Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Expression cloning and cDNA sequencing of the Na+/glucose co-transporter

1987 • 995 citations

Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe

1976 • 906 citations

[12] Unidirectional digestion with exonuclease III in DNA sequence analysis

1987 • 898 citations

The detection and classification of membrane-spanning proteins

1985 • 854 citations

Genetic control of cell size at cell division in yeast

1975 • 846 citations

Molecular cloning, primary structure, and expression of the human growth factor-activatable antiporter

1989 • 774 citations

The fungal vacuole: composition, function, and biogenesis

1990 • 758 citations

Mechanisms of regulation of the Na+/H+ exchanger

1986 • 685 citations

P‐glycoprotein: multidrug‐resistance and a superfamily of membrane‐associated transport proteins

1989 • 512 citations

Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones

1990 • 479 citations

Recent progress in understanding mechanisms of mammalian DNA amplification

1989 • 469 citations

Growth Factors Induce Phosphorylation of the Na ⁺ /H ⁺ Antiporter, a Glycoprotein of 110 kD

1990 • 452 citations

pH homesstasis in bacteria

1981 • 427 citations

Mammalian and bacterial sugar transport proteins are homologous

1987 • 400 citations

The Proton Electrochemical Gradient in Escherichia coli Cells

1976 • 391 citations

A novel P‐type ATPase from yeast involved in sodium transport

1991 • 362 citations

TRK1 encodes a plasma membrane protein required for high-affinity potassium transport in Saccharomyces cerevisiae.

1988 • 291 citations

The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast.

1987 • 257 citations

Characterization of a Na+/H+ antiporter gene of Escherichia coli.

1987 • 209 citations

High-sensitivity S1 mapping with single-stranded [32PIDNA probes synthesized from bacteriophage M13mp templates

1984 • 188 citations

Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.

1991 • 178 citations

Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe.

1987 • 158 citations

Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon, Tn10. The role of the conserved dipeptide, Ser65-Asp66, in tetracycline transport.

1990 • 150 citations

A family of closely related ATP‐binding subunits from prokaryotic and eukaryotic cells

1988 • 146 citations

Sequencing of the gene ant which affects the Na+/H+ antiporter activity in Escherichia coli.

1988 • 142 citations

Analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe.

1986 • 130 citations

Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae

1986 • 125 citations

Sequence and structure of the yeast galactose transporter

1989 • 110 citations

Co-transport of Na+ and methyl-β-D-thiogalactopyranoside mediated by the melibiose transport system of Escherichia coli

1977 • 109 citations

Bioenergetics of alkalophilic bacteria

1986 • 103 citations

TRK1 Encodes a Plasma Membrane Protein Required for High-Affinity Potassium Transport in Saccharomyces cerevisiae

1988 • 87 citations

Structure of DNA formed in the first step of CAD gene amplification.

1986 • 78 citations

Nuclear pre-mRNA splicing in the fission yeast Schizosaccharomyces pombe strictly requires an intron-contained, conserved sequence element.

1987 • 67 citations

Isolation and properties of fibroblast mutants overexpressing an altered Na+/H+ antiporter.

1986 • 66 citations

Escherichia coli kgtP encodes an alpha-ketoglutarate transporter.

1991 • 66 citations

Suc1⁺ Encodes a Predicted 13-Kilodalton Protein that is Essential for Cell Viability and is Directly Involved in the Division Cycle of Schizosaccharomyces pombe

1987 • 51 citations

Transient increase in Ca2+ influx in Saccharomyces cerevisiae in response to glucose: effects of intracellular acidification and cAMP levels

1990 • 45 citations

The mechanism of sodium efflux in yeast

1982 • 40 citations

Isolation and properties of a mutant of Escherichia coli possessing defective Na+/H+ antiporter.

1987 • 37 citations

An efflux mechanism determines the low net entry of lithium in yeasts

1977 • 31 citations

Defective cation-coupling mutants of Escherichia coli Na+/proline symport carrier. Characterization and localization of mutations.

1990 • 28 citations

Meiotic Gene Conversion Mediates Gene Amplification in Yeast

1984 • 27 citations

Energy source for lithium efflux in yeast

1981 • 27 citations

Alkalophilic Bacillus firmus RAB generates variants which can grow at lower Na+ concentrations than the parental strain

1986 • 14 citations