Basic fibroblast growth factor is a neurotropic factor in GT1 gonadotropin-releasing hormone neuronal cell lines.

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Large induction of keratinocyte growth factor expression in the dermis during wound healing.

1992 • 603 citations

Glial growth factor restricts mammalian neural crest stem cells to a glial fate

1994 • 496 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, which has a Unique Secretion Property

1993 • 390 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Differential Splicing in the Extracellular Region of Fibroblast Growth Factor Receptor 1 Generates Receptor Variants with Different Ligand-Binding Specificities

1992 • 321 citations

Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons.

1992 • 281 citations

Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line.

1992 • 263 citations

Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.

1992 • 263 citations

Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.

1993 • 240 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet‐derived growth factor‐like protein which is secreted

1987 • 229 citations

Genesis of olfactory receptor neurons in vitro: Regulation of progenitor cell divisions by fibroblast growth factors

1994 • 192 citations

Involvement of transforming growth factor alpha in the release of luteinizing hormone-releasing hormone from the developing female hypothalamus.

1990 • 169 citations

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

1992 • 156 citations

Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.

1993 • 146 citations

The beta-PDGF receptor induces neuronal differentiation of PC12 cells.

1992 • 145 citations

Differential expression patterns of mRNAs for members of the fibroblast growth factor receptor family, FGFR‐1–FGFR‐4, in rat brain

1994 • 141 citations

Differential expression of two members of FGF receptor gene family, FGFR-1 and FGFR-2 mRNA, in the adult rat central nervous system

1993 • 124 citations

Basic FGF‐like immunoreactivity in the developing and adult rat brainstem

1991 • 102 citations

Fibroblast growth factor receptor‐bearing neurons in the CNS: Identification by receptor‐mediated retrograde transport

1991 • 100 citations

CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neurons

1994 • 92 citations

Temporal, differential and regional expression of mRNA for basic fibroblast growth factor in the developing and adult rat brain

1991 • 90 citations

Developmental expression of the basic fibroblast growth factor gene in rat brain

1991 • 81 citations

Trophic effects of basic fibroblast growth factor on fetal rat hypothalamic cells: interactions with insulin-like growth factor I

1990 • 69 citations

Basic fibroblast growth factor (bFGF), a multifunctional growth factor for neuroectodermal cells

1990 • 67 citations

Overexpression of a human transforming growth factor-alpha (TGF alpha) transgene reveals a dual antagonistic role of TGF alpha in female sexual development.

1994 • 66 citations

Neurotrophic Factor Deprivation‐induced Death

1993 • 56 citations

Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line.

1994 • 37 citations

Basic Fibroblast Growth Factor Enhances Nerve Growth Factor Receptor Gene Promoter Activity in Human Neuroblastoma Cell Line CHP100

1992 • 16 citations