K‐ras and p53 Alterations in Genomic DNA and Transcripts of Human Pancreatic Adenocarcinoma Cell Lines

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Pancreatic Carcinoma

1992 • 1,175 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 • 656 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.

1994 • 389 citations

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer

1991 • 375 citations

Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation.

1993 • 351 citations

Pancreatic adenocarcinomas frequently show p53 gene mutations.

1993 • 332 citations

Nuclear Accumulation of p53 Protein Is Mediated by Several Nuclear Localization Signals and Plays a Role in Tumorigenesis

1990 • 328 citations

A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.

1985 • 320 citations

Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.

1992 • 305 citations

p53 gene mutations and protein accumulation in human ovarian cancer.

1993 • 294 citations

Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation

1993 • 275 citations

Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.

1992 • 237 citations

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis.

1990 • 207 citations

S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues

1993 • 198 citations

p53 and K-RAS alterations in pancreatic epithelial cell lesions.

1993 • 186 citations

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes.

1992 • 171 citations

A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.

1984 • 158 citations

K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.

1992 • 123 citations

Amplification of protooncogenes in surgical specimens of human lung carcinomas

1990 • 121 citations

Base transitions are the most frequent genetic changes at P53 in gastric cancer.

1993 • 105 citations

Frequent Glycine‐to‐Aspartic Acid Mutations at Codon 12 of c‐Ki‐ras Gene in Human Pancreatic Cancer in Japanese

1990 • 102 citations

Biology of pancreatic cancer.

1991 • 98 citations

Expression of multidrug resistance gene and localization of P-glycoprotein in human primary ovarian cancer.

1994 • 73 citations

K‐ras Gene Mutation in Early Ductal Lesions Induced in a Rapid Production Model for Pancreatic Carcinomas in Syrian Hamsters

1993 • 59 citations

Mutational activation of the c-K-ras gene in human pancreatic carcinoma

1990 • 54 citations

Characterization of new human pancreatic cancer cell lines which propagate in a protein-free chemically defined medium.

1990 • 48 citations

Association of Ki-ras with amplified DNA sequences, detected in human ovarian carcinomas by a modified in-gel renaturation assay.

1989 • 44 citations

Point mutation of the p53 gene resulting in splicing inhibition in small cell lung carcinoma

1990 • 34 citations

Splicing mutations of the p53 gene in human hepatocellular carcinoma.

1993 • 32 citations

Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas

1991 • 9 citations

Structural alterations of the p53 gene in human leukemias

1992 • 8 citations