Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Reshaping human antibodies for therapy

1988 • 1,555 citations

Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response

1997 • 1,536 citations

Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells

1999 • 1,218 citations

Pro‐inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum‐free conditions

1997 • 1,179 citations

CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.

1996 • 962 citations

Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.

1995 • 756 citations

The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation

2000 • 702 citations

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

1996 • 696 citations

Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells

2000 • 560 citations

Acute graft-versus-host disease does not require alloantigen expression on host epithelium

2002 • 534 citations

In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation

2000 • 525 citations

Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application

1999 • 499 citations

Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells

2000 • 483 citations

CD34+ Hematopoietic Progenitors From Human Cord Blood Differentiate Along Two Independent Dendritic Cell Pathways in Response to Granulocyte-Macrophage Colony-Stimulating Factor Plus Tumor Necrosis Factor α: II. Functional Analysis

1997 • 442 citations

Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype

1989 • 356 citations

Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen

2002 • 355 citations

Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha.

1995 • 350 citations

TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors.

1996 • 312 citations

Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha.

1995 • 296 citations

LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation

2001 • 288 citations

Prostaglandin E2 and Tumor Necrosis Factor α Cooperate to Activate Human Dendritic Cells: Synergistic Activation of Interleukin 12 Production

1997 • 281 citations

Dendritic Cells

1999 • 269 citations

Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate

1996 • 235 citations

Effect of Campath-1H antibody on human hematopoietic progenitors in vitro

1993 • 213 citations

Inhibition of human macrophage colony formation by interleukin 4.

1989 • 173 citations

Characterization of the CAMPATH‐1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone

1991 • 167 citations

Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution

2002 • 144 citations

Campath-1H monoclonal antibody therapy

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Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen

1993 • 111 citations

Large-Scale Culture and Selective Maturation of Human Langerhans Cells from Granulocyte Colony-Stimulating Factor-Mobilized CD34+ Progenitors

2000 • 108 citations

Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation of normal human T lymphocytes

1995 • 97 citations

Monoclonal antibody therapy of cancer.

1999 • 96 citations

Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease

2002 • 92 citations

Pharmacokinetics of CAMPATH-1H: assay development and validation

2002 • 84 citations

Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease

2002 • 82 citations

A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans

1996 • 80 citations

THE REPOPULATION CAPACITY OF BONE MARROW GRAFTS FOLLOWING PRETREATMENT WITH MONOCLONAL ANTIBODIES AGAINST T LYMPHOCYTES IN RHESUS MONKEYS

1988 • 43 citations

CD34+ Hematopoietic Progenitors From Human Cord Blood Differentiate Along Two Independent Dendritic Cell Pathways in Response to Granulocyte-Macrophage Colony-Stimulating Factor Plus Tumor Necrosis Factor α: II. Functional Analysis

1997 • 39 citations

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