Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Activation of Orphan Receptors by the Hormone Relaxin

2002 • 789 citations

Cryptorchidism in mice mutant for Insl3

1999 • 719 citations

Targeted Disruption of the Insl3 Gene Causes Bilateral Cryptorchidism

1999 • 658 citations

INSL3/Leydig Insulin-like Peptide Activates the LGR8 Receptor Important in Testis Descent

2002 • 407 citations

Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells.

1993 • 282 citations

Mutations of the GREAT gene cause cryptorchidism

2002 • 237 citations

A transgenic insertion causing cryptorchidism in mice

2001 • 231 citations

Targeted Disruption of the Insl3 Gene Causes Bilateral Cryptorchidism

1999 • 185 citations

The affinity of (?)-propranolol for ? 1- and ? 1-autoreceptors of human heart

1985 • 175 citations

Relaxin-Like Factor Expression as a Marker of Differentiation in the Mouse Testis and Ovary¹

1998 • 167 citations

Mouse Leydig insulin-like (Ley I-L) gene: Structure and expression during testis and ovary development

1997 • 151 citations

Autoradiographic localization of relaxin binding sites in rat brain.

1991 • 138 citations

Cardiac effects of relaxin in rats

1992 • 120 citations

Insulin-like 3/Relaxin-Like Factor Gene Mutations Are Associated with Cryptorchidism1

2000 • 115 citations

X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.

1991 • 112 citations

Relaxin-Like Factor Gene is Highly Expressed in the Bovine Ovary of the Cycle and Pregnancy: Sequence and Messenger Ribonucleic Acid Analysis1

1996 • 111 citations

A Novel Leydig Cell cDNA-derived Protein Is a Relaxin-like Factor

1995 • 107 citations

Molecular cloning and expression of the relaxin-like factor from the mouse testis.

1996 • 102 citations

Relaxin-like factor: a highly specific and constitutive new marker for Leydig cells in the human testis

1997 • 100 citations

Relaxin alters the plasma osmolality-arginine vasopressin relationship in the rat

1993 • 96 citations

The Relaxin Receptor-binding Site Geometry Suggests a Novel Gripping Mode of Interaction

2000 • 96 citations

Relaxin has conformational homology with insulin

1977 • 93 citations

The receptor-binding site of human relaxin II. A dual prong-binding mechanism

1992 • 90 citations

Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment

1999 • 86 citations

Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism

2000 • 81 citations

Relaxin affects the central control of oxytocin release

1984 • 79 citations

Genetic analysis of the INSL3 gene in patients with maldescent of the testis

2001 • 78 citations

A Common Polymorphism in the Human Relaxin-Like Factor (RLF) Gene: No Relationship with Cryptorchidism

2000 • 77 citations

Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis

1987 • 74 citations

Structure and expression of Leydig insulin-like peptide mRNA in the sheep

1996 • 74 citations

Relaxin increases the firing rate of supraoptic neurones and increases oxytocin secretion in the rat

1992 • 73 citations

A human cDNA coding for the Leydig insulin-like peptide (Ley I-L)

1994 • 71 citations

Preparation of biologically active 32P-labeled human relaxin. Displaceable binding to rat uterus, cervix, and brain.

1990 • 70 citations

Relaxin and its structural relationship to insulin

1978 • 68 citations

Structure and expression of the rat relaxin-like factor (RLF) gene

1999 • 67 citations

Relaxin-Like Factor Expression as a Marker of Differentiation in the Mouse Testis and Ovary

1998 • 65 citations

Comparison of relaxin receptors in rat isolated atria and uterus by use of synthetic and native relaxin analogues

1998 • 65 citations

Tryptophan B27 in the Relaxin-like Factor (RLF) Is Crucial for RLF Receptor-Binding

1999 • 64 citations

The Relaxin-Like Factor Is a Hormone

1999 • 62 citations

Distribution of Fos Immunoreactivity in the Lamina Terminalis and Hypothalamus Induced by Centrally Administered Relaxin in Conscious Rats

1997 • 60 citations

Lesion of the subfornical organ affects the haemotensive response to centrally administered relaxin in anaesthetized rats

1989 • 57 citations

Insulin-like 3/Relaxin-Like Factor Gene Mutations Are Associated with Cryptorchidism

2000 • 55 citations

The human Leydig insulin-like (hLEY I-L) gene is expressed in the corpus luteum and trophoblast.

1995 • 54 citations

Relaxin increases rat heart rate by a direct action on the cardiac atrium

1992 • 53 citations

Relaxin-like factor (RLF) serum concentrations and gubernaculum RLF receptor display in relation to pre- and neonatal development of rats

2001 • 52 citations

Expression of relaxin-like factor is down-regulated in human testicular Leydig cell neoplasia

1999 • 52 citations

Molecular cloning and expression of the relaxin-like factor from the mouse testis

1996 • 47 citations

A single-copy relaxin-like gene sequence is present in sheep

1993 • 45 citations

Mechanism of the Haemotensive Action of Porcine Relaxin in Anaesthetized Rats

1990 • 40 citations

Different insulin-like 3 (INSL3) gene mutations not associated with human cryptorchidism

2001 • 37 citations

Solid‐phase synthesis of ovine Leydig cell insulin‐like peptide – a putative ovine relaxin?

1999 • 32 citations

The human Leydig insulin-like (hLEY I-L) gene is expressed in the corpus luteum and trophoblast

1995 • 23 citations

Chemical synthesis and relaxin activity of analogues of ovine Insulin 3 containing specific B-chain residue replacements

2001 • 2 citations