Propranolol disposition in Chinese subjects of different CYP2D6 genotypes*

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

1989 • 407 citations

Racial Differences in Drug Response

1989 • 236 citations

Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities

1989 • 178 citations

Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: Polymorphism in RFLP and DNA sequence of CYP2D6

1993 • 159 citations

The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site.

1990 • 144 citations

Ethnic differences in response to morphine

1993 • 98 citations

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine

1991 • 95 citations

Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade

1984 • 81 citations

Quinidine reduces clearance of (+)-propranolol more than (−)-propranolol through marked reduction in 4-hydroxylation

1990 • 71 citations

Stereoselective ring oxidation of propranolol in man.

1984 • 67 citations

The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol.

1984 • 66 citations

The cytochrome P450 CYP2D6 allelic variant CYP 2D6J and related polymorphisms in a European population

1994 • 55 citations

Differences in stereoselective disposition of propranolol do not explain sensitivity differences between white and Chinese subjects: Correlation between the clearance of (−)- and (+)-propranolol

1990 • 20 citations