5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

1991 • 360 citations

Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.

1985 • 330 citations

The cellular pharmacology of methotrexate

1985 • 254 citations

Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.

1987 • 251 citations

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

1981 • 242 citations

A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis

1989 • 234 citations

The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells

1989 • 222 citations

The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.

1986 • 140 citations

Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase

1981 • 137 citations

Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cells

1983 • 113 citations

Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.

1983 • 100 citations

The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.

1987 • 83 citations

Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells

1994 • 67 citations

The mechanism of action of methotrexate in cultured L5178Y leukemia cells.

1975 • 66 citations

Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo.

1990 • 61 citations

Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.

1990 • 54 citations

Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase

1992 • 42 citations

Membrane transport alterations as a mechanism of resistance to anticancer agents.

1986 • 38 citations

Activity of the new antifolate N10-propargyl-5,8-dideazafolate and its polyglutamates against human dihydrofolate reductase, human thymidylate synthetase, and KB cells containing different levels of dihydrofolate reductase.

1985 • 36 citations

5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines.

1993 • 30 citations

Purine modulation of methotrexate cytotoxicity in mammalian cell lines.

1982 • 28 citations

Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for (anti)folate compounds

1991 • 27 citations

DNA fragmentation, dATP pool elevation and potentiation of antifolate cytotoxicity in L1210 cells by hypoxanthine

1992 • 25 citations

Deoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblasts.

1986 • 23 citations

Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.

1988 • 21 citations

Modulation of antifolate cytotoxicity by metabolites from dying cells in a lymphocyte clonal assay

1988 • 18 citations

Inhibition of 2-desamino-2-methyl-10-propagyl-5,8-dideazafolic acid cytotoxicity by 5,10-dideazatetrahydrofolate in L1210 cells with decrease in DNA fragmentation and deoxyadenosine triphosphate pools

1991 • 8 citations

Molecular mechanism of cell death induced dNTP pool imbalance.

1993 • 6 citations