Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cells

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

1969 • 779 citations

Regulation of Mammalian Deoxyribonucleotide Biosynthesis by Nucleotides as Activators and Inhibitors

1966 • 395 citations

Human lymphoblastoid lines from lymph node and spleen

1968 • 261 citations

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

1981 • 242 citations

An Isotopic Assay for Thymidylate Synthetase^*

1966 • 212 citations

A method for the determination of dATP and dTTP in picomole amounts

1970 • 206 citations

Mycoplasma contamination of animal cell cultures: A simple, rapid detection method

1972 • 188 citations

Inhibition of Ribosomal Ribonucleic Acid Maturation in Novikoff Hepatoma Cells by 5-Fluorouracil and 5-Fluorouridine

1973 • 157 citations

A rapid quantitative determination of deoxyribonucleoside triphosphates based on the enzymatic synthesis of DNA

1969 • 157 citations

The effect of methotrexate on levels of dUTP in animal cells.

1980 • 128 citations

Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats.

1980 • 104 citations

Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase

1977 • 95 citations

Intrinsic Resistance to Methotrexate of Cultured Mammalian Cells in Relation to the Inhibition Kinetics of Their Dihydrofolate Reductases

1976 • 91 citations

Changes in the deoxyribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil.

1973 • 88 citations

SITES OF ACTION OF AMETHOPTERIN: INTRINSIC AND ACQUIRED DRUG RESISTANCE*

1971 • 87 citations

Factors determining cell sensitivity to methotrexate: Studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines

1974 • 84 citations

Purineless death as a link between growth rate and cytotoxicity by methotrexate.

1972 • 77 citations

Effect of 5-fluorouracil on RNA metabolism in Novikoff hepatoma cells.

1979 • 75 citations

Combination chemotherapy: The interaction of methotrexate and 5-fluorouracil

1973 • 74 citations

Stimulatory effects of inosine and deoxyinosine on the incorporation of uracil-2-14-C, 5-fluorouracil-2-14-C, and 5-bromouracil-2-14-C into nucleic acids by Ehrlich ascites tumor cells in vitro.

1969 • 49 citations

Reactivation of dihydrofolate reductase inhibited by methotrexate or aminopterin

1977 • 43 citations

Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance

1980 • 43 citations

ACTIVE-SITE DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE

1971 • 42 citations

Adenosine metabolism in cultured lymphoid cells

1977 • 39 citations

Effects of nucleoside triphosphates on human ribonucleotide reductase from Molt-4F cells.

1979 • 38 citations

Enzyme pattern-directed chemotherapy

1979 • 31 citations

Kinetic simulation of anticancer drug interactions

1980 • 29 citations

Isolation of a homogeneous preparation of human thymidylate synthetase from HeLa cells

1980 • 26 citations

THE INFLUENCE OF CYTOSTATIC TREATMENT ON SERUM LDH PATTERNS OF PATIENTS WITH BRONCHIAL CARCINOMA AND ITS RELATION TO TUMOR REGRESSION

1968 • 23 citations

5-Substituted quinazoline antifolates

1980 • 20 citations