The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiae.

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

The Hydrophobic Effect: Formation of Micelles and Biological Membranes

1991 • 3,370 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

The Hydrophobic Effect: Formation of Micelles and Biological Membranes

1981 • 2,803 citations

Vectors for selective expression of cloned DNAs by T7 RNA polymerase

1987 • 1,449 citations

The molecular biology of the yeast saccharomyces: Life cycle and inheritance

1982 • 1,361 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

Bacteriorhodopsin and Related Pigments of Halobacteria

1982 • 767 citations

Methods in yeast genetics, laboratory manual

1987 • 733 citations

Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model

1985 • 732 citations

Easy identification of cDNA clones.

1983 • 587 citations

Isolation and nucleotide sequence of the gene encoding human rhodopsin.

1984 • 495 citations

Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein.

1987 • 439 citations

PROTEIN GLYCOSYLATION IN YEAST

1987 • 437 citations

The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway

1987 • 431 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

Identification of residues required for ligand binding to the beta-adrenergic receptor.

1987 • 398 citations

Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone.

1980 • 368 citations

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

1987 • 365 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

Nucleotide sequences of STE2 and STE3 , cell type-specific sterile genes from Saccharomyces cerevisiae

1985 • 351 citations

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1987 • 335 citations

Isolation and Genetic Analysis of Saccharomyces cerevisiae Mutants Supersensitive to G1 Arrest by a Factor and α Factor Pheromones

1982 • 322 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

The yeast α-factor receptor: structural properties deduced from the sequence of theSTE2gene

1985 • 318 citations

Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast

1981 • 302 citations

Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae.

1987 • 253 citations

Binding of α-factor pheromone to yeast a cells: Chemical and genetic evidence for an α-factor receptor

1983 • 211 citations

A yeast operator overlaps an upstream activation site

1987 • 200 citations

MUTATIONS AFFECTING SEXUAL CONJUGATION AND RELATED PROCESSES IN SACCHAROMYCES CEREVISIAE. II. GENETIC ANALYSIS OF NONMATING MUTANTS

1974 • 196 citations

Recovery of S. cerevisiae a cells from G1 arrest by α factor pheromone requires endopeptidase action

1979 • 193 citations

Cell Interactions and Regulation of Cell Type in the Yeast Saccharomyces Cerevisiae

1983 • 189 citations

Down regulation of the α-factor pheromone receptor in S. cerevisiae

1986 • 177 citations

Synchronization of haploid yeast cell cycles, a prelude to conjugation

1973 • 174 citations

Enhancement of immunoblot sensitivity by heating of hydrated filters

1986 • 168 citations

Two yeast mutants defective in endocytosis are defective in pheromone response

1986 • 164 citations

The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration

1987 • 142 citations

Yeast peptide pheromones, a-factor and α-factor, activate a common response mechanism in their target cells

1986 • 137 citations

Primary structural requirements for the enzymatic formation of the N-glycosidic bond in glycoproteins. Studies with alpha-lactalbumin

1978 • 124 citations

Morphogenic effects of alpha-factor on Saccharomyces cerevisiae a cells

1976 • 116 citations

A deletion that includes the signal peptidase cleavage site impairs processing, glycosylation, and secretion of cell surface yeast acid phosphatase.

1984 • 112 citations

Comparison of dose-response curves for alpha factor-induced cell division arrest, agglutination, and projection formation of yeast cells. Implication for the mechanism of alpha factor action.

1983 • 111 citations

Binding of alpha-factor pheromone to Saccharomyces cerevisiae a cells: dissociation constant and number of binding sites.

1986 • 108 citations

Yeast cells recover from mating pheromone alpha factor-induced division arrest by desensitization in the absence of alpha factor destruction.

1984 • 98 citations

Induction of the yeast α-specific STE3 gene by the peptide pheromone a-factor

1984 • 97 citations

Saccharomyces cerevisiae nuclear fusion requires prior activation by alpha factor.

1986 • 83 citations

Cell-Cell Recognition in Saccharomyces cerevisiae : Regulation of Mating-Specific Adhesion

1978 • 81 citations

Common signal transduction system shared by STE2 and STE3 in haploid cells of Saccharomyces cerevisiae : autocrine cell-cycle arrest results from forced expression of STE2

1987 • 80 citations

The Yeast Repeated Element Sigma Contains a Hormone-Inducible Promoter

1987 • 77 citations

Intramolecular disulfide bridges: avenues to receptor activation?

1987 • 59 citations

Molecular cloning of hormone-responsive genes from the yeast Saccharomyces cerevisiae.

1984 • 57 citations

Saccharomyces cerevisiae mutants unresponsive to alpha-factor pheromone: alpha-factor binding and extragenic suppression.

1987 • 49 citations

Structure-Activity Relationships of the Yeast α-Facto

1986 • 45 citations