New insights into cholangiocyte physiology

CFTR as a cAMP-Dependent Regulator of Sodium Channels

1995 • 1,074 citations

Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.

1993 • 761 citations

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1995 • 647 citations

Cytokines in intestinal inflammation: Pathophysiological and clinical considerations

1994 • 607 citations

Mechanisms and regulation of bile secretion

1991 • 402 citations

The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.

1994 • 354 citations

Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells

1993 • 347 citations

Regulation of Plasma Membrane Recycling by CFTR

1992 • 339 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas

1988 • 244 citations

Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents

1986 • 237 citations

Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides.

1996 • 225 citations

Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver

1996 • 224 citations

CFTR!

1992 • 192 citations

Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP

1996 • 184 citations

Regulation of membrane chloride currents in rat bile duct epithelial cells.

1993 • 181 citations

Regulation of Ion Channels by ABC Transporters That Secrete ATP

1995 • 174 citations

Recent advances in the isolation of liver cells

1994 • 172 citations

DETERMINANTS OF THE FLOW AND COMPOSITION OF BILE IN THE UNANESTHETIZED DOG DURING CONSTANT INFUSIONS OF SODIUM TAUROCHOLATE*

1960 • 171 citations

Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver

1994 • 165 citations

Integrative immunophysiology in the intestinal mucosa

1994 • 160 citations

Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro

1994 • 156 citations

Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism.

1992 • 151 citations

An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer.

1993 • 146 citations

Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells.

1996 • 140 citations

Na+-H+ exchange at the apical membrane of Necturus gallbladder. Extracellular and intracellular pH studies.

1982 • 136 citations

Hepatic Transport and Bile Secretion : Physiology and Pathophysiology

1992 • 136 citations

Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells.

1993 • 124 citations

Role of bile ducts during secretin choleresis in dogs

1966 • 124 citations

Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism.

1994 • 118 citations

Intracellular pH regulation in isolated rat bile duct epithelial cells.

1991 • 110 citations

Isolation of small polarized bile duct units.

1995 • 107 citations

Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes

1995 • 99 citations

Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes.

1994 • 99 citations

Hypertonic activation of AE2 anion exchanger in Xenopus oocytes via NHE-mediated intracellular alkalinization

1995 • 97 citations

Antibiotic-associated acute vanishing bile duct syndrome: A pattern associated with severe, prolonged, intrahepatic cholestasis

1994 • 96 citations

Adenosine nucleotides in bile

1996 • 94 citations

Secretin stimulates bile ductular secretory activity through the cAMP system

1992 • 87 citations

The stem cells of the liver ? a selective review

1992 • 85 citations

Adenosine triphosphate activates ion permeabilities in biliary epithelial cells

1994 • 85 citations

Secretin activates Cl- channels in bile duct epithelial cells through a cAMP-dependent mechanism

1994 • 82 citations

The Intrahepatic Biliary Epithelium: An Area of Growing Interest in Hepatology

1987 • 78 citations

Disappearing Intrahepatic Bile Ducts: The Syndromes and Their Mechanisms

1993 • 75 citations

Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts.

1993 • 70 citations

Na+-H+ exchange and Na+ entry across the apical membrane of Necturus gallbladder.

1984 • 65 citations

Cl− and K+ transport in human biliary cell lines

1993 • 62 citations

Na+-dependent and -independent Cl?/HCO3? exchange mediate cellular HCO3? transport in cultured human intrahepatic bile duct cells

1997 • 57 citations

GTP-binding proteins regulate high conductance anion channels in rat bile duct epithelial cells

1993 • 51 citations

Hypercholeresis induced by norchenodeoxycholate in biliary fistula rodent

1987 • 51 citations

Localization and characterization of secretin binding sites expressed by rat bile duct epithelium

1992 • 49 citations

Endothelin-1 secretion by human gallbladder epithelial cells in primary culture.

1993 • 49 citations

Expression of CFTR controls cAMP-dependent activation of epithelial K+ currents

1996 • 45 citations

Inhibition of the Cystic Fibrosis Transmembrane Conductance Regulator By ATP‐Sensitive K⁺ Channel Regulators^a

1993 • 44 citations

Isolation and culture of biliary epithelial cells.

1994 • 40 citations

Correction of the cystic fibrosis defect by gene complementation in human intrahepatic biliary epithelial cell lines

1995 • 40 citations

Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers

1991 • 38 citations

Characterization of high-conductance anion channels in rat bile duct epithelial cells

1992 • 36 citations

Secretin empties bile duct cell cytoplasm of vesicles when it initiates ductular HCO3− secretion in the pig

1988 • 35 citations

Hepatocellular Transport: Role of ATP-Binding Cassette Proteins

1996 • 33 citations

Bile acids in liver diseases

1997 • 28 citations

Drug elimination in chronic liver diseases

1997 • 28 citations

Electrolyte composition of the secretin fraction of bile from the perfused pig liver

1968 • 28 citations

Effect of ursodeoxycholic acid on intracellular pH in a bile duct epithelium-like cell line

1994 • 23 citations

Differential expression of Na+,H+-antiporter mRNA in biliary epithelial cells and in hepatocytes

1996 • 22 citations

Sodium, hydrogen antiporter activation by extracellular adenosine triphosphate in biliary epithelial cells

1996 • 21 citations

Molecular Strategies for Therapy of Cystic Fibrosis

1995 • 20 citations

Methods in Biliary Research

1994 • 17 citations

Pathobiology of biliary epithelia

1994 • 16 citations

Electrolyte transport in bile ductular epithelial cells.

1996 • 12 citations

Biliary epithelial cells: Innocent victims or active participants in immune-mediated liver disease?

1996 • 11 citations

Pathophysiology of the biliary epithelium

1997 • 7 citations

Vanishing bile duct syndrome : pathophysiology and treatment

1997 • 5 citations

Ion transporters that regulate intracellular pH and secretion in bile duct epithelial cells

1996 • 5 citations

Gene expression and polarized distribution of membrane acid/base carriers in a differentiated rat cholangiocyte cell line (NRC-1)

1997 • 1 citations

The use of isolated bile ductular epithelial cells in biliary physiology

1995 • 1 citations

Effects of bile acids on bile duct epithelial cells

1995 • 1 citations