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Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice.

2002 • 41 citations

Expression of the A-raf proto-oncogene in the normal adult and embryonic mouse.

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Regulation of the p53 pathway by Ras, the plot thickens

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A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression

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raf oncogenes in carcinogenesis.

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