Overexpression of a human transforming growth factor-alpha (TGF alpha) transgene reveals a dual antagonistic role of TGF alpha in female sexual development.

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

A Complete Protocol forIn SituHybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes

1989 • 883 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

The midline of the drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance

1991 • 497 citations

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

1994 • 441 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism.

1992 • 336 citations

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

1987 • 297 citations

EGF and TGF-α stimulate retinal neuroepithelial cell proliferation in vitro

1991 • 286 citations

The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.

1992 • 278 citations

Growth Factors Modulate Gonadotropin Receptor Induction in Granulosa Cell Cultures

1981 • 207 citations

Estrogen receptor-immunoreactive glia, endothelia, and ependyma in guinea pig preoptic area and median eminence: electron microscopy.

1992 • 198 citations

Epidermal growth factor stimulates DNA-synthesis of astrocytes in primary cerebellar cultures

1981 • 197 citations

Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-alpha mRNA in mouse brain by a quantitative nuclease protection assay

1992 • 188 citations

INHIBITION OF OVARIAN AND TESTICULAR STEROIODOGENESIS BY EPIDERMAL GROWTH FACTOR

1981 • 184 citations

Involvement of transforming growth factor alpha in the release of luteinizing hormone-releasing hormone from the developing female hypothalamus.

1990 • 169 citations

Genetic Influences on the Timing of Puberty in Mice1

1990 • 142 citations

OVARIAN TRANSFORMING GROWTH FACTOR-α GENE EXPRESSION: IMMUNOHISTOCHEMICAL LOCALIZATION TO THE THECAINTERSTITIAL CELLS

1987 • 113 citations

Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice

1985 • 108 citations

Region-specific regulation of transforming growth factor alpha (TGF alpha) gene expression in astrocytes of the neuroendocrine brain

1994 • 98 citations

Transforming growth factor alpha contributes to the mechanism by which hypothalamic injury induces precocious puberty.

1991 • 97 citations

Transforming growth factor-α in the mammalian brain

1989 • 94 citations

The Gene Encoding Nerve Growth Factor Is Expressed in the Immature Rat Ovary: Effect of Denervation and Hormonal Treatment*

1990 • 93 citations

Localization of the DER/flb protein in embryos: implications on the faint little ball lethal phenotype

1990 • 82 citations

Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping population of neocortical neurons in vitro

1990 • 80 citations

Secretion of Luteinizing Hormone in Male Mice: Factors that Influence Release during Sexual Encounters*

1980 • 76 citations

Transforming Growth Factor-Alpha in the Adult Bovine Ovary: Identification in Growing Ovarian Follicles1

1989 • 71 citations

Radioimmunoassay of Mouse Luteinizing and Follicle Stimulating Hormones

1972 • 65 citations

Transforming growth factor‐α attenuates the acquisition of aromatase activity by cultured rat granulosa cells

1987 • 64 citations

Comparison between epidermal growth factor, transforming growth factor-α and EGF receptor levels in regions of adult rat brain

1992 • 59 citations

Regional expression of transforming growth factor-α mRNA in the rat central nervous system

1991 • 58 citations

The genes encoding nerve growth factor and its receptor are expressed in the developing female rat hypothalamus

1991 • 57 citations

Epidermal growth factor antagonizes ovarian theca-interstitial cytodifferentiation

1983 • 53 citations

Activation of Estradiol-Positive Feedback at Puberty: Estradiol Sensitizes the LHRH-Releasing System at Two Different Biochemical Steps

1986 • 53 citations

Functional Recovery of the Developing Rat Ovary after Transplantation: Contribution of the Extrinsic Innervation*

1991 • 49 citations

Epidermal growth factor stimulates secretion of rat pituitary luteinizing hormone in vitro

1985 • 41 citations

A Novel Mechanism for the Induction of Aromatase in Ovarian Cells in Vitro: Role of Transforming Growth Factor Alpha-induced Protein Tyrosine Kinase

1991 • 37 citations

Effect of hypothalamic lesions that induce precocious puberty on the morphological and functional maturation of the luteinizing hormone-releasing hormone neuronal system.

1992 • 35 citations

Topographic relations between tyrosine hydroxylase- and luteinizing hormone-releasing hormone-immunoreactive fibers in the median eminence of adult rats

1989 • 24 citations

Some transforming growth factor-alpha connections and their colocalization with enkephalin in the rat central nervous system

1987 • 22 citations

Stimulation of the hypothalamic-pituitary-adrenal axis by epidermal growth factor

1990 • 8 citations

Epidermal growth factor inhibits follicular response to human chorionic gonadotropin: possible role of cell to cell communication in the response to gonadotropin.

1992 • 7 citations