Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature.

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Tumor necrosis factor.

1992 • 601 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.

1987 • 533 citations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

1989 • 473 citations

The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity.

1988 • 276 citations

Tumor Necrosis Factor

1988 • 261 citations

Acute in vivo effects of human recombinant tumor necrosis factor.

1987 • 256 citations

Endothelial cells stimulated with tumor necrosis factor-alpha express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system. Effects of thrombin inhibitors.

1994 • 150 citations

Gene therapy targeted by radiation preferentially radiosensitizes tumor cells.

1994 • 143 citations

Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown.

1990 • 114 citations

TNF modulates endothelial properties by decreasing cAMP

1995 • 111 citations

Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells

1994 • 106 citations

The interaction between recombinant human tumor necrosis factor and radiation in 13 human tumor cell lines

1990 • 104 citations

Cytokine levels and systemic toxicity in patients undergoing isolated limb perfusion with high-dose tumor necrosis factor, interferon gamma, and melphalan.

1995 • 103 citations

Tumor necrosis factor alpha selectively sensitizes human immunodeficiency virus-infected cells to heat and radiation.

1991 • 93 citations

Low-dose tumour necrosis factor α and melphalan in hyperthermic isolated limb perfusion

1993 • 87 citations

Quantitation and kinetics of blood monocyte migration to acute inflammatory reactions, and IL-1 alpha, tumor necrosis factor-alpha, and IFN-gamma.

1993 • 86 citations

The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration.

1993 • 77 citations

TNF-alpha is a principal cytokine involved in the recruitment of NK cells to liver parenchyma.

1994 • 47 citations

Experimental thrombosis model induced by free radicals. Application to aspirin and other different substances

1995 • 44 citations

Gene therapy for cancer

1995 • 27 citations

Tumor necrosis factor α induces early morphologic and metabolic alterations in friend leukemia cell tumors and fibrosarcomas in mice

1988 • 26 citations

Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice.

1990 • 23 citations