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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

Data up to Jan 2025

Published2006
Citations712
References30

Total Citations Per Year

Abstract

References (30)

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

1995 • 2,199 citations

The Conformational Plasticity of Protein Kinases

2002 • 1,691 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

Regulation of Protein Kinases

2004 • 1,103 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism

1999 • 850 citations

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

2003 • 843 citations

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

2002 • 818 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Structural Basis for Control by Phosphorylation

2001 • 600 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain

2006 • 305 citations

Multiple modes of ligand recognition: Crystal structures of cyclin‐dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

1995 • 273 citations

Structure and Regulation of the CDK5-p25nck5a Complex

2001 • 270 citations

Dynamics of signaling by PKA

2005 • 245 citations

Activation Loop Phosphorylation and Catalysis in Protein Kinases: Is There Functional Evidence for the Autoinhibitor Model?

2002 • 229 citations

The cAMP binding domain: An ancient signaling module

2004 • 203 citations

BioLayout—an automatic graph layout algorithm for similarity visualization

2001 • 156 citations

Did Protein Kinase Regulatory Mechanisms Evolve Through Elaboration of a Simple Structural Component?

2005 • 155 citations

NMR Characterization of Kinase p38 Dynamics in Free and Ligand‐Bound Forms

2005 • 143 citations

Structural Modes of Stabilization of Permissive Phosphorylation Sites in Protein Kinases: Distinct Strategies in Ser/Thr and Tyr Kinases

2004 • 139 citations

Structural aspects of protein kinase control—role of conformational flexibility

2002 • 90 citations

Catalytic Independent Functions of a Protein Kinase as Revealed by a Kinase-dead Mutant: Study of the Lys72His Mutant of cAMP-dependent Kinase

2005 • 84 citations

Molecular Motions of Human Cyclin-dependent Kinase 2

2005 • 52 citations

Hydrogen Exchange Solvent Protection by an ATP Analogue Reveals Conformational Changes in ERK2 upon Activation

2005 • 47 citations

The protein kinase activity modulation sites:

2001 • 43 citations

Release of ADP from the catalytic subunit of protein kinase A: A molecular dynamics simulation study

2004 • 40 citations

MAP Kinases and CDKs: Kinetic Basis for Catalytic Activation

2003 • 31 citations

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Surface comparison of active and inactive protein kinases identifies a conserved… (2006) – Proceedings of the National Academy of Sciences | Metascience Observatory Explorer