K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

1989 • 1,295 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

[31] Detection and localization of single base changes by denaturing gradient gel electrophoresis

1987 • 944 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer

1991 • 375 citations

Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation.

1993 • 351 citations

High frequency of Ki‐ras codon 12 mutations in pancreatic adenocarcinomas

1989 • 295 citations

Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.

1987 • 230 citations

Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer.

1986 • 192 citations

p53 and K-RAS alterations in pancreatic epithelial cell lesions.

1993 • 186 citations

Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation.

1993 • 184 citations

The c‐erbB‐2 proto‐oncogene in human pancreatic cancer

1990 • 172 citations

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes.

1992 • 171 citations

Polymorphism at codon 213 within the p53 gene.

1991 • 137 citations

Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas.

1990 • 132 citations

Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma.

1992 • 126 citations

Epidemiology of pancreas cancer (1988)

1989 • 113 citations

Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism.

1992 • 110 citations

Base transitions are the most frequent genetic changes at P53 in gastric cancer.

1993 • 105 citations

Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells.

1993 • 103 citations

Biology of pancreatic cancer.

1991 • 98 citations

The erbB‐3 Gene in human pancreatic cancer

1992 • 92 citations

Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.

1991 • 90 citations

Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer.

1992 • 33 citations