Signal flow in visual transduction

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

ENERGY, QUANTA, AND VISION

1942 • 1,101 citations

The photocurrent, noise and spectral sensitivity of rods of the monkey Macaca fascicularis.

1984 • 689 citations

Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions

1988 • 634 citations

A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors.

1992 • 632 citations

Cyclic GMP-Activated Conductance of Retinal Photoreceptor Cells

1989 • 582 citations

Recoverin: a Calcium Sensitive Activator of Retinal Rod Guanylate Cyclase

1991 • 569 citations

Changes in time scale and sensitivity in turtle photoreceptors

1974 • 539 citations

Visual excitation and recovery

1991 • 530 citations

Visual transduction in cones of the monkey Macaca fascicularis.

1990 • 486 citations

Two components of electrical dark noise in toad retinal rod outer segments.

1980 • 462 citations

Farnesylated γ-subunit of photoreceptor G protein indispensable for GTP-binding

1990 • 389 citations

Calcium and light adaptation in retinal rods and cones

1988 • 387 citations

Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment

1985 • 381 citations

Extrusion of calcium from rod outer segments is driven by both sodium and potassium gradients

1989 • 374 citations

Light‐induced binding of 48‐kDa protein to photoreceptor membranes is highly enhanced by phosphorylation of rhodopsin

1984 • 358 citations

Photoreceptor light adaptation is mediated by cytoplasmic calcium concentration

1988 • 349 citations

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1992 • 324 citations

The ionic selectivity and calcium dependence of the light‐sensitive pathway in toad rods.

1985 • 269 citations

THE MOLECULAR MECHANISM OF VISUAL EXCITATION AND ITS RELATION TO THE STRUCTURE AND COMPOSITION OF THE ROD OUTER SEGMENT

1987 • 264 citations

ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes

1980 • 251 citations

Calcium-dependent regulation of cyclic GMP phosphodiesterase by a protein from frog retinal rods

1991 • 242 citations

Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments.

1985 • 211 citations

Light response of vertebrate photoreceptors

1990 • 208 citations

A 26 kd calcium binding protein from bovine rod outer segments as modulator of photoreceptor guanylate cyclase.

1991 • 198 citations

Calcium homeostasis in the outer segments of retinal rods from the tiger salamander.

1992 • 186 citations

Inactivation of photoexcited rhodopsin in retinal rods: the roles of rhodopsin kinase and 48-kDa protein (arrestin)

1988 • 185 citations

Molecular Biology of Visual Pigments

1987 • 168 citations

Phosphorylation of rhodopsin and quenching of cyclic GMP phosphodiesterase activation by ATP at weak bleaches.

1983 • 165 citations

Measurement of the intracellular free calcium concentration in salamander rods

1986 • 153 citations

Calcium modulation of cyclic GMP synthesis in rat visual cells

1982 • 153 citations

The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction

1992 • 151 citations

Incorporation of calcium buffers into salamander retinal rods: a rejection of the calcium hypothesis of phototransduction.

1986 • 150 citations

Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments.

1991 • 149 citations

Cloning, expression, and crystallization of recoverin, a calcium sensor in vision.

1992 • 143 citations

Molecular Properties of the cGMP Cascade of Vertebrate Photoreceptors

1987 • 137 citations

Regulation of Rhodopsin Dephosphorylation by Arrestin

1989 • 134 citations

Kinetics of phototransduction in retinal rods of the newt Triturus cristatus.

1989 • 133 citations

Carboxyl methylation and farnesylation of transducin gamma-subunit synergistically enhance its coupling with metarhodopsin II.

1991 • 130 citations

Guanosine 3',5'‐cyclic monophosphate‐activated conductance studied in a truncated rod outer segment of the toad.

1988 • 119 citations

Effects of temperature changes on toad rod photocurrents.

1984 • 112 citations

Intracellular biochemical manipulation of phototransduction in detached rod outer segments.

1987 • 105 citations

cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse.

1991 • 102 citations

Deactivation kinetics of the transduction cascade of vision.

1991 • 101 citations

Subsecond deactivation of transducin by endogenous GTP hydrolysis

1990 • 95 citations

Phototransduction in cones: An inverse problem in enzyme kinetics

1989 • 78 citations

Spontaneous quantal events induced in toad rods by pigment bleaching

1980 • 68 citations

Interplay of phosphorylation and dephosphorylation in vision: protein phosphatases of bovine rod outer segments

1989 • 61 citations

Phosphorylation at sites near rhodopsin'scarboxyl-terminus regulates light initiated CGMP hydrolysis

1984 • 60 citations

Studies of ligand binding to arrestin

1991 • 31 citations

Ca2+ binding capacity of cytoplasmic proteins from rod photoreceptors is mainly due to arrestin.

1990 • 30 citations

Incorporation of analogues of GTP and GDP into rod photoreceptors isolated from the tiger salamander.

1988 • 30 citations

Phosphorylation of recoverin, the calcium‐sensitive activator of photoreceptor guanylyl cyclase

1991 • 27 citations