Defining the requirements for immunological control of mycobacterial infections

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

1989 • 1,269 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin

1998 • 1,019 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

1992 • 771 citations

Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis

1997 • 696 citations

Structural Deficiencies in Granuloma Formation in TNF Gene-Targeted Mice Underlie the Heightened Susceptibility to Aerosol Mycobacterium tuberculosis Infection, Which Is Not Compensated for by Lymphotoxin

1999 • 612 citations

IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi.

1997 • 350 citations

Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria

1998 • 327 citations

Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions.

1995 • 265 citations

A receptor for interleukin 10 is related to interferon receptors.

1993 • 233 citations

T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection.

1997 • 228 citations

Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii

1997 • 197 citations

Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice

1999 • 188 citations

Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection

1994 • 182 citations

Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype.

1993 • 181 citations

The protective immune response to Mycobacterium tuberculosis

1995 • 178 citations

Mice incapable of making IL-4 or IL-10 display normal resistance to infection withMycobacterium tuberculosis

1998 • 174 citations

The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms

1997 • 166 citations

Analysis of the local kinetics and localization of interleukin‐1α, tumour necrosis‘qc factor‐α and transforming growth factor‐β, during the course of experimental pulmonary tuberculosis

1997 • 146 citations

Lack of Both Types 1 and 2 Cytokines, Tissue Inflammatory Responses, and Immune Protection During Pulmonary Infection byMycobacterium bovisBacille Calmette-Guérin in IL-12-Deficient Mice

1998 • 140 citations

Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice

1997 • 138 citations

Induction of in vitro human macrophage anti-Mycobacterium tuberculosis activity: requirement for IFN-gamma and primed lymphocytes.

1998 • 137 citations

Improved clearance of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene.

1999 • 130 citations

Corynebacterium parvum- and Mycobacterium bovis bacillus Calmette-Guerin-induced granuloma formation is inhibited in TNF receptor I (TNF-RI) knockout mice and by treatment with soluble TNF-RI.

1996 • 118 citations

Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse.

1996 • 115 citations

Induction of In Vitro Human Macrophage Anti-Mycobacterium tuberculosis Activity: Requirement for IFN-γ and Primed Lymphocytes

1998 • 112 citations

High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections: Synergistic action of TNF and IFN‐γ in the differentiation of protective granulomas

1997 • 106 citations

Improved Clearance of Mycobacterium avium Upon Disruption of the Inducible Nitric Oxide Synthase Gene

1999 • 104 citations

The Role of TGFβ in the Pathogenesis of Human Tuberculosis

1998 • 96 citations

Hematopoietic Remodeling in Interferon-γ–Deficient Mice Infected With Mycobacteria

1998 • 85 citations

Early Inhibition of Mycobacterial Growth by Human Alveolar Macrophages is not Due to Nitric Oxide

1998 • 76 citations

Mycobacterium tuberculosis-driven processes in gene-disrupted mice

1997 • 12 citations