Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes*

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1994 • 429 citations

Nomenclature for human CYP2D6 alleles

1996 • 406 citations

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1992 • 406 citations

MEDICAL NEMESIS

1974 • 377 citations

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 • 363 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*

1998 • 284 citations

Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds

1967 • 266 citations

E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation

1981 • 171 citations

Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: Polymorphism in RFLP and DNA sequence of CYP2D6

1993 • 159 citations

Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame-ionization and nitrogen-selective detection

1977 • 155 citations

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism

1993 • 146 citations

Extremely Rapid Hydroxylation of Debrisoquine

1985 • 144 citations

Interindividual and interethnic differences in the demethylation and glucuronidation of codeine.

1989 • 115 citations

Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man

1980 • 111 citations

Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population

1996 • 98 citations

Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects

1995 • 96 citations

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine

1991 • 95 citations

Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses

1973 • 88 citations

Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to theCYP2D6 genotype

1996 • 72 citations

Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

1984 • 71 citations

LIVING AND DYING IN THE NINETEENTH CENTURY.

1963 • 69 citations

Plasma concentrations of nortriptyline and its 10‐hydroxy metabolite in depressed patients‐relationship to the debrisoquine hydroxylation metabolic ratio.

1985 • 69 citations

Active Hydroxymetabolites of Antidepressants

1995 • 67 citations

Formation of morphine from codeine in Chinese subjects of different CYP2D6 genotypes*

1996 • 60 citations

The cytochrome P450 CYP2D6 allelic variant CYP 2D6J and related polymorphisms in a European population

1994 • 55 citations

Propranolol disposition in Chinese subjects of different CYP2D6 genotypes*

1995 • 53 citations

Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level

1972 • 49 citations

Clinical and biochemical effects during treatment of depression with nortriptyline: The role of 10-hydroxynortriptyline

1987 • 44 citations

Differences in Drug Metabolism Polymorphism Between Orientals and Caucasians

1990 • 39 citations

Pharmacokinetic and other related factors affecting psychotropic responses in Asians.

1991 • 32 citations

Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects

1984 • 26 citations

High-performance liquid chromatography–mass spectrometry for the quantification of nortriptyline and 10-hydroxynortriptyline in plasma

1998 • 21 citations

STUDIES PHYSIOLOGICAL AND PRACTICAL

1854 • 9 citations