Clinical pharmacokinetics of antiepileptic drugs in adults

Advances in biochemical psychopharmacology

1970 • 1,186 citations

The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

1975 • 693 citations

Advances in epileptology

1990 • 543 citations

Clinical Pharmacokinetics of Diazepam

1978 • 490 citations

Sodium Valproate

1977 • 318 citations

Therapeutic Drug Monitoring in Saliva

1978 • 300 citations

Protein Binding of Diphenylhydantoin and Desmethylimipramine in Plasma from Patients with Poor Renal Function

1971 • 296 citations

Chronic Antiepileptic Toxicity: A Review

1975 • 286 citations

Influence of Food on the Bioavailability of Drugs

1978 • 277 citations

Protein Binding and Kinetics of Drugs in Liver Diseases

1977 • 262 citations

Pharmacokinetic Profile of Diazepam in Man following Single Intravenous and Oral and Chronic Oral Administrations

1973 • 257 citations

Diphenylhydantoin Metabolism, Blood Levels, and Toxicity

1964 • 250 citations

SERUM-PHENYTOIN

1976 • 237 citations

Metabolism of diazepam in rat, dog, and man.

1965 • 229 citations

The Distribution and Excretion of Phenobarbital1

1957 • 225 citations

The rate of decline of diphenylhydantoin in human plasma

1970 • 213 citations

Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.

1976 • 211 citations

Altered Hepatic Blood Flow and Drug Disposition1

1976 • 209 citations

Pharmacokinetics and bioavailability of sodium valproate

1977 • 204 citations

Blood Level Distribution Patterns of Diazepam and its Major Metabolite in Man

1966 • 202 citations

[Clinical pharmacokinetics of carbamazepine].

1989 • 193 citations

Plasma kinetics of carbamazepine and its epoxide metabolite in man after single and multiple doses

1975 • 187 citations

SERUM-PHENYTOIN LEVELS IN MANAGEMENT OF EPILEPSY

1975 • 187 citations

Carbamazepine for epilepsy

1974 • 185 citations

Anticonvulsant Effect of Diphenylhydantoin Relative to Plasma Levels

1974 • 184 citations

Clonazepam

1976 • 178 citations

Subnormal Serum Folate and Macrocytosis Associated with Anticonvulsant Drug Therapy

1964 • 177 citations

Diazepam metabolism in normal man. I. Serum concentrations and clinical effects after intravenous, intramuscular, and oral administration.

1974 • 175 citations

Usefulness of Blood Levels of Antiepileptic Drugs

1974 • 173 citations

One drug for epilepsy.

1978 • 163 citations

Plasma protein binding of diphenylhydantoin Effects of sex hormones, renal and hepatic disease

1974 • 159 citations

Intravenous phenytoin

1978 • 153 citations

Drug concentration in saliva

1978 • 153 citations

The metabolic conversion of 5, 5-diphenyl hydantoin to 5-(p-hydroxyphenyl)-5-phenyl hydantoin.

1957 • 151 citations

Clinical Pharmacokinetics of Anticonvulsants

1976 • 150 citations

Clinical Pharmacology of Anti-Epileptic Drugs

1975 • 148 citations

Diazepam metabolism in normal man

1974 • 146 citations

Pharmacokinetics of di-n-propylacetate in epileptic patients

1975 • 142 citations

Drug Kinetics in Pregnancy

1977 • 138 citations

Epilepsy. The eighth international symposium

1978 • 138 citations

Pharmacokinetics of carbamazepine in normal man

1975 • 137 citations

THE PRESENT STATUS OF PSYCHOTROPIC DRUGS

1966 • 137 citations

Plasma Levels of Diazepam After Parenteral and Rectal Administration in Children

1975 • 136 citations

Neuro-Psychopharmacology

1978 • 133 citations

Pharmacokinetics in Patients with Cardiac Failure

1976 • 131 citations

The clinical pharmacokinetics of phenytoin

1977 • 129 citations

PLASMA‐DIAZEPAM IN INFANTS AFTER RECTAL ADMINISTRATION IN SOLUTION AND BY SUPPOSITORY

1977 • 128 citations

Serum protein binding and pharmacokinetics of valproate in man, dog, rat and mouse.

1978 • 128 citations

Ethosuximide in the treatment of absence (petit mal) seizures

1975 • 126 citations

Valproic acid in epilepsy: Clinical and pharmacological effects

1978 • 125 citations

Kinetics of diphenylhydantoin in uraemic patients: Consequences of decreased plasma protein binding

1974 • 124 citations

Salivary levels of anticonvulsants

1977 • 121 citations

Disposition of valproic acid in man

1977 • 121 citations

Efficacy of intravenous phenytoin in the treatment of status epilepticus: Kinetics of central nervous system penetration

1977 • 120 citations

Diphenylhydantoin Metabolism in Uremia

1971 • 120 citations

Serum clonazepam concentrations in children with absence seizures

1975 • 120 citations

Diazepam elimination in premature and full term infants, and children

1973 • 116 citations

Placental transfer of diazepam and its disposition in the newborn

1975 • 116 citations

Paradoxical Intoxication,:A Complication of Anticonvulsant Administration

1975 • 113 citations

DELAYED RECOVERY FROM A SEDATIVE: CORRELATION OF THE PLASMA LEVELS OF DIAZEPAM WITH CLINICAL EFFECTS AFTER ORAL AND INTRAVENOUS ADMINISTRATION

1972 • 111 citations

Individualization of phenytoin dosage regimens

1977 • 108 citations

Disposition of sodium valproate in epileptic patients.

1978 • 108 citations

Time‐course of interaction between carbamazepine and clonazepam in normal man

1978 • 107 citations

Phenobarbital: studies of elimination, accumulation, tolerance, and dosage schedules.

1954 • 106 citations

Clonazepam

1976 • 106 citations

Reduction of absorption of digoxin, phenytoin and aspirin by activated charcoal in man

1978 • 105 citations

INTERACTION BETWEEN PHENOBARBITAL AND DIPHENYLHYDANTOIN IN ANIMALS AND IN EPILEPTIC PATIENTS*

1971 • 104 citations

INFLUENCE OF PHENOBARBITAL AND DIPHENYLHYDANTOIN ON PLASMA CARBAMAZEPINE LEVELS IN PATIENTS WITH EPILEPSY

2009 • 104 citations

Antiepileptic drugs: quantitative analysis and interpretation

1978 • 102 citations

Plasma protein binding of valproic acid in healthy subjects and in patients with renal disease.

1978 • 102 citations

Determination of bioavailability of diazepam in various formulations from steady state plasma concentration data

1972 • 101 citations

Plasma anticonvulsant concentrations during pregnancy

1977 • 98 citations

Drug Metabolism and Pharmacokinetics in Malnutrition

1978 • 98 citations

Valproate Sodium: A Controlled Clinical Trial Including Monitoring of Drug Levels

1977 • 96 citations

The metabolic hydroxylation of phenobarbital.

1956 • 94 citations

Anticonvulsant Drugs in Human Epileptogenic Brain

1973 • 93 citations

Plasma diazepam levels after single dose oral and intramuscular administration

1975 • 93 citations

Carbamazepine: Placental Transport, Tissue Concentrations in Foetus and Newborn, and Level in Milk

1977 • 93 citations

Human brain, cerebrospinal fluid, and plasma concentrations of diphenylhydantoin and phenobarbital

1974 • 92 citations

Diazepam metabolism in normal man. II. Serum concentration and clinical effect after oral administration and cumulation.

1974 • 92 citations

Plasma protein binding of carbamazepine

1975 • 91 citations

Plasma Drug Level Monitoring in Pregnancy

1977 • 91 citations

PHENYTOIN and PHENOBARBITONE PLASMA CLEARANCE DURING PREGNANCY

1976 • 89 citations

PHARMACOKINETICS OF VALPROIC ACID AFTER ORAL AND INTRAVENOUS ADMINISTRATION

1978 • 88 citations

Concentration of Dipropylacetate in Plasma

1975 • 87 citations

Improved Control of Epilepsy by Monitoring Plasma Ethosuximide

1973 • 87 citations

Diphenylhydantoin, Phenobarbital, and Primidone in Saliva, Plasma, and Cerebrospinal Fluid

1975 • 87 citations

Pharmacokinetics and side-effects of clonazepam and its 7- amino-metabolite in man

1975 • 87 citations

Distribution of valproate across the interface between blood and cerebrospinal fluid

1978 • 86 citations

Disposition of valproic acid in patients with liver disease

1978 • 86 citations

Diphenylhydantoin and Phenobarbital Toxicity

1964 • 85 citations

DIAZEPAM AND BREAST-FEEDING

1972 • 85 citations

Anticonvulsant Level in Saliva, Serum, and Cerebrospinal Fluid

1975 • 85 citations

Epoxides metabolically produced from some known carcinogens and from some clinically used drugs. I. Differences in mutagenicity

1975 • 84 citations

Diazepam absorption: Effect of antacids and food

1978 • 84 citations

Distribution and elimination kinetics of carbamazepine in man

1975 • 84 citations

SALIVARY PHENYTOIN CONCENTRATIONS IN EPILEPSY AND IN CHRONIC RENAL FAILURE

1976 • 83 citations

Aspects of the Pharmacology of Phenytoin (Dilantin®) and Phenobarbital Relevant to their Dosage in the Treatment of Epilepsy

1959 • 83 citations

Human Epileptic Brain

1975 • 83 citations

Mass Spectrometric Characterization of Carbamazepine-10,11-epoxide,a Carbamazepine Metabolite Isolated from Human Urine

1972 • 82 citations

Effect of dosage increments on blood phenytoin concentrations

1972 • 81 citations

Epileptic Seizures - Behavior - Pain

1977 • 81 citations

Plasma Levels and Urinary Excretion of Three Barbituric Acids after Oral Administration to Man.*)

1954 • 81 citations

Diphenylhydantoin Concentrations in Saliva

1974 • 80 citations

Drug Protein Binding and the Nephrotic Syndrome

1976 • 78 citations

Brain concentrations of phenytoin, phenobarbitone and primidone in epileptic patients

1975 • 78 citations

Pharmacokinetic Profiles of Clonazepam in Dog and Humans and of Flunitrazepam in Dog

1974 • 78 citations

Epileptic Seizures--Behaviour--Pain

1977 • 77 citations

Serum Concentrations of Diazepam in Subjects With Epilepsy

1973 • 73 citations

Carbamazepine as a single drug in the treatment of epilepsy. A prospective study of serum levels and seizure control.

1978 • 73 citations

Carbamazepine and its 10,11-epoxide in children and adults with epilepsy

1977 • 73 citations

Pharmacokinetics of the anticonvulsant drug clonazepam evaluated from single oral and intravenous doses and by repeated oral administration

1975 • 72 citations

Plasma Protein Binding of Diazepam and Tolbutamide in Chronic Alcoholics

1976 • 71 citations

Diazepam and active metabolite in breast milk and their transfer to the neonate.

1975 • 71 citations

Clinical Pharmacology

1979 • 71 citations

Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients.

1975 • 70 citations

Optimal phenytoin therapy: A new technique for individualizing dosage

1978 • 70 citations

Water intoxication in epileptic patients receiving carbamazepine.

1978 • 70 citations

Diazepam metabolism in normal man

1974 • 70 citations

Plasma concentrations of benzodiazepines.

1977 • 69 citations

Hyponatraemia during carbamazepine treatment.

1977 • 69 citations

Impaired plasma protein binding of phenytoin in uremia and displacement effect of salicylic acid

1976 • 67 citations

The concentrations of diazepam and its metabolites in the plasma after an acute and chronic administration

1974 • 67 citations

Anticonvulsant Therapy. Pharmacological Basis and Practice

1981 • 67 citations

Metabolism and Pharmacokinetics of Carbamazepine

1975 • 67 citations

Plasma Level Monitoring of Anticonvulsants

1976 • 67 citations

Drug disposition during development

1978 • 67 citations

CSF CONCENTRATIONS AND SERUM PROTEIN BINDING OF CARBAMAZEPINE AND CARBAMAZEPINE‐10, 11‐EPOXIDE IN EPILEPTIC PATIENTS

1976 • 66 citations

Influence of acute viral hepatitis on phenytoin kinetics and protein binding

1975 • 66 citations

Interactions of Antiepileptic Drugs

1975 • 64 citations

PHENYTOIN DOSE ADJUSTMENT IN EPILEPTIC PATIENTS

1974 • 64 citations

Status epilepticus in pregnancy

1978 • 64 citations

Valproic acid Interaction with other anticonvulsant drugs

1978 • 63 citations

Pharmacokinetics of diazepam in disordered liver function

1976 • 63 citations

Cerebrospinal‐Fluid Concentrations of Diazepam and its Metabolites in Man

1975 • 63 citations

Plasma protein binding interaction between phenytoin and valproic acid in vitro.

1978 • 62 citations

Plasma concentrations of diazepam and of its metabolite N‐desmethyldiazepam in relation to anxiolytic effect

1974 • 62 citations

Pharmacokinetic Model to Describe Self‐Induced Decreases in Steady‐State Concentrations of Carbamazepine

1976 • 62 citations

PLASMA PROTEIN BINDING OF PHENYTOIN AFTER CHOLECYSTECTOMY AND NEUROSURGICAL OPERATIONS

1977 • 62 citations

Pharmacokinetics of carbamazepine in normal humans after single and repeated oral doses

1976 • 62 citations

Factors influencing plasma phenobarbitone levels in epileptic patients.

1977 • 61 citations

DRUG TREATMENT OF EPILEPSY

1976 • 60 citations

Effects of different rates of absorption of two benzodiazepins on subjective and objective parameters

1974 • 59 citations

Carbamazepine plasma and tissue levels in the rat

1971 • 59 citations

Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy

1976 • 59 citations

Clinical Pharmacological Aspects of Valproate Sodium

1977 • 59 citations

SODIUM VALPROATE IN the TREATMENT of RESISTANT EPILEPSY

1976 • 59 citations

Clinical significance of generic inequivalence of three different pharmaceutical preparations of phenytoin

1974 • 58 citations

Quantitative determination of carbamazepine in plasma by mass fragmentography

1973 • 58 citations

Absorption and Distribution of Antiepileptic Drugs

1975 • 57 citations

A Comparative Controlled Study Between Carbamazepine and Diphenylhydantoin in Psychomotor Epilepsy

1976 • 57 citations

Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration

1972 • 56 citations

Water intoxication during carbamazepine treatment.

1973 • 55 citations

Carbamazepine and carbamazepine‐10, 11‐epoxide concentrations in human brain.

1977 • 55 citations

Accumulation of Phenobarbital in Man

1963 • 55 citations

Plasma concentration of diazepam and N-desmethyldiazepam in children after a single rectal or intramuscular dose of diazepam

1978 • 55 citations

Methods of Analysis of Antiepileptic Drugs

1974 • 54 citations

Sodium valproate in the treatment of intractable seizure disorders

1978 • 54 citations

RATE OF ELIMINATION OF TRACER DOSES OF PHENYTOIN AT DIFFERENT STEADY‐STATE SERUM PHENYTOIN CONCENTRATIONS IN EPILEPTIC PATIENTS

1974 • 54 citations

THE METABOLIC CONVERSION OF PRIMIDONE (MYSOLINE®) TO PHENOBARBITONE IN PATIENTS UNDER LONG-TERM TREATMENT

1967 • 54 citations

Pharmacokinetic Data of Carbamazepine and Its Major Metabolites in Man

1975 • 54 citations

Interaction of chloramphenicol with phenytoin and phenobarbital; Case report

1978 • 53 citations

CLONAZEPAM IN THE TREATMENT OF EPILEPSY

1974 • 53 citations

A Clinical Study of Serum Primidone Levels

1970 • 52 citations

Bioavailability of phenytoin in lipid containing dosage forms in rats

1978 • 52 citations

Further observations on carbamazepine plasma levels in epileptic patients

1976 • 52 citations

Water intoxication due to carbamazepine.

1977 • 52 citations

A Simple Method for Determining Diazepam and Its Major Metabolites in Biological Fluids: Application in Bioavailability Studies

1975 • 51 citations

Steady‐state kinetics of valproic acid in epileptic patients

1978 • 51 citations

Primidone, diphenylhydantoin and phenobarbital

1973 • 51 citations

Studies on plasma protein binding of carbamazepine

1974 • 50 citations

Interactions with Antiepileptic Drugs

1977 • 49 citations

The pharmacokinetics of carbamazepine

1977 • 49 citations

Pharmacokinetic Studies on Carbamazepine in Volunteers and in Epileptic Patients

1975 • 48 citations

Pulmonary Disease and Drug Kinetics

1978 • 48 citations

Passage of diazepam and desmethyldiazepam into breast milk.

1976 • 48 citations

Relationships between serum and cerebrospinal fluid anticonvulsant drug and folic acid concentrations in epileptic patients

1972 • 48 citations

Effects of Age, Sex, Obesity, and Pregnancy on Plasma Diphenylhydantoin Levels

1974 • 47 citations

ABSORPTION AND SEDATIVE EFFECTS OF DIAZEPAM AFTER ORAL ADMINISTRATION AND INTRAMUSCULAR ADMINISTRATION INTO THE VASTUS LATERALIS MUSCLE AND THE DELTOID MUSCLE

1975 • 47 citations

Diazepam concentrations in parotid saliva, mixed saliva, and plasma

1978 • 47 citations

Absorption and Elimination of Ethosuximide In Children

1969 • 46 citations

Antiepileptic Drugs: Biotransformation, Metabolism, and Serum Half‐Life

1975 • 46 citations

Polyethylene Glycol as a Solvent for Diazepam: Bioavailability and Clinical Effects after Intramuscular Administration, Comparison of Oral, Intramuscular and Rectal Administration, and Precipitation from Intravenous Solutions

1976 • 46 citations

Precipitation of Diazepam From Intravenous Preparations

1973 • 46 citations

Intramuscular administration of phenytoin

1966 • 45 citations

Drug treatment of epilepsy

1994 • 44 citations

The Effect of Dialysis on the Protein Binding of Drugs in the Plasma of Patients with Acute Renal Failure

1974 • 44 citations

Identification of Metabolites of Valproic Acid in Serum of Humans, Dog, Rat, and Mouse

1978 • 44 citations

Interaction between phenytoin and imipramine.

1977 • 43 citations

PLASMA LEVEL AND EFFECT OF CARBAMAZEPINE IN GRAND MAL AND PSYCHOMOTOR EPILEPSY

1975 • 42 citations

Quantitative determination of clonazepam and its metabolites in human plasma by gas chromatography

1974 • 41 citations

Two-Fold Interindividual Variation in Plasma Protein Binding of Phenytoin in Patients with Epilepsy

1976 • 41 citations

A Study of the Pharmacokinetics of Phenytoin (Diphenylhydantoin) in Epileptic Patients, and the Development of a Nomogram for Making Dose Increments

1975 • 41 citations

Ethosuximide Pharmacokinetics in a Pregnant Patient and Her Newborn

1978 • 41 citations

Carbamazepine pharmacokinetics in young, adult and pregnant rats. Relation to pharmacological effects.

1976 • 41 citations

[New drugs. 7].

1971 • 40 citations

Blood Serum and Cerebrospinal Fluid Levels and Renal Clearance of Phenemal*) in Treated Epileptics**).

1954 • 39 citations

Detection of 5-(3, 4-Dihydroxy-1, 5-Cyclohexadien-1-Yl) -5-Phenylsydantoin as a Major Metabolite of 5, 5-Diphenylhydantoin (Dilantin) in the Newborn Human

1971 • 38 citations

Bioavailability of 11 phenytoin products

1977 • 38 citations

Removal of Phenytoin by Hemodialysis in Uremic Patients

1977 • 38 citations

Brain concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients

1978 • 38 citations

ASSAY AND PHARMACOKINETICS OF CLONAZEPAM IN HUMANS

2009 • 37 citations

INTERACTION BETWEEN CARBAMAZEPINE AND PROPOXYPHENE IN MAN

2009 • 37 citations

Parotid and whole saliva in the prediction of serum total and free phenytoin concentrations

1978 • 37 citations

Acute Diphenylhydantoin Intoxication

1968 • 37 citations

Clinical Pharmacy and Clinical Pharmacology

1977 • 37 citations

Concentration of Carbamazepine (Tegretol®) in Serum and in Cerebrospinal Fluid in Patients with Epilepsy

1973 • 37 citations

Factors influencing diazepam pharmacokinetics: age, sex, and liver disease.

1978 • 35 citations

Phenytoin concentrations in mixed, parotid and submandibular saliva and serum measured by radioimmunoassay.

1977 • 35 citations

Intoxication Caused by Interaction of Chloramphenicol and Phenytoin

1977 • 34 citations

Metabolism of Valproate Sodium in Rabbit, Rat, Dog, and Man

1977 • 34 citations

Frequency distribution of free warfarin and free phenytoin fraction values in serum of healthy human adults

1977 • 34 citations

Drug distribution in renal failure

1977 • 33 citations

The renal handling of diphenylhydantoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin

1973 • 33 citations

Bioavailability of Two Carbamazepine Preparations During Chronic Administration to Epileptic Patients

1975 • 33 citations

ELEVATION OF DIPHENYLHYDANTOIN and PRIMIDONE SERUM CONCENTRATION BY ADDITION OF DIPROPYLACETATE, A NEW ANTICONVULSANT DRUG

1975 • 33 citations

Bioavailability of four brands of phenytoin tablets

1975 • 32 citations

Effeets of folie aeid on phenytoin kineties in healthy subjeets

1978 • 32 citations

Use of saliva in monitoring carbamazepine medication in epileptic children

1977 • 32 citations

Compatibility and Stability of Diazepam Injection Following Dilution with Intravenous Fluids

1978 • 31 citations

PHENOBARBITAL METABOLISM IN ADULTS AND IN NEWBORN INFANTS

1978 • 31 citations

Plasma diphenylhydantoin levels after loading and maintenance doses

1973 • 31 citations

Carbamazepine as an anticonvulsant

1974 • 31 citations

The absorption and excretion of ethosuximide.

1973 • 30 citations

10,11-Dihydro-10,11-dihydroxy-5H-dibenz[b,f]azepine-5-carboxamide, a metabolite of carbamazepine isolated from human and rat urine

1973 • 30 citations

Intoxication with 5,5-diphenylhydantoin (Dilantin)

1972 • 30 citations

Excretion of Valproic Acid into Semen of Rabbits and Man

1978 • 30 citations

Interaction between phenytoin and antacids.

1978 • 29 citations

A method for shifting from oral to intramuscular diphenylhydantoin administration

1974 • 29 citations

A Case Report and Review of the Literature

1978 • 29 citations

Carbamazepine: biotransformation.

1975 • 29 citations

The Pharmacokinetics of Carbamazepine in Plasma and Saliva of Man

1977 • 28 citations

Drug administration in renal failure

1977 • 28 citations

Interaction of phenytoin and primidone.

1975 • 28 citations

Pharmacokinetics of Carbamazepine in Monkeys following Intravenous and Oral Administration

1975 • 28 citations

Studies on the Absorption Rate of Barbiturates in Man

1965 • 27 citations

Quantitation of phenobarbital and its main metabolites in human urine

1975 • 27 citations

THE EFFECT OF ANTICONVULSANT DRUGS WHICH INDUCE LIVER MICROSOMAL ENZYMES ON DERIVED AND INGESTED PHENOBARBITONE LEVELS

2009 • 27 citations

PLASMA-DIAZEPAM LEVELS FOLLOWING INTRAMUSCULAR INJECTION BY NURSES AND DOCTORS

1974 • 27 citations

CARBAMAZEPINE (TEGRETOL) AS AN ANTICONVULSANT A CONTROLLED DOUBLE-BLIND COMPARISON WITH DIPHENYLHYDANTOIN (DILANTIN)

1975 • 26 citations

PLASMA LEVELS OF DIAZEPAM AND ITS MAJOR METABOLITE FOLLOWING INTRAMUSCULAR ADMINISTRATION

1973 • 26 citations

TEGRETOL IN TRIGEMINAL NEURALGIA WITH SPECIAL REFERENCE TO HEMATOPOIETIC SIDE EFFECTS

1969 • 25 citations

THERAPEUTIC AND PHARMACOKINETIC EFFECTS OF INCREASING PHENYTOIN IN CHRONIC EPILEPTICS ON MULTIPLE DRUG THERAPY

1976 • 25 citations

On the distribution of drugs in saliva and blood plasma.

1977 • 25 citations

Acetazolamide-Induced Interference With Primidone Absorption

1977 • 25 citations

Bioavailability of Four Different Pharmaceutical Preparations of Carbamazepine

1978 • 25 citations

Biliary elimination of diazepam in man

1976 • 25 citations

Clonazepam Overdose Resulting in Cyclic Coma

1977 • 24 citations

Plasma concentrations of 5‐(4‐hydroxyphenyl)‐5‐phenylhydantoin in phenytoin‐treated patients

1977 • 24 citations

Loading and conventional dose therapy with phenytoin in children: Kinetic profile of parent drug and main metabolite in plasma

1976 • 24 citations

Effects of Renal Disease upon Drug Disposition

1978 • 24 citations

Distribution of Anticonvulsant Drugs in Gray and White Matter of Human Brain

1977 • 23 citations

Identification of 5-(3,4-Dihydroxyphenyl)-5-Phenylhydantoin as a Metabolite of 5,5-DiphenyIhydantoin (Phenytoin) in Rats and Man

1972 • 23 citations

Is phenytoin metabolism dose‐dependent by enzyme saturation or by feedback inhibition?

1978 • 22 citations

Factors affecting the bioavailability of phenytoin.

1977 • 21 citations

Greater reliability of tear versus saliva anticonvulsant levels

1978 • 21 citations

Diphenylhydantoin: Its Use in Detecting Early Insulin Secretory Defects in Patients with Mild Glucose Intolerance

1973 • 20 citations

Plasma levels of di-no-propylacetate and clonazepam in epileptic patients.

1977 • 20 citations

Metabolite pattern of valproic acid. Part I: gaschromatographic determination of the valproic acid metabolite artifacts, heptanone-3, 4- and 5-hydroxyvalproic acid lactone.

1978 • 20 citations

Neurotoxicity of carbamazepine.

1975 • 20 citations

Preliminary observations on valproic acid kinetics in patients with epilepsy.

1977 • 20 citations

Detection of a 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-metabolite of phenobarbital and mephobarbital in rat, guinea pig and human.

1972 • 20 citations

Antiepileptic drug monitoring

1978 • 19 citations

Metabolism of ethosuximide

1976 • 19 citations

A Preliminary Study of Serum Carbamazepine Levels in Healthy Subjects and in Patients with Epilepsy

1975 • 18 citations

Anticonvulsant Therapy: Pharmacological Basis and Practice

1975 • 18 citations

Clinical pharmacology of anti-epileptic drugs: a summary of current information.

1977 • 17 citations

Drug Interaction in Epileptic Patients

1975 • 17 citations

[Rapid method of quantitative analysis of sodium dipropylacetate in serum or plasma].

1973 • 17 citations

Bioavailability of three phenytoin preparations in healthy subjects and in epileptics

1977 • 17 citations

Inhibition of phenytoin metabolism by other drugs used in epilepsy.

1975 • 17 citations

Distribution of pentobarbital and diphenylhydantoin between plasma and cells in blood: Effect of salicylic acid, temperature and total drug concentration

1977 • 16 citations

Identification of Urinary Catechol and Methylated Catechol Metabolites of Phenytoin in Humans, Monkeys, and Dogs by GLC and GLC-Mass Spectrometry

1977 • 16 citations

PHENYTOIN DOSAGE IN THE ELDERLY

1977 • 16 citations

Phenytoin intoxication during concurrent diazepam therapy

1977 • 16 citations

Use of phenytoin serum levels in a case of status epilepticus

1976 • 16 citations

Clinical Relevance of the Effect of Hepatic Disease on Drug Disposition

1978 • 16 citations

Correlation between red cell and free plasma phenytoin levels in renal disease

1976 • 15 citations

Serum carbamazepine concentration and clinical control.

1975 • 15 citations

Pharmacokinetic studies with valproic acid in man.

1977 • 15 citations

Regional distribution of diazepam and its metabolites in the brain of cat after chronic treatment

1976 • 15 citations

Unaltered Metabolism of Phenytoin in Thyroid Disorders

1978 • 15 citations

Quantitative Underwater Study of Benthic Communities Inhabiting Kelp Beds off California

1956 • 14 citations

Pharmacokinetics of Clonazepam in Man and Laboratory Animals

1975 • 13 citations

EFFECT OF DIPHENYLHYDANTOIN ON PLASMA-INSULIN IN INSULINOMA

1973 • 13 citations

The bioavailability of phenytoin

1977 • 13 citations

Oral and intramuscular phenytoin

1976 • 13 citations

Klinische Pharmakokinetik von Diazepam und seinen biologisch aktiven Metaboliten

1978 • 13 citations

LACK OF EFFECT OF CLONAZEPAM, ON SERUM LEVELS OF DIPHENYLHYDANTOIN, PHENOBARBITAL AND CARBAMAZEPINE

1977 • 13 citations

Drug Estimation in the Treatment of Epilepsy

1974 • 13 citations

Ethosuximide Blood Levels in Epileptics

1970 • 12 citations

Ethosuximide dosage regimens

1976 • 12 citations

Excretion of Phenobarbitone in Urine after Intake of Large Doses

1969 • 12 citations

DIAZEPAM: INTRAVENOUS INFUSION IN the TREATMENT of STATUS EPILEPTICUS

1976 • 12 citations

ABSORPTION AND ELIMINATION OF ZARONTIN.

1964 • 12 citations

SALIVARY CONCENTRATIONS OF ANTIEPILEPTIC DRUGS

1976 • 11 citations

CHRONIC PHENYTOIN THERAPY AND CARBOHYDRATE TOLERANCE

1973 • 11 citations

Phenytoin overdose. Kinetics.

1978 • 11 citations

Diphenylhydantoin toxicity

1974 • 10 citations

Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy.

1978 • 9 citations

Urinary Excretion of Phenobarbital in a Neonate Having Withdrawal Symptoms

1977 • 9 citations

Removal of phenytoin by hemodialysis in uremic patients

1977 • 9 citations

Influences on the Absorption of Diphenylhydantoin Preparations¹

1978 • 8 citations

Precipitation of diazepam from intravenous preparations

1973 • 8 citations

Enteric Coated Dipropylacetate (Depakine®)

1975 • 8 citations

CLINICAL SIGNIFICANCE OF MONITORING PLASMA LEVELS OF BENZODIAZEPINE TRANQUILIZERS AND ANTIEPILEPTIC DRUGS

1978 • 8 citations

Plasmakonzentrationen nach Injektion und Infusion von Phenytoin

1977 • 7 citations

THE EFFECTS OF TOXIC AND NON-TOXIC SERUM PHENYTOIN LEVELS ON CARBOHYDRATE TOLERANCE AND INSULIN LEVELS

2009 • 6 citations

Gas chromatographic-mass spectrometric studies on carbamazepine.

1973 • 6 citations

Plasma Levels of Phenobarbital and Phenytoin in Epileptic Outpatients

1977 • 6 citations

Carbamazepine for epilepsy

1967 • 6 citations

Plasma level studies on different brands of sodium diphenylhydantoin (DPH) and primidone.

1975 • 5 citations

Intoxication caused by interaction of chloramphenicol and phenytoin

1977 • 5 citations

Phenytoin Crystallization in Intravenous Fluids

1978 • 5 citations

Correlation of Serum Ethosuximide Levels with Clinical Effect

1975 • 4 citations

ELIMINATION OF BARBITURATES

1966 • 4 citations

PLASMA DIAZEPAM LEVELS AFTER SINGLE ORAL AND INTRAMUSCULAR ADMINISTRATION

1976 • 4 citations

Beitrag zum Stoffwechsel von Carbamazepin

1972 • 4 citations

The binding of phenobarbitone and phenytoin to kwashiorkor serum.

1977 • 4 citations

Clinical Pharmacokinetic Experiences with Clonazepam

1975 • 4 citations

Megaloblastic Anaemia developing during treatment of Epilepsy

1966 • 4 citations

[The metabolism of carbamazapine (author's transl)].

1972 • 4 citations

Serum protein binding of diphenylhydantoin in man. I. Interaction with sodium valproate.

1978 • 3 citations

SERUM-PHENYTOIN AND BODY-WEIGHT

1976 • 3 citations

[Serum phenobarbital levels in epileptics].

1975 • 3 citations

Sodium 2 n propyl pentanoate (2 PP) plasma concentrations in epileptic patients

1977 • 3 citations

Fluctuations of Serum Phenobarbital and Phenytoin Concentrations during Two Acute Episodes of Diabetic Ketoacidosis

1976 • 1 citations

[Ethnic differences in serum phenytoin levels].

1974 • 1 citations