Intron Distribution in Ancient Paralogs Supports Random Insertion and Not Random Loss

Amino acid substitution matrices from protein blocks.

1992 • 5,998 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Why genes in pieces?

1978 • 2,256 citations

Evolutionary relationship of archaebacteria, eubacteria, and eukaryotes inferred from phylogenetic trees of duplicated genes.

1989 • 906 citations

Evolution of the vacuolar H+-ATPase: implications for the origin of eukaryotes.

1989 • 776 citations

The Exon Theory of Genes

1987 • 395 citations

Intron phylogeny: a new hypothesis

1991 • 361 citations

The recent origins of introns

1991 • 263 citations

Evidence that introns arose at proto-splice sites.

1989 • 235 citations

How Big Is the Universe of Exons?

1990 • 228 citations

Testing the Exon Theory of Genes: The Evidence from Protein Structure

1994 • 217 citations

On the ancient nature of introns

1993 • 140 citations

Seven newly discovered intron positions in the triose-phosphate isomerase gene: evidence for the introns-late theory.

1995 • 134 citations

How were introns inserted into nuclear genes?

1989 • 131 citations

[21] Progressive alignment of amino acid sequences and construction of phylogenetic trees from them

1996 • 127 citations

Five identical intron positions in ancient duplicated genes of eubacterial origin

1994 • 110 citations

Structure of vertebrate genes: A statistical analysis implicating selection

1988 • 77 citations

Intron positions in actin genes seem unrelated to the secondary structure of the protein.

1994 • 60 citations

Evidence against the exon theory of genes derived from the triose-phosphate isomerase gene.

1995 • 46 citations

Evolutionary history of introns in a multidomain globin gene

1996 • 43 citations

Compartmentalized isozyme genes and the origin of introns

1990 • 30 citations

Slippery introns and globin gene evolution

1993 • 28 citations

The complete amino acid sequences of cytosolic and mitochondrial aspartate aminotransferases from horse heart, and inferences on evolution of the isoenzymes

1986 • 27 citations

Analysis of the introns in genes encoding small G proteins

1994 • 22 citations

Eukaryotic genes: Are introns structural elements or evolutionary debris?

1985 • 19 citations

Introns between protein domains: selective insertion or frameshifting?

1986 • 19 citations