2.8-.ANG. Structure of Yeast Serine Carboxypeptidase

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Solvent content of protein crystals

1968 • 7,954 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

The α/β hydrolase fold

1992 • 2,024 citations

A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex

1991 • 1,112 citations

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

An efficient general-purpose least-squares refinement program for macromolecular structures

1987 • 871 citations

Using known substructures in protein model building and crystallography.

1986 • 766 citations

How different amino acid sequences determine similar protein structures: The structure and evolutionary dynamics of the globins

1980 • 697 citations

Three-dimensional Structure of Tosyl-α-chymotrypsin

1967 • 609 citations

Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum

1991 • 534 citations

Fusarium solani cutinase is a lipolytic enzyme with a catalytic serine accessible to solvent

1992 • 406 citations

Protein sorting in yeast: The localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide

1987 • 329 citations

The molecular chaperone concept.

1990 • 311 citations

Exploring structural homology of proteins

1976 • 289 citations

A protein-folding reaction under kinetic control

1992 • 284 citations

Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin

1981 • 266 citations

[28] Software for a diffractometer with multiwire area detector

1985 • 263 citations

Low-barrier hydrogen bonds and low fractionation factor bases in enzymic reactions

1992 • 250 citations

Engineering Enzyme Specificity by "Substrate-Assisted Catalysis"

1987 • 219 citations

Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y.

1986 • 217 citations

The essential function of yeast protein disulfide isomerase does not reside in its isomerase activity

1993 • 201 citations

Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A

1973 • 193 citations

Serine carboxypeptidases. A review

1986 • 183 citations

Propeptide of carboxypeptidase Y provides a chaperone-like function as well as inhibition of the enzymatic activity.

1991 • 173 citations

X-Ray Studies of Protein Interactions

1974 • 150 citations

Conjugate-direction minimization: an improved method for the refinement of macromolecules

1992 • 148 citations

Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids.

1990 • 147 citations

Acetylcholinesterase: electrostatic steering increases the rate of ligand binding

1993 • 144 citations

Refined atomic model of wheat serine carboxypeptidase II at 2.2-.ANG. resolution

1992 • 125 citations

Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families

1993 • 112 citations

An unusual buried polar cluster in a family of fungal lipases

1994 • 112 citations

Structure of wheat serine carboxypeptidase II at 3.5-A resolution. A new class of serine proteinase.

1990 • 105 citations

Isolation of carboxypeptidase Y by affinity chromatography

1976 • 96 citations

Serine at the Active Center of Yeast Carboxypeptidase

1973 • 92 citations

Analogous inhibitors of elastase do not always bind analogously

1994 • 90 citations

Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity

1991 • 83 citations

A gibberellin responsive wheat gene has homology to yeast carboxypeptidase Y.

1987 • 80 citations

Revision of the oligosaccharide structures of yeast carboxypeptidase Y.

1990 • 72 citations

Characterization of the yeast KEX1 gene product: a carboxypeptidase involved in processing secreted precursor proteins.

1989 • 72 citations

Evidence for an essential histidine in carboxypeptidase Y. Reaction with the chloromethyl ketone derivative of benzyloxycarbonyl-L-phenylalanine.

1975 • 67 citations

Secondary structure of the mammalian 70-kilodalton heat shock cognate protein analyzed by circular dichroism spectroscopy and secondary structure prediction

1990 • 60 citations

Properties of the single sulfhydryl group of carboxypeptidase Y. Effects of alkyl and aromatic mercurials on activities toward various synthetic substrates.

1979 • 52 citations

Crystal structure of the complex between carboxypeptidase A and the biproduct analog inhibitor l-benzylsuccinate at 2·0 Å resolution

1992 • 50 citations

X-ray crystallographic structure of dienelactone hydrolase at 2.8 Å

1988 • 46 citations

Site-directed mutagenesis on (serine) carboxypeptidase Y. A hydrogen bond network stabilizes the transition state by interaction with the C-terminal carboxylate group of the substrate

1994 • 41 citations

Modification of the single sulfhydryl group of carboxypeptidase Y with mercurials. Influence on enzyme specificity

1983 • 38 citations

Structure and expression during the germination of rice seeds of the gene for a carboxypeptidase

1992 • 32 citations

Identification of methionyl and cysteinyl residues in the substrate binding site of carboxypeptidase Y

1984 • 29 citations

The pro region required for folding of carboxypeptidase Y is a partially folded domain with little regular structural core

1993 • 26 citations

[38] Human prolylcarboxypeptidase

1981 • 25 citations

Inactivation of carboxypeptidase Y by mutational removal of the putative essential histidyl residue

1989 • 23 citations

Altering substrate preference of carboxypeptidase Y by a novel strategy of mutagenesis eliminating wild type background

1993 • 21 citations

Increased hydrophobicity of the S′1 binding site in carboxypeptidase Y obtained by site-directed mutagenesis

1985 • 19 citations

The free sulfhydryl group (Cys341) of carboxypeptidase Y: Functional effects of mutational substitutions

1987 • 16 citations

The primary structure of carboxypeptidase S1 from Penicillium janthinellum

1993 • 14 citations

Cyanylation of the single sulfhydryl group in carboxypeptidase Y with cyanogen bromide

1987 • 9 citations

Mutational replacement of methionine by arginine in the S′1 substrate binding site of yeast carboxypeptidase

1986 • 4 citations